Anti-Cancer Metabolism Compound Library

Catalog No. L2130

Library Compound List Excel SDF

Cancer metabolism has emerged as an important area of research in recent years. Reprogramming of the cellular energy metabolism, essential for cancer cell proliferation and tumor development, constitutes an emerging hallmark of cancer and may serve as a biochemical basis for new therapeutic intervention. From the abnormal aerobic glycolysis effect in tumor cells was first discovered by German scientist Warburg in the early 1920s to now on all aspects of tumor metabolic activity (sugar, fat, amino acids, etc.) analysis and complex metabolic regulation network discovery, the study of tumor metabolism has entered into a more striking height. Distinct metabolic pathways (glycolysis and glutaminolysis), key regulators of aerobic glycolysis (AMPK, mTOR, HIF-1, c-Myc, p53, etc.), and key metabolism enzymes (PKM, HK, PFK, PK, IDH, GLS) might be the key targets for tumor therapeutics. Developing inhibitors targeting dysregulated metabolic enzymes and pathways may represent a promising strategy to overcome drug resistance in cancer therapy.

A unique collection of 1280 cancer cellular metabolism related compounds by TargetMol can be used for cancer related research and high throughput and high content screening for anti-cancer drugs.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Pack Size
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)

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If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at inquiry@targetmol.com

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Product Description

A unique collection of 1280 cancer cellular metabolism related compounds for cancer research and high throughput screening (HTS) and high content screening (HCS);
Bioactivity and safety confirmed by pre-clinical research and clinical trials;
Covers 16 major targets related to cancer cellular metabolism (glucose, proteins, lipids and nucleic acids) including ACL, CA, FASN, GLUT, GLS, HMG-CoA, MAGL, MCTs, PDH, PDK, PKM, etc.; Effect tool for research in cancer metabolism and anti-cancer drug screening.
Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
Structurally diverse, medicinally active, and cell permeable;
NMR and HPLC validated to ensure high purity and quality;

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
Shipped with blue ice

Supporting Files

Library Handling Instructions (635 KB) Targetmol Library Catalog (13.2 MB) Request for Library Compostion in Excel and SDF files

Publications Cited TargetMol Libraries

1. Nature Communications. 2023, 14(1): 3251. 2. Frontiers in Bioengineering and Biotechnology. 2022, 10.. 3. Researchsquare. 2023. 4. Cell Stem Cell. 2022 Apr 29(4) 545–558. 5. Science Bulletin. 2022. 6. Science Translational Medicine. 2022, 14(656): eabn3231. 7. Science Advances. 2023, 9(9): eade3760. 8. Nature. 2020, 582: 289-293. 9. Nature Biotechnology. 2021, 39(11): 1444-1452.

10. Nature Communications. 2022, 13(1): 1-15.. 11. Nature Communications. 2023, 14(1): 1020.. 12. Nature Communications. 2023, 14(1): 2756.. 13. Blood. 2021, 137(11): 1478-1490. 14. Nucleic Acids Research. 2021. 15. Nature Communications. 2023, 14(1): 7574. 16. Advanced Science. 2020, 7(16): 2000925. 17. Angewandte Chemie. 2021. 18. Acta Pharmaceutica Sinica B. 2022. 19. Protein & Cell. 2021, 12(11): 877-888. 20. Bone Research. 2023, 11(1): 54. 21. Pharmacology & Therapeutics. (2021): 107930. 22. Nature Communications. 2021, 12(1): 1-12. 23. Journal of Cell Biology. 2022, 221(5): e202112024. 24. Zhang Z, Aoki H, Umezawa K, et al.Potential role of lipophagy impairment for anticancer effects of glycolysis-suppressed pancreatic ductal adenocarcinoma cells.Cell Death Discovery.2024, 10(1): 166.

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Library Composition

Apoptosis (220)

PI3K (189)

Autophagy (176)

Dehydrogenase (142)

mTOR (99)

Akt (94)

Src (92)

Wnt/beta-catenin (89)

STAT (87)

AMPK (76)

Ras (63)

Bcr-Abl (63)

GSK-3 (57)

CDK (44)

p53 (42)

Endogenous Metabolite (42)

Antibacterial (40)

NF-κB (37)

HIF/HIF Prolyl-Hydroxylase (37)

DNA-PK (36)

Carbonic Anhydrase (36)

S6 Kinase (31)

HIF (29)

VEGFR (27)

Fatty Acid Synthase (27)

JAK (25)

Indoleamine 2,3-Dioxygenase (IDO) (23)

ERK (22)

FLT (22)

Reactive Oxygen Species (22)

ATM/ATR (22)

HMG-CoA Reductase (22)

Glucokinase (21)

c-Kit (21)

Mdm2 (21)

PDGFR (21)

Antibiotic (20)

PDK (20)

Parasite (20)

