Search Result

Search Results for " pgp "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T28396	PGP-4008	PGP 4008,PGP4008	P-gp
	PGP-4008 is a selective and potent P-glycoprotein (Pgp) inhibitor that inhibits tumor growth by co-administration with Doxorubicin.		P-gp
T16466	Penicillin G Procaine	PGP	Others
	Penicillin G Procaine is a β-lactam antibiotic and is a crystalline complex produced by chemically combining penicillin G with procaine.		Others
T12341	P-gp inhibitor 1		Others , P-gp
	P-gp inhibitor 1 inhibits reversing P-glycoprotein-mediated multidrug resistance with an EC50 of 57.9 nM (K562/A02 cells).		Others , P-gp
T8426	Encequidar	HM30181,HM30181A	P-gp
	Encequidar (HM30181A) is a potent and selective P-glycoprotein inhibitor.		P-gp
T16561	Polyoxyethylene stearate	POES	Antibacterial , P-gp
	Polyoxyethylene stearate (POES) is an agent of non-ionic emulsifying.		Antibacterial , P-gp
T6287	Tariquidar	XR9576	P-gp
	Tariquidar (XR9576)(Kd=5.1 nM) is a specific and effective non-competitive inhibitor of P-glycoprotein. It can reverse drug resistance in MDR cell Lines.		P-gp
T11071	Dofequidar fumarate	MS-209	P-gp
	Dofequidar fumarate (MS-209)(MS-209 fumarate), a quinoline-based compound administered orally, is known for counteracting multidrug resistance (MDR) through the inhibition of ABCB1/P-glycoprotein (P-gp) and ABCC1/MDR-ass...		P-gp
T0351	Risperidone	Risperidal,R 64 766	Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , P-gp
	Risperidone (R 64 766) is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent.
T4059	Selamectin	UK-124114	Chloride channel , P-gp , Parasite
	Selamectin (UK-124114) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes. In an H. contortus larval development assay, sel...		Chloride channel , P-gp , Parasite
T13383	Zamicastat	BIA 5-1058	BCRP , Hydroxylase , P-gp
	Zamicastat (BIA 5-1058) is an inhibitor of dopamine β-hydroxylase (DBH), and is also a concentration-dependent dual inhibitor of P-gp and BCRP(IC50 values of 73.8 μM and 17.0 μM, respectively).		BCRP , Hydroxylase , P-gp
T8389	Trifluoperazine	trifluoroperazine	CaMK , Dopamine Receptor , Influenza Virus , Adrenergic Receptor , P-gp , Autophagy
	Trifluoperazine (trifluoroperazine) is a Dopamine D2 receptor inhibitor(IC50 : 1.2 nM), and Treatment of schizophrenia.
T11578L	Encequidar mesylate	HM30181 mesylate,HM30181A mesylate	P-gp
	Encequidar mesylate (HM30181A mesylate) is a competitive P-glycoprotein inhibitor.		P-gp
T12340	P-gp modulator 1		Others
	P-gp modulator 1 is a high affinity and orally available P-glycoprotein (Pgp) modulator		Others
T0100L	Atazanavir	Zrivada,Reyataz,Latazanavir,BMS-232632	P450 , SARS-CoV , HIV Protease , P-gp
	Atazanavir (BMS-232632)(BMS-232632) is an highly effective HIV-1 protease inhibitor.		P450 , SARS-CoV , HIV Protease , P-gp
T1634	Glibenclamide	Glyburide	Potassium Channel , Mitochondrial Metabolism , CFTR , P-gp , Autophagy
	Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.
T20656	Verapamil	NSC 135784,NSC-135784,CP-16533-1,(±)-Verapamil	P450 , Calcium Channel , P-gp
	Verapamil (CP-16533-1) is a calcium channel blocker and an orally active and effective inhibitor of P-gp. Verapamil inhibits CYP3A4 and can be used in studies about the treatment of high blood pressure, heart arrhythmias...		P450 , Calcium Channel , P-gp
T16339	Norverapamil hydrochloride	(±)-Norverapamil hydrochloride,D591 hydrochloride	Calcium Channel , P-gp , Drug Metabolite
	Norverapamil hydrochloride (D591 hydrochloride) ((±)-Norverapamil hydrochloride) is an N-demethylated metabolite of Verapamil and it is an L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor.		Calcium Channel , P-gp , Drug Metabolite
T1010	Verapamil hydrochloride	Manidon,(±)-Verapamil hydrochlorid,Verapamil HCl,Calcan hydrochloride	P450 , Calcium Channel , P-gp
	Verapamil hydrochloride (Verapamil HCl) is a calcium channel blocker that is a class IV anti-arrhythmia agent.		P450 , Calcium Channel , P-gp
T1222	Trifluoperazine dihydrochloride	Trifluoperazine 2HCl,SKF5019,Urinox	CaMK , Dopamine Receptor , Influenza Virus , Adrenergic Receptor , P-gp , Autophagy
	Trifluoperazine dihydrochloride (SKF5019) is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.
T0100	Atazanavir sulfate	BMS-232632,BMS-232632 sulfate	P450 , SARS-CoV , HIV Protease , P-gp
	Atazanavir sulfate (BMS-232632 sulfate) is an azapeptide and HIV-PROTEASE INHIBITOR that is used in the treatment of HIV INFECTIONS and AIDS in combination with other ANTI-HIV AGENTS.		P450 , SARS-CoV , HIV Protease , P-gp
T2657	Elacridar	GW0918,GW120918,GF120918,GG918	BCRP , P-gp
	Elacridar (GG918) (GF120918) is an effective BCRP and P-gp (MDR-1) inhibitor.		BCRP , P-gp
T6018	Zosuquidar trihydrochloride	Zosuquidar (LY335979) 3HCl,RS 33295-198 trihydrochloride,RS 33295-198 (D06387) 3HCl,Zosuquidar 3HCl,LY-335979 trihydrochloride	P-gp
	Zosuquidar trihydrochloride (LY-335979 trihydrochloride) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM. Phase 3.		P-gp
T74475	M7GpppGpG
	M7GpppGpG, a trinucleotide cap analogue and oligonucleotide, protects against premature degradation by 5′-exonucleases and facilitates pre-mRNA splicing, mRNA transport, and protein biosynthesis initiation by recruiting ...
T35959	PGPC	1-Palmitoyl-2-glutaryl phosphatidylcholine	Others
	PGPC (1-Palmitoyl-2-glutaryl phosphatidylcholine) is an oxidized phospholipid and activates peroxisome proliferator-activated receptor in a concentration-dependent manner.		Others
T38122	5'-pGpG (sodium salt)
	5'-pGpG is a linearized form of cyclic di-GMP, a bacterial second messenger that activates the host innate immune system through stimulator of interferon genes (STING).1,2,3It is a metabolite of cyclic di-GMP formedviahy...
T16744	Rhodamine 6G	Basic Red 1	Others
	Rhodamine 6G (Basic Red 1) is a rhodamine analog useful in Pgp efflux assays. It can be widely used in characterizing the kinetics of MRP1- mediated efflux as a laser dye and potential mitochondrial probe.		Others
T16352	NSC23925		Nrf2
	NSC23925 is a selective and effective inhibitor of P-glycoprotein (Pgp).		Nrf2
T79261	P-gp inhibitor 15
	P-gp Inhibitor 15 (compound 7a), a nonsubstrate inhibitor of P-glycoprotein (Pgp), inhibits Pgp-ATPase activity and interferes with Pgp-mediated Rhodamine123 efflux. Additionally, this compound enhances the inhibitory ef...
T12714	Reversan	CBLC4H10	Others
	Reversan is a potent and nontoxic multidrug inhibitor of resistance-associated protein 1 (MRP1) and P-glycoprotein (Pgp).		Others
T33754	NSC-57969	NSC57969
	NSC-57969 is a MDR-selective agent, exhibiting a robust Pgp-dependent toxic activity across diverse cancer cell lines.
T26229	ST7710AA1	ST-7710-AA1,ST 7710 AA1
	ST7710AA1 is a PARP-1 inhibitor that acts by showing significant in vitro target inhibition and capability to substantially bypass the multidrug resistance mediated by Pgp.
T61956	BACE1/2-IN-1
	BACE1/2-IN-1 (compound 34) is an effective BACE1 and BACE2 inhibitor with IC50 of 0.01 and 0.0053 μM, respectively. BACE1/2-IN-1 has lower Pgp efflux ratio and improved passive permeability. The metabolic stability of BA...
T68273	BNC105P
	BNC105P is a benzofuran-based vascular disrupting agent (VDA) prodrug with potential anti-vascular and antineoplastic activities. Upon administration vascular disrupting agent BNC105P, the disodium phosphate ester of BNC...

