Search Result

Search Results for " hif 1 "

Targets

Compounds

Natural Products

1737

Recombinant Proteins

Libraries

Cat No.	Product Name	Synonyms	Targets
T15482	HIF-2α-IN-1		HIF
	HIF-2α-IN-1 is a potent HIF-2α inhibitor with IC50 values less than 500 nM.		HIF
T67767	HIF-1 inhibitor-4	HIF-1 inhibitor-4	HIF
	HIF-1 inhibitor-4 (HIF-1 inhibitor-4) is a HIF-1 inhibitor with IC50 of 560 nM. HIF-1 inhibitor-4 reduces the HIF-1α protein level without affecting its mRNA level.		HIF
T36290	HIF-1 inhibitor-1
	HIF-1 inhibitor-1 is an aryl carboxamide compound and a potent hypoxia-inducible factor 1 (HIF-1) inhibitor with an IC50 of 0.32 μM for the cancer metastasi[1]. [1]. Liu M, et al. Discovery of Novel Aryl Carboxamide Deri...
T39040	HIF-PHD-IN-1
	HIF-PHD-IN-1 is a pharmacological compound that acts as an orally active inhibitor of the hypoxia-inducible factor prolyl hydroxylase domain (HIF-PHD), displaying an IC50 of 54 nM for hHIF-PHD2. Its potential as a therap...
TP1533	HIF-1 alpha (556-574)	HIF-1 alpha 556-574
	HIF-1 alpha (556-574) is a hypoxia-inducible factor-1 19-mer fragment. HIF-1 functions as master regulator of response to oxygen homeostasis. Hypoxia-induced gene expression is initiated when HIF-1subunit is stabilized i...
T9627	PHD-1-IN-1		HIF/HIF Prolyl-Hydroxylase
	PHD-1-IN-1 is a potent inhibitor of hypoxia-inducible factor prolylhydroxylase domain-1 (PHD-1) enzyme(IC50 = 0.034 μM).		HIF/HIF Prolyl-Hydroxylase
T29797	AKB-6899	AKB6899	VEGFR , HIF/HIF Prolyl-Hydroxylase , HIF
	AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macrophages. AKB-6899 leads to stabilization of HIF-2α which in...		VEGFR , HIF/HIF Prolyl-Hydroxylase , HIF
TP1546	HIF-1 alpha (556-574) TFA (1201633-99-9 free base)	HIF-1 alpha (556-574) TFA
	This is a hypoxia-inducible factor-1 (HIF-1 a) 19-mer fragment. HIF-1 functions as master regulator of response to oxygen homeostasis. Hypoxia-induced gene expression is initiated when HIF-1 subunit is stabilized in resp...
T6823	E3330		HIF/HIF Prolyl-Hydroxylase , DNA/RNA Synthesis
	E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.		HIF/HIF Prolyl-Hydroxylase , DNA/RNA Synthesis
T60413	HIF-IN-1		HIF
	HIF-IN-1 is a potent inhibitor of hypoxia-inducible factor (HIF-1), which is associated with tumor and cancer cell proliferation and inhibits HIF-1α protein aggregation.		HIF
T74804	HIF-1 inhibitor-5
	HIF-1 inhibitor-5 (Compound 16e) is a potent inhibitor of HIF-1, exhibiting an IC50 value of 2.38 μM and demonstrating significant anti-angiogenic potential [1].
T71659	Indacaterol acetate
	Indacaterol acetate is an ultra-long-acting beta-adrenoceptor agonist.
T71661	HIF-1α inhibitor-1
	HIF-1α inhibitor-1 is a HIF-1 alpha inhibitor.
T61442	HIF-1/2α-IN-1
	HIF-1/2α-IN-1, an orally active compound, functions as an inhibitor of HIF-2α. Its inhibitory effect on HIF-2α activity is significant, with an IC 50 value of 0.92 μM. Furthermore, HIF-1/2α-IN-1 has the ability to decrea...
T61102	HIF-1/2α-IN-2
	HIF-1/2α-IN-2 is a potent inhibitor of HIF-1/2α, which effectively reduces the levels of HIF-1/2α. This compound elicits an iron starvation response by specifically targeting ISCA2, a key protein involved in Iron Sulfur ...
T82199	HIF-1 alpha (556-574) (TFA)		HIF/HIF Prolyl-Hydroxylase
	HIF-1 alpha (556-574) TFA is a 19-residue fragment of hypoxia-inducible factor-1 (HIF-1), which serves as the master regulator of oxygen homeostasis [1].		HIF/HIF Prolyl-Hydroxylase
T3494	LW6	HIF-1α inhibitor,CAY10585,LW8	Apoptosis , Dehydrogenase , HIF/HIF Prolyl-Hydroxylase , HIF
	LW6 (HIF-1α inhibitor) is a novel HIF-1 inhibitor.
T15396	GN44028	N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine	HIF
	GN44028 (N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine) is a hypoxia-inducible factor inhibitor of (HIF)-1 (IC50: 14 nM). GN44028 inhibits hypoxia-induced HIF-1α transcriptional activity. H...		HIF
T75098	HIF-PHD-IN-3		Reactive Oxygen Species
	HIF-PHD-IN-3 is a potent hiPSC-CM cardioprotective scaffold with potential inhibitory effects on HIF-PHD, regulates heme oxygenase-1, and can be used to study anaemia.		Reactive Oxygen Species
T5537	IDF-11774		HIF/HIF Prolyl-Hydroxylase , HIF
	IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM).		HIF/HIF Prolyl-Hydroxylase , HIF
T7836	ML228		HIF
	ML228 is a potent the Hypoxia Inducible Factor (HIF) pathway activator with EC50 of 1 μM. ML228 potently activates HIF in vitro as well as its downstream target VEGF.		HIF
T13050	SYP-5		HIF/HIF Prolyl-Hydroxylase , HIF
	SYP-5 is a novel inhibitor of HIF-1, suppresses tumor cells invasion and angiogenesis.		HIF/HIF Prolyl-Hydroxylase , HIF
T22022	Adaptaquin		HIF
	Adaptaquin is an inhibitor of the hypoxia-inducing factor prolyl hydroxylase (HIF-PH) [1] [2].		HIF
T3169	KC7F2		HIF/HIF Prolyl-Hydroxylase , HIF
	KC7F2 is a potent HIF-1 pathway inhibitor with potential anti-cancer activity.		HIF/HIF Prolyl-Hydroxylase , HIF
T2488	BAY 87-2243		Ferroptosis , HIF/HIF Prolyl-Hydroxylase , HIF
	BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).		Ferroptosis , HIF/HIF Prolyl-Hydroxylase , HIF
T9890	HIF1-IN-3	Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]-	HIF
