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Trachelogenin

Catalog No. TN6508 CAS 34209-69-3

Synonyms: (-)-Trachelogenin

Trachelogenin ((-)-Trachelogenin), isolated from Combretum fruticosum, is an HCV entry inhibitor with anti-proliferative effects. Its mechanism is related to affecting the phosphorylation of key proteins such as β-Catenin, c-Myc and GSK3 in the β-Catenin signaling pathway. chemical and concentration-dependent. Trachelogenin has antiviral, anti-inflammatory and analgesic activities with IC50 of 0.325 and 0.259 μg/mL in HCVcc and HCVpp models, respectively.

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Trachelogenin, CAS 34209-69-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 178.00
5 mg	In stock	$ 440.00
10 mg	In stock	$ 648.00
25 mg	In stock	$ 987.00
50 mg	In stock	$ 1,390.00
1 mL * 10 mM (in DMSO)	In stock	$ 460.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Trachelogenin ((-)-Trachelogenin), isolated from Combretum fruticosum, is an HCV entry inhibitor with anti-proliferative effects. Its mechanism is related to affecting the phosphorylation of key proteins such as β-Catenin, c-Myc and GSK3 in the β-Catenin signaling pathway. chemical and concentration-dependent. Trachelogenin has antiviral, anti-inflammatory and analgesic activities with IC50 of 0.325 and 0.259 μg/mL in HCVcc and HCVpp models, respectively.
In vitro	Trachelogenin is an infection and HCVpp cell entry in a dose-dependent manner with an IC50 of 0.325 and 0.259 μg/mL in HCVcc and HCVpp models, respectively. Trachelogenin exhibits effective antiviral, anti-inflammatory, and analgesic effects.[1]
Source	Natural Products > Apocynaceae > Trachelospermum > Trachelospermum jasminoides (Lindl.) Lem

Synonyms	(-)-Trachelogenin
Molecular Weight	388.41
Formula	C21H24O7
CAS No.	34209-69-3

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 77.68 mg/mL (200 mM)

References and Literature

1. Qian XJ, et al. Trachelogenin, a novel inhibitor of hepatitis C virus entry through CD8J Gen Virol. 2016;97(5):1134-1144. 2. Koech PK, et al. Anti-glutamatergic Effects of Three Lignan Compounds: Arctigenin, Matairesinol and Trachelogenin - An ex vivo Study on Rat Brain Slices. Planta Med. 2023;89(9):879-889. 3. Mervai Z, et al. Endogenous enzyme-hydrolyzed fruit of Cirsium brachycephalum: optimal source of the antiproliferative lignan trachelogenin regulating the Wnt/β-catenin signaling pathway in the SW480 colon adenocarcinoma cell line. Fitoterapia. 2015;100:19-26.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Viral Compound Library

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Keywords

Trachelogenin 34209-69-3 Cell Cycle/Checkpoint Cytoskeletal Signaling Microbiology/Virology Proteases/Proteasome Stem Cells Wnt/beta-catenin Virus Protease c-Myc HCV Protease (-)-Trachelogenin inhibitor inhibit

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