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GPCR/G Protein CAMP Manassantin A

Manassantin A

Catalog No. TN4489   CAS 88497-87-4

Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effects might be associated with COX/PGE2 stimulation, inhibition of iNOS production and NF-κB activation, and improvements in the antioxidant and anti-inflammatory status.Manassantin A represents a potential therapeutic approach for the treatment of airway allergic-inflammatory diseases. Manassantin A inhibits cAMP-induced melanin production by down-regulating the gene expressions of MITF and tyrosinase in melanocytes.

Manassantin A, CAS 88497-87-4
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effects might be associated with COX/PGE2 stimulation, inhibition of iNOS production and NF-κB activation, and improvements in the antioxidant and anti-inflammatory status.Manassantin A represents a potential therapeutic approach for the treatment of airway allergic-inflammatory diseases. Manassantin A inhibits cAMP-induced melanin production by down-regulating the gene expressions of MITF and tyrosinase in melanocytes.
Targets&IC50 cAMP ,   COX ,   ERK ,   HIF ,   JNK ,   LTC ,   MAPK ,   MITF ,   NF-κB ,   p65 ,   PGE ,   PLA ,   STAT ,   TNF-α ,   TRP1
Molecular Weight 732.9
Formula C42H52O11
CAS No. 88497-87-4

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Hepatoprotective constituents of Saururus chinensis roots against tacrine-induced cytotoxicity in human liver-derived Hep G2 cells. Korean Journal of Pharmacognosy, 2007, 38(2):176-180. 2. Manassantin A inhibits cAMP-induced melanin production by down-regulating the gene expressions of MITF and tyrosinase in melanocytes. Experimental dermatology, 2011, 20(9):761-763.

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