	HIF1-IN-3 (Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]-) is an effective inhibitor of HIF-1 (EC50 = 0.9 μM) and can be used in anticancer studies.		HIF
T4106	MK-8617	MK8617	HIF/HIF Prolyl-Hydroxylase
	MK-8617 is an orally available HIF PHD1 3 pan-inhibitor, inhibiting PHD1/2/3 (IC50: 1.0/1.0/14 nM).		HIF/HIF Prolyl-Hydroxylase
T36953	Naphthofluorescein	Naphthafluorescein	HIF
	Naphthofluorescein （Naphthafluorescein） is a Mint3 inhibitor with potential antitumor and anti-inflammatory activities, inhibits the interaction between HIF-1 and Mint3, inhibits Mint3-dependent HIF-1 activity, and inhib...		HIF
T8973	HS-1793		Others
	HS-1793, a resveratrol analogue, downregulates the expression of hypoxia-induced HIF-1 and VEGF and inhibits tumor growth of human breast cancer cells in a nude mouse xenograft model		Others
T4381	Lificiguat	YC-1	Others , Guanylate cyclase , HIF
	Lificiguat (YC-1) is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase(sGC) and an inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha).		Others , Guanylate cyclase , HIF
T1823	IOX2	IOX 2,JICL38	HIF/HIF Prolyl-Hydroxylase
	IOX2 (IOX 2) is a selective inhibitor of the Hypoxia Inducible Factor (HIF) Prolyl-Hydroxylases (PHD); active in cells with the IC50 value of 21 nM for PHD2/ELGN-1 and no inhibition at FIH (20uM).		HIF/HIF Prolyl-Hydroxylase
T2283	PX-12	IV-2,PX12	Thioredoxin
	PX-12 (PX12) (1-methylpropyl 2-imidazolyl disulfide) is a small-molecule inhibitor of Trx-1 (thioredoxin-1), stimulates apoptosis, down-regulates HIF-1α and vascular endothelial growth factor (VEGF) and inhibits tumor gr...		Thioredoxin
T0153	Oltipraz	NSC 347901,RP 35972	HIF/HIF Prolyl-Hydroxylase , HIV Protease , Reverse Transcriptase , Nrf2 , HIF
	Oltipraz (RP 35972) is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes, such as glutathione S transferase (GST) and NAD(P)H: quin...
T6804	Chetomin	Chaetomin,NSC289491,BRN0077366	Apoptosis , HSP , HIF
	Chetomin (BRN0077366) is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar concentrations.		Apoptosis , HSP , HIF
T61367	HIF-2α-IN-6
	HIF-2α-IN-6 (117) is a HIF-2α inhibitor [1].
TP2046	TAT-cyclo-CLLFVY
	Selective HIF-1 dimerization inhibitor. Blocks protein-protein interaction of recombinant HIF-1α, but not HIF-2α, with HIF-1β (IC50 = 1.3 μM). Inhibits hypoxia-induced HIF-1 activity, and decreases VEGF and CAIX expressi...
T27866	LXY6090	LXY 6090,LXY-6090
	LXY6090 is a HIF-1 inhibitor. LXY6090 inhibited the activity of HIF-1 and downregulated the protein level of HIF-1α in breast cancer cells. LXY6090 showed in vivo anticancer efficacy by decreasing the HIF-1α expression i...
T61161	HIF-1α-IN-3
	HIF-1α-IN-3, also known as Compound (S)-3f, is a hypoxia-selective inhibitor of HIF-1α. It exhibits potent antiestrogenic activity [1].
T75943	TAT-cyclo-CLLFVY TFA
	TAT-cyclo-CLLFVY TFA is a cyclic peptide inhibitor specifically targeting HIF-1 heterodimerization to mitigate hypoxia signaling within cancer cells. It effectively disrupts the protein-protein interaction between HIF-1α...
T23894	CLB-016
	CLB-016 is an inhibitor of hypoxia-inducible factor (HIF)-1.
T82198	HIF-1α-IN-6		HIF/HIF Prolyl-Hydroxylase
	HIF-1α-IN-6 (compound 3s) is a potent inhibitor of HIF-1α, demonstrating IC50 values of 0.6 nM and 53.3 nM in MiaPaCa-2 and MDA-MB-231 cells, respectively. It suppresses HIF-1α expression through the reduction of HIF-1α ...		HIF/HIF Prolyl-Hydroxylase
T61614	HIF-2α-IN-5
	HIF-2α-IN-5 is a potent HIF-2α inhibitor with an IC 50 of < 50 nM [1].
T60524	HIF-1α-IN-4
	HIF-1α-IN-4 is an inhibitor of HIF-1α with IC50 of 24 nM in HEK293T cells which has potential antitumor effects. HIF-1α-IN-4 downregulates VEGF and PDK1 mRNA expressions under hypoxia [1].
T64310	KUSC-5001
	KUSC-5001 is a potent inhibitor (IC50: 18 μM) of HIF-1, which has a key role in tumour survival and malignancy.
T12547	Prolyl Hydroxylase inhibitor 1		Others
	Prolyl Hydroxylase inhibitor 1 is an orally active inhibitor of hypoxia inducible factor (HIF)-prolyl hydroxylase (PHD) (IC50 of 62.23 nM).		Others
T60398	Dimethyl-bisphenol A
	Dimethyl-bisphenol A (DMBPA) is the potent inhibitor of HIF-1α. Dimethyl-Bisphenol A promotes degradation of HIF-1α protein by dissociating Hsp90 from HIF-1α. Dimethyl-bisphenol A can decrease the expression of Vegfa mRN...
T60532	HIF-1α-IN-5
	HIF-1α-IN-5 is an inhibitor of HIF-1α with an IC 50 value of 24 nM in HEK293T cells that also inhibits the activity of MAO-A. HIF-1α-IN-5 downregulates the mRNA expressions of VEGF and PDK1 under hypoxia. HIF-1α-IN-5 has...
T78123	HIF-1α-IN-2 hydrochloride		HIF/HIF Prolyl-Hydroxylase
	HIF-1α-IN-2 hydrochloride is a potent HIF-1α inhibitor exhibiting anticancer activity, demonstrated by IC50 values of 28 nM in MDA-MB-231 cells and 15 nM in MiaPaCa-2 cells. It effectively suppresses HIF-1α expression by...		HIF/HIF Prolyl-Hydroxylase
T82595	DEALA-Hyp-YIPD
	DEALA-Hyp-YIPD, an HIF-1α peptide inhibitor, impedes the VHL/HIF-1α interaction with an half-maximal inhibitory concentration (IC50) of 0.91 μM and a dissociation constant (Kd) of 180 nM [1].
T74027	1-Palmitoyl-2-oleoyl-sn-glycerol
	1-Palmitoyl-2-oleoyl-sn-glycerol, an endogenous metabolite, serves as a predominant diacylglycerol in the hormogonium-inducing factor (HIF)-1 [1].