Raf (20)

p38 MAPK (19)

transporter (17)

Aurora Kinase (17)

DNA/RNA Synthesis (17)

E1/E2/E3 Enzyme (17)

FGFR (16)

Ferroptosis (15)

c-Myc (15)

EGFR (14)

PARP (13)

Rho (13)

PKA (13)

PI4K (12)

MEK (11)

PKC (11)

HIV Protease (11)

MAPK (11)

JNK (11)

Mitophagy (11)

IDO (11)

Isocitrate Dehydrogenase (IDH) (11)

Caspase (11)

TNF (10)

IL Receptor (10)

IGF-1R (10)

PPAR (10)

P450 (10)

ROCK (9)

Potassium Channel (9)

Casein Kinase (9)

Calcium Channel (9)

COX (9)

FAK (8)

c-RET (8)

Virus Protease (8)

BCL (8)

Chk (8)

Antifungal (8)

MMP (7)

Phosphatase (7)

Influenza Virus (7)

Interleukin (7)

Stearoyl-CoA Desaturase (SCD) (7)

PKM (7)

Mitochondrial Metabolism (6)

c-Met/HGFR (6)

Microtubule Associated (6)

c-Fms (6)

MAGL (6)

HCV Protease (6)

PTEN (6)

Sirtuin (6)

PDE (6)

AChR (6)

Glutaminase (6)

HDAC (5)

HSV (5)

Somatostatin (5)

SIK (5)

NO Synthase (5)

Topoisomerase (5)

MELK (5)

Syk (5)

IκB/IKK (4)

SARS-CoV (4)

Lipoxygenase (4)

Prostaglandin Receptor (4)

SGK (4)

Hck (4)

Trk receptor (4)

TLR (4)

Epigenetic Reader Domain (4)

CAT (3)

Ephrin Receptor (3)

P-gp (3)

LDL (3)

NPC1L1 (3)

Lipid (3)

Tyrosinase (3)

Aryl Hydrocarbon Receptor (3)

Drug Metabolite (3)

TGF-beta/Smad (3)

Hexokinase (3)

Nucleoside Antimetabolite/Analog (3)

Nrf2 (3)

Antiviral (3)

Lipase (3)

Antioxidant (3)

Sodium Channel (3)

IAP (3)

HBV (3)

AChE (3)

PLK (3)

Porcupine (3)

Adrenergic Receptor (3)

Antifolate (3)

Glucosidase (3)

GABA Receptor (3)

ACK (2)

Adenosine Receptor (2)

Cannabinoid Receptor (2)

cAMP (2)

CaMK (2)

Beta-Secretase (2)

BTK (2)

ATP Citrate Lyase (2)

Beta Amyloid (2)

ALK (2)

Anti-infection (2)

BACE (2)

UGT (2)

Tyrosine Kinases (2)

Serine Protease (2)

CRISPR/Cas9 (2)

NOS (2)

DYRK (2)

Serine/threonin kinase (2)

SGLT (2)

GTPase (2)

S1P Receptor (2)

GluR (2)

Integrin (2)

Gamma-secretase (2)

Estrogen Receptor/ERR (2)

TAM Receptor (2)

RSV (2)

Reverse Transcriptase (2)

LRRK2 (2)

ROS (2)

DUB (2)

DNA Alkylator/Crosslinker (2)

Transferase (2)

CSF-1R (2)

MLK (2)

Chloride channel (2)

NADPH-oxidase (2)

IFNAR (2)

RAAS (1)

ROS Kinase (1)

Tie-2 (1)

Pyroptosis (1)

RIP kinase (1)

Retinoid Receptor (1)

TRP/TRPV Channel (1)

5-HT Receptor (1)

Proton pump (1)

Cysteine Protease (1)

FXR (1)

FAAH (1)

Estrogen/progestogen Receptor (1)

Epoxide Hydrolase (1)

Dopamine Receptor (1)

DNA Alkylation (1)

DHFR (1)

DAPK (1)

CXCR (1)

Glutathione Peroxidase (1)

cholecystokinin (1)

CFTR (1)

cell cycle arrest (1)

BCRP (1)

ATPase (1)

Arginase (1)

Aquaporin (1)

Androgen Receptor (1)

AhR (1)

Glucocorticoid Receptor (1)

Glutathione reductase (1)

Pim (1)

MAO (1)

PERK (1)

PD-1/PD-L1 (1)

p97 (1)

OCT (1)

OAT (1)

NMDAR (1)

Myosin (1)

MRP (1)

Methionine Adenosyltransferase (MAT) (1)

KLF (1)

GPX (1)

Kinesin (1)

iGluR (1)

Hydroxylase (1)

HSP (1)

Histone Acetyltransferase (1)

HER (1)

Hedgehog/Smoothened (1)

hCE (1)

Guanylate cyclase (1)

YAP (1)

Library Information Sample

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty