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DK419

Catalog No. T15137 CAS 2102672-22-8

DK419 is an orally active inhibitor of Wnt/β-catenin signaling, with an IC50 of 0.19 μM. DK419 decreases protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin.It also induces production of pAMPK.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

DK419, CAS 2102672-22-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 135.00
5 mg	In stock	$ 289.00
10 mg	In stock	$ 455.00
25 mg	In stock	$ 753.00
50 mg	In stock	$ 1,060.00
100 mg	In stock	$ 1,430.00
1 mL * 10 mM (in DMSO)	In stock	$ 318.00

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Purity: 98.15%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	DK419 is an orally active inhibitor of Wnt/β-catenin signaling, with an IC50 of 0.19 μM. DK419 decreases protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin.It also induces production of pAMPK.
In vitro	DK419 inhibited the growth of CRC tumor cells in vitro and had good plasma exposure when dosed orally[1].
In vivo	DK419 inhibited the growth of patient derived CRC240 tumor explants in mice dosed orally[1].

Molecular Weight	407.7
Formula	C16H8ClF6N3O
CAS No.	2102672-22-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 80 mg/mL (196.22 mM), Sonification is recommended.

References and Literature

1. Wang J, et al. Identification of DK419, a potent inhibitor of Wnt/β-catenin signaling and colorectal cancer growth. Bioorg Med Chem. 2018 Nov 1;26(20):5435-5442.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Orally Active Compound Library Anti-Ovarian Cancer Compound Library Epigenetics Compound Library Anti-Cancer Compound Library Kinase Inhibitor Library Bioactive Compounds Library Max Anti-Cancer Metabolism Compound Library Metabolism Compound Library Anti-Metabolism Disease Compound Library

Related Products

Related compounds with same targets

TNIK-IN-5 β-catenin modulator IIa-661 9-Hydroxycanthin-6-one IWR-1 iCRT-5 JW74 Carboxylesterase-IN-2 Pyrvinium pamoate

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

DK419 2102672-22-8 Chromatin/Epigenetic Cytoskeletal Signaling PI3K/Akt/mTOR signaling Stem Cells Wnt/beta-catenin AMPK inhibit Wnt β-catenin DK-419 Inhibitor Beta catenin DK 419 inhibitor

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