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AKB-6899

Catalog No. T29797 CAS 1007377-55-0

Synonyms: AKB6899

AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macrophages. AKB-6899 leads to stabilization of HIF-2α which induces sVEGFR-1 production from tumor-associated macrophages and decreases tumor growth.

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AKB-6899, CAS 1007377-55-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 74.00
5 mg	In stock	$ 178.00
10 mg	In stock	$ 288.00
25 mg	In stock	$ 485.00
50 mg	In stock	$ 693.00
100 mg	In stock	$ 987.00
1 mL * 10 mM (in DMSO)	In stock	$ 197.00

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Purity: 97.11%

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Description	AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macrophages. AKB-6899 leads to stabilization of HIF-2α which induces sVEGFR-1 production from tumor-associated macrophages and decreases tumor growth.
In vitro	In murine bone marrow-derived macrophages, AKB-6899 (10 μM; 24 hours) increases the levels of HIF-2α protein, with no corresponding increase in HIF-1α. AKB-6899 shows no effect on HIF-1α accumulation or VEGF production[1].
In vivo	In C57BL/6 mice injected with B16F10 murine melanoma cells, AKB-6899 (17.5 mg/kg; i.p.) significantly reduces tumor growth[1].

Synonyms	AKB6899
Molecular Weight	290.25
Formula	C14H11FN2O4
CAS No.	1007377-55-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 95 mg/mL (327.30 mM), Sonification is recommended.

References and Literature

1. Roda JM, Wang Y, Sumner LA, Phillips GS, Marsh CB, Eubank TD. Stabilization of HIF-2α induces sVEGFR-1 production from tumor-associated macrophages and decreases tumor growth in a murine melanoma model. J Immunol. 2012 Sep 15;189(6):3168-77. doi: 10.4049/jimmunol.1103817. Epub 2012 Aug 6. PubMed PMID: 22869907; PubMed Central PMCID: PMC3436995.

Related compound libraries

This product is contained In the following compound libraries：

Tyrosine Kinase Inhibitor Library Kinase Inhibitor Library Inhibitor Library Anti-Breast Cancer Compound Library Anti-Pancreatic Cancer Compound Library Anti-Cancer Metabolism Compound Library Anti-Ovarian Cancer Compound Library Metabolism Compound Library Anti-Cancer Compound Library Anti-Cardiovascular Disease Compound Library

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Keywords

AKB-6899 1007377-55-0 Angiogenesis Chromatin/Epigenetic Metabolism Tyrosine Kinase/Adaptors HIF VEGFR HIF/HIF Prolyl-Hydroxylase antiangiogenic Inhibitor antitumor AKB 6899 HIF-PH HIF-2α sVEGFR-1 HIFs AKB6899 inhibit Hypoxia-inducible factors PHD3 inhibitor

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