Compounds

PGP-4008

T28396

Synonym: PGP 4008,PGP4008

Target: P-gp

Penicillin G Procaine

Synonym: HM30181,HM30181A

Target: P-gp

Polyoxyethylene stearate

T16561

Synonym: POES

Target: Antibacterial, P-gp

Synonym: Risperidal,R 64 766

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, P-gp

Selamectin

T4059

Synonym: UK-124114

Target: Chloride channel, P-gp, Parasite

Zamicastat

T13383

Synonym: BIA 5-1058

Target: BCRP, Hydroxylase, P-gp

Trifluoperazine

T8389

Synonym: trifluoroperazine

Target: CaMK, Dopamine Receptor, Influenza Virus, Adrenergic Receptor, P-gp, Autophagy

Encequidar mesylate

T11578L

Synonym: HM30181 mesylate,HM30181A mesylate

Synonym: Zrivada,Reyataz,Latazanavir,BMS-232632

Target: P450, SARS-CoV, HIV Protease, P-gp

Glibenclamide

T1634

Synonym: Glyburide

Target: Potassium Channel, Mitochondrial Metabolism, CFTR, P-gp, Autophagy

Verapamil

T20656

Synonym: NSC 135784,NSC-135784,CP-16533-1,(±)-Verapamil

Target: P450, Calcium Channel, P-gp

Norverapamil hydrochloride

T16339

Synonym: (±)-Norverapamil hydrochloride,D591 hydrochloride

Target: Calcium Channel, P-gp, Drug Metabolite

Verapamil hydrochloride

T1010

Synonym: Manidon,(±)-Verapamil hydrochlorid,Verapamil HCl,Calcan hydrochloride

Target: P450, Calcium Channel, P-gp

Trifluoperazine dihydrochloride

T1222

Synonym: Trifluoperazine 2HCl,SKF5019,Urinox

Target: CaMK, Dopamine Receptor, Influenza Virus, Adrenergic Receptor, P-gp, Autophagy

Atazanavir sulfate

T0100

Synonym: BMS-232632,BMS-232632 sulfate

Target: P450, SARS-CoV, HIV Protease, P-gp

Elacridar

T2657

Synonym: GW0918,GW120918,GF120918,GG918

Target: BCRP, P-gp

Zosuquidar trihydrochloride

T6018

Synonym: Zosuquidar (LY335979) 3HCl,RS 33295-198 trihydrochloride,RS 33295-198 (D06387) 3HCl,Zosuquidar 3HCl,LY-335979 trihydrochloride

Synonym: 1-Palmitoyl-2-glutaryl phosphatidylcholine

Target: Others

5'-pGpG (sodium salt)

Synonym: ST-7710-AA1,ST 7710 AA1

Cat No.	Product Name	Synonyms	Targets
TN1651	Furanodiene		Apoptosis , PARP , Reactive Oxygen Species , Caspase , CDK , P-gp
	Furanodiene has anti-inflammatory and antioxidant activities, it is active against gram-positive bacteria and Candida albicans.
T3S0012	Coniferyl ferulate		P-gp , GST
	Coniferyl ferulate is a strong inhibitor of glutathione S-transferase (GST) isolated from Radix Angelicae sinensis. It shows strong inhibition of human placental GST (IC50: 0.3 μM). It also reverses multidrug resistance ...		P-gp , GST
T2S0223	Isosinensetin	6-Demethoxynobiletin	Antioxidant , HIV Protease , Antibacterial , P-gp
	1. Isosinensetin (6-Demethoxynobiletin) shows antioxidant and HIV-1 protease inhibiting activities.		Antioxidant , HIV Protease , Antibacterial , P-gp
TN4761	Phellamurin		P-gp
	Phellamurin inhibits intestinal P-glycoprotein in a dose-dependent manner, there is a serious interaction occurred between Phellamurin with cyclosporin, to ensure the efficacy of cyclosporin, we suggest that the coadmini...		P-gp
TJS1159	Chrysosplenetin	Chrysosptertin B	P450 , Ferroptosis , P-gp
	Chrysosplenetin is a metabolic inhibitor of artemisinin.		P450 , Ferroptosis , P-gp
T2S0271	Voacamine	Voacanginine	Cannabinoid Receptor , P-gp
	Voacamine (Voacanginine) is an indole alkaloid. Voacamine exhibits potent cannabinoid CB1 receptor antagonistic activity. Voacamine also inhibits P-glycoprotein (P-gp) action in multidrug-resistant tumor cells.Voacangini...		Cannabinoid Receptor , P-gp
T3002	Piperine	1-Piperoylpiperidine,Bioperine	P450 , Endogenous Metabolite , P-gp , Autophagy
	Piperine (Bioperine) , a alkaloid, has been used in trials studying the treatment of multiple myeloma and deglutition disorders.		P450 , Endogenous Metabolite , P-gp , Autophagy
T2S1200	Sinapine		Antioxidant , P-gp , AChE
	1. Sinapine, an alkaloid from seeds of the cruciferous species, can be used as an effective natural compound for chemo-resistance. 2. Sinapine has antioxidant and radio-protective activities.		Antioxidant , P-gp , AChE
T4034	Solamargine	Solamargin,δ-Solanigrine	Apoptosis , p38 MAPK , P-gp , STAT
	Solamargine (δ-Solanigrine) is a major steroidal alkaloid glycoside extracted from a traditional Chinese medicine herb, Solanum nigrum L. (SNL); has been shown to inhibit growth and induce apoptosis of various cancer cel...		Apoptosis , p38 MAPK , P-gp , STAT
T3392	Sinapine thiocyanate		P-gp , AChE
	Sinapine Thiocyanate, is a derivative of Sinapine (S486605), an alkaloidal amine found in black mustard seeds. It is the choline ester of Sinapic Acid (S486800). It is also a phenolic-chloine conjugates, acting as anti-o...		P-gp , AChE
T2799	(20S)-Protopanaxadiol	20-Epiprotopanaxadiol,20(S)-APPD	Apoptosis , Reactive Oxygen Species , P-gp
	(20S)-Protopanaxadiol (20-Epiprotopanaxadiol) (20-Epiprotopanaxadiol), an apoptosis inducer, is an aglycon metabolic derivative of the protopanaxadiol-type ginseng saponin.		Apoptosis , Reactive Oxygen Species , P-gp
TN1525	Convallatoxin		NF-κB , P-gp , PPAR
	Convallatoxin is a natural product		NF-κB , P-gp , PPAR
TN1757	Hypophyllanthin		Potassium Channel , Calcium Channel , P-gp
	Hypophyllanthin and phyllanthin have antitumour effects against Ehrlich Ascites Carcinoma in mice.		Potassium Channel , Calcium Channel , P-gp
TCS2336	Evodine		P-gp
	1. Evodine has antinociceptive activity.		P-gp
T4085	Paris saponin VII	Chonglou Saponin VII,Polyphyllin-VII,Dioscinin,Paris saponin-VII	Apoptosis , BCL , Others , PARP , p38 MAPK , Akt , Caspase , P-gp , Autophagy
	Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.
TN2256	Taccalonolide B		Microtubule Associated
	Taccalonolide B is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug-resistance protein (MRP7). Taccalonolide B inhibits growth of SK-OV-3 cells with an IC50 of 208 nM.		Microtubule Associated
TN2254	Taccalonolide A		Apoptosis , Microtubule Associated
	Taccalonolide A is the first microtubule stabilizing agent to be discovered from a plant since identification of the mechanism of action of paclitaxel and it is the first natural product steroid identified to have these ...		Apoptosis , Microtubule Associated
TN4819	(-)-Praeruptorin A		ATPase , IL Receptor , Calcium Channel , P-gp
	(-)-Praeruptorin A has anti-inflammatory, anti-contractile and anti-hyperplasia activities, it exerts distinct relaxant effects on isolated rat aorta rings dependent on endothelium and nitric oxide synthesis;it also can ...		ATPase , IL Receptor , Calcium Channel , P-gp
TN4749	Pepluanin A		P-gp
	Pepluanin A, shows a very high activity for a jatrophane diterpene, outperforming cyclosporin A by a factor of at least 2 in the inhibition of Pgp-mediated daunomycin transport.		P-gp
T15097	Deoxynivalenol	Vomitoxin,4-Deoxynivalenol
	Deoxynivalenol (Vomitoxin) is a mycotoxin produced by Fusarium spp. of the single trichothecene family and is commonly found in contaminated food and feed.Deoxynivalenol crosses the intestinal mucosa via a cellular bypas...

Natural Products

Furanodiene

TN1651

Synonym:

Target: Apoptosis, PARP, Reactive Oxygen Species, Caspase, CDK, P-gp

Synonym: 6-Demethoxynobiletin

Target: Antioxidant, HIV Protease, Antibacterial, P-gp

Synonym: Chrysosptertin B

Target: P450, Ferroptosis, P-gp

Voacamine

T2S0271

Synonym: Voacanginine

Target: Cannabinoid Receptor, P-gp

Piperine

T3002

Synonym: 1-Piperoylpiperidine,Bioperine

Target: P450, Endogenous Metabolite, P-gp, Autophagy

Sinapine

T2S1200

Synonym:

Target: Antioxidant, P-gp, AChE

Solamargine

T4034

Synonym: Solamargin,δ-Solanigrine

Target: Apoptosis, p38 MAPK, P-gp, STAT

(20S)-Protopanaxadiol

T2799

Synonym: 20-Epiprotopanaxadiol,20(S)-APPD

Target: Apoptosis, Reactive Oxygen Species, P-gp

Convallatoxin

TN1525

Synonym:

Target: NF-κB, P-gp, PPAR

Hypophyllanthin

TN1757

Synonym:

Target: Potassium Channel, Calcium Channel, P-gp

Synonym: Chonglou Saponin VII,Polyphyllin-VII,Dioscinin,Paris saponin-VII

Target: Apoptosis, BCL, Others, PARP, p38 MAPK, Akt, Caspase, P-gp, Autophagy

Taccalonolide B

TN2256

Synonym:

Target: Microtubule Associated

Taccalonolide A

TN2254

Synonym:

Target: Apoptosis, Microtubule Associated

(-)-Praeruptorin A

TN4819

Synonym:

Target: ATPase, IL Receptor, Calcium Channel, P-gp

Synonym: Vomitoxin,4-Deoxynivalenol

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-05047	CD44 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	CD44 is a type I transmembrane protein and a member of the cartilage link protein family. It is involved in cell-cell and cell-matrix interactions and signal transduction. Several CD44 ligands have been identified. The m...
TMPK-00518	CD44 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	CD44 is a hyaluronan binding cell surface signal transducing receptor that influences motility, cell survival and proliferation as well as the formation of tumor microenvironment. CD44 contains two variable regions encod...
TMPY-01547	UCHL1 Protein, Human, Recombinant (His)	Human	E. coli
	Ubiquitin carboxyl-terminal hydrolase isozyme L1, also known as UCH-L1, Ubiquitin thioesterase L1, PGP9.5 and UCHL1, is a deubiqutinating enzyme with important functions in recycling of ubiquitin. Regulated proteolysis b...
TMPH-00393	pGP3-D Protein, Chlamydia trachomatis, Recombinant (His)	Chlamydia trachomatis	Yeast
	pGP3-D Protein, Chlamydia trachomatis, Recombinant (His) is expressed in Yeast with N-terminal 10xHis tag. The predicted molecular weight is 30.3 kDa. Accession number: P0CE18
TMPK-01553	HLA-A*02:01&B2M&GP100 (YLEPGPVTA) Monomer Protein, Human, MHC (His & Avi), Biotinylated	Human	HEK293
	Glycoprotein 100, gp100 or Melanocyte protein PMEL is 661 amino acids long and is a type I transmembrane glycoprotein enriched in melanosomes, which are the melanin-producing organelles in melanocytes. This protein is in...
TMPK-01540	HLA-A*02:01&B2M&GP100 (YLEPGPVTA) Tetramer Protein, Human, MHC (His & Avi)	Human	HEK293
	Glycoprotein 100, gp100 or Melanocyte protein PMEL is 661 amino acids long and is a type I transmembrane glycoprotein enriched in melanosomes, which are the melanin-producing organelles in melanocytes. This protein is in...
TMPK-01551	HLA-A*02:01&B2M&GP100 (YLEPGPVTA) Monomer Protein, Human, MHC (His & Avi)	Human	HEK293
	Glycoprotein 100, gp100 or Melanocyte protein PMEL is 661 amino acids long and is a type I transmembrane glycoprotein enriched in melanosomes, which are the melanin-producing organelles in melanocytes. This protein is in...
TMPH-00394	pGP3-D Protein, Chlamydia trachomatis, Recombinant (E. coli, His)	Chlamydia trachomatis	E. coli
	pGP3-D Protein, Chlamydia trachomatis, Recombinant (E. coli, His) is expressed in E. coli with N-terminal 6xHis tag. The predicted molecular weight is 31.9 kDa. Accession number: P0CE18
TMPY-02602	PTPMT1 Protein, Human, Recombinant (His)	Human	E. coli
	PTPMT1 (PTP localized to the Mitochondrion 1) is a member of the protein tyrosine phosphatase superfamily that is localized exclusively to the mitochondrion. It has been recently reported that PTPMT1 dephosphorylates pho...