Compounds

Synonym: HIF-1 inhibitor-4

HIF-1 alpha (556-574)

TP1533

Synonym: HIF-1 alpha 556-574

Target: HIF/HIF Prolyl-Hydroxylase

AKB-6899

T29797

Synonym: AKB6899

Target: VEGFR, HIF/HIF Prolyl-Hydroxylase, HIF

HIF-1 alpha (556-574) TFA (1201633-99-9 free base)

TP1546

Synonym: HIF-1 alpha (556-574) TFA

Target: HIF/HIF Prolyl-Hydroxylase, DNA/RNA Synthesis

HIF-1 alpha (556-574) (TFA)

T82199

Synonym:

Target: HIF/HIF Prolyl-Hydroxylase

LW6

T3494

Synonym: HIF-1α inhibitor,CAY10585,LW8

Target: Apoptosis, Dehydrogenase, HIF/HIF Prolyl-Hydroxylase, HIF

GN44028

T15396

Synonym: N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine

Target: Reactive Oxygen Species

IDF-11774

T5537

Synonym:

Target: HIF/HIF Prolyl-Hydroxylase, HIF

Target: HIF/HIF Prolyl-Hydroxylase, HIF

Target: HIF/HIF Prolyl-Hydroxylase, HIF

BAY 87-2243

T2488

Synonym:

Target: Ferroptosis, HIF/HIF Prolyl-Hydroxylase, HIF

HIF1-IN-3

T9890

Synonym: Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]-

Target: HIF/HIF Prolyl-Hydroxylase

Naphthofluorescein

T36953

Synonym: Naphthafluorescein

Target: Others, Guanylate cyclase, HIF

IOX2

T1823

Synonym: IOX 2,JICL38

Target: HIF/HIF Prolyl-Hydroxylase

Synonym: NSC 347901,RP 35972

Target: HIF/HIF Prolyl-Hydroxylase, HIV Protease, Reverse Transcriptase, Nrf2, HIF

Chetomin

T6804

Synonym: Chaetomin,NSC289491,BRN0077366

Target: Apoptosis, HSP, HIF

Synonym: LXY 6090,LXY-6090

Target: HIF/HIF Prolyl-Hydroxylase

Prolyl Hydroxylase inhibitor 1

HIF-1α-IN-2 hydrochloride

T78123

Synonym:

Target: HIF/HIF Prolyl-Hydroxylase

1-Palmitoyl-2-oleoyl-sn-glycerol

T74027

Synonym:

Target:

Cat No.	Product Name	Synonyms	Targets
T1205	Chloramphenicol	Chlornitromycin,Levomycetin,Chloromycetin	ribosome , HIF/HIF Prolyl-Hydroxylase , Antibacterial , Antibiotic
	Chloramphenicol (Chloromycetin), a broad-spectrum antibiotic, blocks bacterial protein synthesis.
T10233	Acetylarenobufagin		HIF
	Acetylarenobufagin is a steroidal hypoxia-inducible factor-1 (HIF-1) modulator.		HIF
T3404	Cucurbitacin B	Cuc B,DATISCACIN,Amarine	Apoptosis , PTEN , Integrin , Endogenous Metabolite , HIF , STAT , Autophagy
	Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation through up-regulation of PTEN. Cucurbitacin B is an effective inh...
T5429	Theaflavin 3,3'-digallate	8-Gingerol,TFDG	Virus Protease , Antioxidant , HIV Protease , HSV
	Theaflavin 3,3'-digallate (8-Gingerol) , a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancer chemopreventive actions, it reduces tumor angiogenesis by downregul...		Virus Protease , Antioxidant , HIV Protease , HSV
T6429	Caffeic Acid Phenethyl Ester	Phenylethyl Caffeate,CAPE	Apoptosis , NF-κB
	Caffeic Acid Phenethyl Ester (Phenylethyl Caffeate) (CAPE) inhibits the activation of nuclear transcription factor NF-kappa B and may suppress p70S6K and Akt-driven signaling pathways, with antineoplastic, cytoprotective...		Apoptosis , NF-κB
T4S1551	Cinnamaldehyde	Cinnamic Aldehyde	HIF
	1. Cinnamaldehyde (Cinnamic Aldehyde) has antipyretic activity. 2. Cinnamaldehyde is a sedative agent. 3. Cinnamaldehyde inhibits invasive capabilities of MDA-MB-435S cells was correlated with down-regulating the express...		HIF
T6S0071	Fraxinellone		HIF/HIF Prolyl-Hydroxylase , STAT , PD-1/PD-L1
	1. Fraxinellone significantly reduced weight loss and diarrhea in mice and alleviated the macroscopic and microscopic signs of the disease. 2. Fraxinellone exhibited a variety of insecticidal activities including feeding...		HIF/HIF Prolyl-Hydroxylase , STAT , PD-1/PD-L1
T3S2344	β,β-Dimethylacrylshikonin	Dimethylacrylshikonin,β, β-Dimethylacrylshikonin	ERK , HIF/HIF Prolyl-Hydroxylase
	1. β,β-Dimethylacrylshikonin (Dimethylacrylshikonin) is a promising agent for developing an improved strategy for radiotherapy against tumors. (a) Injection of Dimethylacrylshikonin combined with IR treatment significant...		ERK , HIF/HIF Prolyl-Hydroxylase
T75487	7-Hydroxyneolamellarin A
	7-Hydroxyneolamellarin A, a natural product from the sponge Dendrilla nigra, serves as a potent inhibitor of hypoxia-inducible factor-1α (HIF-1α). It effectively reduces the accumulation of HIF-1α protein and suppresses ...
TN1952	Moracin P		Others , ROS , HIF
	Moracin P exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1), which is a key mediator during adaptation of cancer cells to tumour hypoxia.		Others , ROS , HIF
T36749	Herboxidiene
	Herboxidiene is a polyketide originally isolated from S. chromofuscus that has diverse biological activities.[1],[2,][3],[4],[5] It inhibits growth of HeLa S3, SK-MEL-2, PC3, A549, and EBC-1 cells with GI50 values rangin...
T36439	Gramicidin A		Antibacterial , HIF , Parasite
	Gramicidin A is a peptide antibiotic isolated from B. brevis.Gramicidin A is a highly hydrophobic channel-forming ion carrier that forms monovalent cation-permeable channels in artificial membranes.Gramicidin A induces t...		Antibacterial , HIF , Parasite
TN4489	Manassantin A		ERK , cAMP , TNF , NF-κB , MAPK , COX , HIF , Prostaglandin Receptor , JNK , STAT
	Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effects might be associated with COX/PGE2 stimulation, inhibitio...
TN1951	Moracin O		HIF
	Moracin O shows significant neuroprotective, and analgesic activities, it also has a strong protective influence against doxorubicin-induced cardiomyopathy in H9c2 cells with the EC50 value of 4.5 ± 1.3 μM. Moracin O exh...		HIF

Natural Products

Chloramphenicol

T1205

Synonym: Chlornitromycin,Levomycetin,Chloromycetin

Target: ribosome, HIF/HIF Prolyl-Hydroxylase, Antibacterial, Antibiotic

Synonym: Cuc B,DATISCACIN,Amarine

Target: Apoptosis, PTEN, Integrin, Endogenous Metabolite, HIF, STAT, Autophagy

Theaflavin 3,3'-digallate

T5429

Synonym: 8-Gingerol,TFDG

Target: Virus Protease, Antioxidant, HIV Protease, HSV

Caffeic Acid Phenethyl Ester

T6429

Synonym: Phenylethyl Caffeate,CAPE

Target: Apoptosis, NF-κB

Cinnamaldehyde

T4S1551

Synonym: Cinnamic Aldehyde

Target: HIF/HIF Prolyl-Hydroxylase, STAT, PD-1/PD-L1

β,β-Dimethylacrylshikonin

T3S2344

Synonym: Dimethylacrylshikonin,β, β-Dimethylacrylshikonin

Target: ERK, HIF/HIF Prolyl-Hydroxylase

7-Hydroxyneolamellarin A

Target: Others, ROS, HIF

Target: Antibacterial, HIF, Parasite

Manassantin A

TN4489

Synonym:

Target: ERK, cAMP, TNF, NF-κB, MAPK, COX, HIF, Prostaglandin Receptor, JNK, STAT

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-01709	HIF-1 alpha Protein, Human, Recombinant (His)	Human	E. coli
	HIF-1 alpha, also known as HIF1A, contains 1 basic helix-loop-helix (bHLH) domain, 1 PAC (PAS-associated C-terminal) domain, and 2 PAS (PER-ARNT-SIM) domains. It is one of the two subunits of Hypoxia-inducible factor-1 (...
TMPH-01280	EGLN1 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of th...
TMPH-00957	ARNT Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	ARNT Protein, Human, Recombinant (His) is expressed in Yeast.
TMPY-04671	MCP-5 Protein, Mouse, Recombinant (His)	Mouse	P. pastoris (Yeast)
	Ccl12 prevented initiation of the reparative response by prolonging inflammation and inhibiting fibroblast conversion to myofibroblasts, resulting in diminished scar formation. Macrophage secretion of Ccl12 directly impa...
TMPH-01512	HIF1AN Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coa...
TMPY-02376	BNIP3L Protein, Human, Recombinant	Human	E. coli
	The deletion of BNIP3L results in retention of mitochondria during lens fiber cell remodeling, and that deletion of BNIP3L also results in the retention of endoplasmic reticulum and Golgi apparatus. BNIP3L localizes to t...
TMPY-04451	AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 160 kDa and the accession number is P54619-1&Q9Y478-1&...
TMPY-03745	CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His)	Human	HEK293 Cells
	CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with Flag and His tag. The predicted molecular weight is 31.05 kDa and the accession number is P04234-1&P07766-1.
TMPY-03878	Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His)	Human	HEK293 Cells
	Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with Flag and His tag. The predicted molecular weight is 190.4 kDa and the accession number is P06756-1&P18564-1.
TMPY-02501	CD3D & CD3E Heterodimer Protein, Human, Recombinant	Human	HEK293 Cells
	CD3D & CD3E Heterodimer Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 77.5 kDa and the accession number is P04234-1&P07766-1.
TMPY-02335	OSMR Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	OSMR Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 83.7 kDa and the accession number is O70458-1.
TMPY-02112	FGFR4 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	FGFR4 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40 kDa and the accession number is P22455-1.
TMPY-01920	BAFF/TNFSF13B Protein, Human, Recombinant (HEK293)	Human	HEK293 Cells
	BAFF/TNFSF13B Protein, Human, Recombinant (HEK293) is expressed in HEK293 mammalian cells. The predicted molecular weight is 17 kDa and the accession number is Q9Y275-1.
TMPY-02591	SDF-1 Protein, Human, Recombinant	Human	E. coli
	SDF-1 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 8.6 kDa and the accession number is P48061-1.
TMPY-01053	Prolactin Receptor Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Prolactin Receptor Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26 kDa and the accession number is P16471-1.
TMPY-01349	ICAM-1/CD54 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	ICAM-1/CD54 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 51.7 kDa and the accession number is P13597-1.
TMPY-00820	IgG1 Fc Protein, Human, Recombinant (C103S)	Human	HEK293 Cells
	IgG1 Fc Protein, Human, Recombinant (C103S) is expressed in HEK293 mammalian cells. The predicted molecular weight is 26 kDa and the accession number is P01857-1.
TMPY-00742	EGFR Protein, Human, Recombinant (His)	Human	HEK293 Cells
	EGFR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 69.8 kDa and the accession number is P00533-1.
TMPY-02603	STAT6 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that is activated by interleukin-4 (IL-4)-induced tyrosine phosphorylation and mediates most of the IL-4-induced gene expression. STAT6...
TMPY-01003	TCN2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	TCN2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46.7 kDa and the accession number is P20062-1.
TMPY-06873	FLT3 Ligand Protein, Human, Recombinant	Human	E. coli
	FLT3 Ligand Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.75 kDa and the accession number is P49771-1.
TMPY-01968	CD32A Protein, Human, Recombinant (167 His, His)	Human	HEK293 Cells
	CD32A Protein, Human, Recombinant (167 His, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 22 kDa and the accession number is P12318-1.
TMPY-01395	CTHRC1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	CTHRC1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24.5 kDa and the accession number is Q96CG8-1.
TMPY-01389	HER3/ERBB3 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	HER3/ERBB3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70.2 kDa and the accession number is P21860-1.
TMPY-01813	ACRV1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Acrosomal protein SP-1, also known as Acrosomal vesicle protein 1 and ACRV1, is a testis-specific, differentiation antigen, that arises within the acrosomal vesicle during spermatogenesis, and is associated with the a...
TMPY-02700	BCL2 Protein, Human, Recombinant (His)	Human	E. coli
	BCL2 (B-cell leukemia/lymphoma 2, N-Histidine-tagged), also known as Bcl-2, belongs to the Bcl-2 family. Bcl-2 family proteins regulate and contribute to programmed cell death or apoptosis. It is a large protein family a...
TMPY-05840	IL-1RAP/IL-1RAcP Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	IL-1RAP/IL-1RAcP Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40.56 kDa and the accession number is P59822-1.
TMPY-04104	LIF Protein, Human, Recombinant	Human	HEK293 Cells
	LIF Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 19.7 kDa and the accession number is P15018-1.
TMPY-04939	LAG-3 Protein, Human, Recombinant	Human	HEK293 Cells
	LAG-3 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 45.3 kDa and the accession number is P18627-1.
TMPY-00925	SOST Protein, Human, Recombinant (His)	Human	HEK293 Cells
	SOST Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 22.5 kDa and the accession number is Q9BQB4-1.
TMPY-02062	SULT1A1 Protein, Human, Recombinant (His)	Human	E. coli
	Sulfate conjugation catalyzed by cytosolic sulfotransferase (SULT) enzymes. The SULTs are Phase II drug-metabolizing enzymes that catalyze the addition of a sulfuryl moiety to both endogenous compounds, including steroid...
TMPY-03782	Albumin Protein, Human, Recombinant	Human	P. pastoris (Yeast)
	Albumin Protein, Human, Recombinant is expressed in yeast. The predicted molecular weight is 66.4 kDa and the accession number is P02768-1.
TMPY-00843	IL-25/IL17E Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	IL-25/IL17E Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45 kDa and the accession number is Q9H293-1.
TMPY-04153	RNF43 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	RNF43 mutations are frequently detected in colorectal cancer cells and lead to a loss of function of the ubiquitin E3 ligase. The outer mitochondrial membrane 34 (TOMM34) and ring finger protein 43 (RNF43) as highly expr...
TMPY-01209	IL-7R alpha/CD127 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	IL-7R alpha/CD127 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.3 kDa and the accession number is P16871-1.
TMPY-05566	Siglec-2/CD22 Protein, Human, Recombinant (His, Solution)	Human	HEK293 Cells
	Siglec-2/CD22 Protein, Human, Recombinant (His, Solution) is expressed in HEK293 mammalian cells with His tag. The accession number is P20273-1.
TMPY-01137	HER2/ERBB2 Protein, Human, Recombinant (aa 1-652, His)	Human	HEK293 Cells
	HER2/ERBB2 Protein, Human, Recombinant (aa 1-652, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71 kDa and the accession number is P04626-1.
TMPY-05593	IL-1RAP/IL-1RAcP Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	IL-1RAP/IL-1RAcP Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 42.4 kDa and the accession number is Q9NPH3-1.
TMPY-00835	IGFBP-3 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	IGFBP-3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31 kDa and the accession number is P17936-1.
TMPY-04824	CTLA-4 Protein, Human, Recombinant	Human	HEK293 Cells
	CTLA-4 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 13.5 kDa and the accession number is P16410-1.
TMPY-01062	EGF Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	EGF Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 33 kDa and the accession number is P01133-1.
TMPY-00686	Complement C2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Complement C2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 82.5 kDa and the accession number is P06681-1.
TMPY-01934	IL-21R Protein, Human, Recombinant (His)	Human	HEK293 Cells
	IL-21R Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.5 kDa and the accession number is Q9HBE5-1.
TMPY-01145	NKp30/NCR3 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	NKp30/NCR3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.4 kDa and the accession number is O14931-1.
TMPY-00694	Carbonic Anhydrase 12 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Carbonic Anhydrase 12 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31.6 kDa and the accession number is O43570-1.
TMPY-02141	UPAR/PLAUR Protein, Human, Recombinant (His)	Human	HEK293 Cells
	uPAR/PLAUR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32.8 kDa and the accession number is Q03405-1.
TMPY-01076	Gp130/IL6ST Protein, Human, Recombinant (His & hFc)	Human	HEK293 Cells
	gp130/IL6ST Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 96 kDa and the accession number is P40189-1.
TMPY-01139	PDGFRA Protein, Human, Recombinant (His)	Human	HEK293 Cells
	PDGFRA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.7 kDa and the accession number is P16234-1.
TMPY-02312	CSF3R/G-CSFR Protein, Human, Recombinant (His)	Human	HEK293 Cells
	CSF3R/G-CSFR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 68 kDa and the accession number is Q99062-1.
TMPY-03215	FLT3 Ligand Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	FLT3 Ligand Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 20.2 kDa and the accession number is P49771-1.
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HIF-1 alpha Protein, Human, Recombinant (His)

TMPY-01709

Species: Human

Expression System: E. coli

EGLN1 Protein, Human, Recombinant (His & Myc)

TMPH-01280

Species: Human

Expression System: E. coli

ARNT Protein, Human, Recombinant (His)

TMPH-00957

Species: Human

Expression System: P. pastoris (Yeast)

MCP-5 Protein, Mouse, Recombinant (His)

TMPY-04671

Species: Mouse

Expression System: P. pastoris (Yeast)

HIF1AN Protein, Human, Recombinant (His)

TMPH-01512

Species: Human

Expression System: P. pastoris (Yeast)

BNIP3L Protein, Human, Recombinant

TMPY-02376

Species: Human

Expression System: E. coli

AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST)

TMPY-04451

Species: Human

Expression System: Baculovirus Insect Cells

CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His)

TMPY-03745

Species: Human

Expression System: HEK293 Cells

Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His)

TMPY-03878

Species: Human

Expression System: HEK293 Cells

CD3D & CD3E Heterodimer Protein, Human, Recombinant

TMPY-02501

Species: Human

Expression System: HEK293 Cells

OSMR Protein, Mouse, Recombinant (His)

TMPY-02335

Species: Mouse

Expression System: HEK293 Cells

FGFR4 Protein, Human, Recombinant (His)

TMPY-02112

Species: Human

Expression System: HEK293 Cells

BAFF/TNFSF13B Protein, Human, Recombinant (HEK293)

TMPY-01920

Species: Human

Expression System: HEK293 Cells

SDF-1 Protein, Human, Recombinant

TMPY-02591

Species: Human

Expression System: E. coli

Prolactin Receptor Protein, Human, Recombinant (His)

TMPY-01053

Species: Human

Expression System: HEK293 Cells

ICAM-1/CD54 Protein, Mouse, Recombinant (His)

TMPY-01349

Species: Mouse

Expression System: HEK293 Cells

IgG1 Fc Protein, Human, Recombinant (C103S)

TMPY-00820

Species: Human

Expression System: HEK293 Cells

EGFR Protein, Human, Recombinant (His)

TMPY-00742

Species: Human

Expression System: HEK293 Cells

STAT6 Protein, Human, Recombinant (His)

TMPY-02603

Species: Human

Expression System: Baculovirus Insect Cells

TCN2 Protein, Human, Recombinant (His)

TMPY-01003

Species: Human

Expression System: HEK293 Cells

FLT3 Ligand Protein, Human, Recombinant

TMPY-06873

Species: Human

Expression System: E. coli

CD32A Protein, Human, Recombinant (167 His, His)

TMPY-01968

Species: Human

Expression System: HEK293 Cells

CTHRC1 Protein, Human, Recombinant (His)

TMPY-01395

Species: Human

Expression System: HEK293 Cells

HER3/ERBB3 Protein, Human, Recombinant (His)

TMPY-01389

Species: Human

Expression System: HEK293 Cells

ACRV1 Protein, Human, Recombinant (His)

TMPY-01813

Species: Human

Expression System: HEK293 Cells

BCL2 Protein, Human, Recombinant (His)

TMPY-02700

Species: Human

Expression System: E. coli

IL-1RAP/IL-1RAcP Protein, Cynomolgus, Recombinant (His)

TMPY-05840

Species: Cynomolgus

Expression System: HEK293 Cells

LIF Protein, Human, Recombinant

TMPY-04104

Species: Human

Expression System: HEK293 Cells

LAG-3 Protein, Human, Recombinant

TMPY-04939

Species: Human

Expression System: HEK293 Cells

SOST Protein, Human, Recombinant (His)

TMPY-00925

Species: Human

Expression System: HEK293 Cells

SULT1A1 Protein, Human, Recombinant (His)

TMPY-02062

Species: Human

Expression System: E. coli

Albumin Protein, Human, Recombinant

TMPY-03782

Species: Human

Expression System: P. pastoris (Yeast)

IL-25/IL17E Protein, Human, Recombinant (hFc)

TMPY-00843

Species: Human

Expression System: HEK293 Cells

RNF43 Protein, Human, Recombinant (His)

TMPY-04153

Species: Human

Expression System: HEK293 Cells

IL-7R alpha/CD127 Protein, Human, Recombinant (His)

TMPY-01209

Species: Human

Expression System: HEK293 Cells

Siglec-2/CD22 Protein, Human, Recombinant (His, Solution)

TMPY-05566

Species: Human

Expression System: HEK293 Cells

HER2/ERBB2 Protein, Human, Recombinant (aa 1-652, His)

TMPY-01137

Species: Human

Expression System: HEK293 Cells

IL-1RAP/IL-1RAcP Protein, Human, Recombinant (His & Avi), Biotinylated

TMPY-05593

Species: Human

Expression System: HEK293 Cells

IGFBP-3 Protein, Human, Recombinant (His)

TMPY-00835

Species: Human

Expression System: HEK293 Cells

CTLA-4 Protein, Human, Recombinant

TMPY-04824

Species: Human

Expression System: HEK293 Cells

EGF Protein, Human, Recombinant (hFc)

TMPY-01062

Species: Human

Expression System: HEK293 Cells

Complement C2 Protein, Human, Recombinant (His)

TMPY-00686

Species: Human

Expression System: HEK293 Cells

IL-21R Protein, Human, Recombinant (His)

TMPY-01934

Species: Human

Expression System: HEK293 Cells

NKp30/NCR3 Protein, Human, Recombinant (His)

TMPY-01145

Species: Human

Expression System: HEK293 Cells

Carbonic Anhydrase 12 Protein, Human, Recombinant (His)

TMPY-00694

Species: Human

Expression System: HEK293 Cells

uPAR/PLAUR Protein, Human, Recombinant (His)

TMPY-02141

Species: Human

Expression System: HEK293 Cells

gp130/IL6ST Protein, Human, Recombinant (His & hFc)

TMPY-01076

Species: Human

Expression System: HEK293 Cells

PDGFRA Protein, Human, Recombinant (His)

TMPY-01139

Species: Human

Expression System: HEK293 Cells

CSF3R/G-CSFR Protein, Human, Recombinant (His)

TMPY-02312

Species: Human

Expression System: HEK293 Cells

FLT3 Ligand Protein, Human, Recombinant (His)

TMPY-03215

Species: Human

Expression System: Baculovirus Insect Cells

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Cat No.	Product Name
L8500	HIF-1 Signaling Pathway Compound Library	1336 compounds
	A unique collection of 1336 HIF-1 related small chemicals can be used for drug discovery in ischemic disease and cancer and related mechanism studies；
L2130	Anti-Cancer Metabolism Compound Library	1268 compounds
	A unique collection of 1268 cancer cellular metabolism related compounds for cancer research and high throughput screening (HTS) and high content screening (HCS);

Libraries

HIF-1 Signaling Pathway Compound Library

L8500

Compounds: 1336

Anti-Cancer Metabolism Compound Library

L2130

Compounds: 1268