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E3330

Catalog No. T6823   CAS 136164-66-4

E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.

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E3330 Chemical Structure
E3330, CAS 136164-66-4
Pack Size Availability Price/USD Quantity
1 mg In stock $ 46.00
2 mg In stock $ 66.00
5 mg In stock $ 109.00
10 mg In stock $ 176.00
25 mg In stock $ 319.00
50 mg In stock $ 526.00
100 mg In stock $ 763.00
200 mg In stock $ 1,070.00
500 mg In stock $ 1,590.00
1 mL * 10 mM (in DMSO) In stock $ 90.00
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Purity: 98.83%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.
In vitro E3330 affects hemangioblast development in vitro via inhibition of Ape1 redox activity. [1] E3330 inhibits the growth of human pancreatic cancer cell line PANC1, XPA1, MIAPACA, BxPC3, and PK9. E3330 also promotes exit of cell cycle in PANC1 cells, inhibits the DNA-Binding activity of HIF-1α and migration of pancreatic cancer cells. [2] In JHH6 cells, E3330 prevents the functional activation of NF-κB via the alteration of APE1 subcellular trafficking and reduces IL-6 and IL-8 expression induced by TNF-α and FAs accumulation through blockage of the redox-mediated activation of NF-κB. [3]
In vivo In mice with endotoxin-mediated hepatitis, E3330 (300 mg/kg, p.o.) attenuates the elevation of plasma tumor necrosis factor activity and protectes mice from liver injury. [4] In Rat model, E3330 (100 mg/kg, p.o.) also protectes rats from severe liver injury induced with endotoxin plus galactosamine. [5]
Cell Research PANC1 cells are placed in one well of a 12-well plate and treated with 5 to 30 μM E3330. After a 24, 48, and 72 h of culture, the cells are washed with PBS and stained with trypan blue, and cell viability is examined by counting the live cell numbers.(Only for Reference)
Molecular Weight 378.46
Formula C21H30O6
CAS No. 136164-66-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 70 mg/mL (185 mM)

H2O: <1 mg/mL

Ethanol: 70 mg/mL (185 mM)

TargetMolReferences and Literature

1. Zou GM, et al. Blood. 2007, 109(5), 1917-1922. 2. Zou GM, et al. Mol Cancer Ther. 2008, 7(7), 22012-2021. 3. Cesaratto L, et al. PLoS One. 2013, 8(8), e70909. 4. Nagakawa J, et al. J Pharmacol Exp Ther. 1992, 262(1), 145-150. 5. Nagakawa J, et al. J Pharmacol Exp Ther. 1993, 264(1), 496-500. 6. Guerreiro PS, et al. The APE1 redox inhibitor E3330 reduces collective cell migration of human breast cancer cells and decreases chemoinvasion and colony formation when combined with docetaxel. Chem Biol Drug Des. 2017 Oct;90(4):561-571.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Clinical Compound Library Anti-Cancer Active Compound Library Anti-Cancer Drug Library Clinical Compound Library Inhibitor Library Epigenetics Compound Library Bioactive Compounds Library Max Preclinical Compound Library Anti-Cancer Compound Library ReFRAME Related Library

Related Products

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HIF-1α-IN-2 hydrochloride HIV-IN-7 HIF-2α-IN-9 PHD2-IN-1 VHL-IN-1 PHD-IN-1 PHD-IN-2 HIF-1α-IN-6

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Keywords

E3330 136164-66-4 Cell Cycle/Checkpoint Chromatin/Epigenetic DNA Damage/DNA Repair Metabolism HIF/HIF Prolyl-Hydroxylase DNA/RNA Synthesis pancreatic cancer TNF-α REF-1 NF-κB HIFs Inhibitor HIF-PH Nuclear factor-kappaB APX-3330 APE1 APX 3330 NSCLC cells neuroprotective APX3330 E-3330 endonuclease VEGFR EPCs AP-1 HUVECs Nuclear factor-κB Reactive Oxygen Species E 3330 DNA-binding Activator Protein 1 Hypoxia-inducible factors orally PANC1 anticancer H1975 PCECs inhibit IL-8 Vascular endothelial growth factor receptor inhibitor

 

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