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Zamicastat

Zamicastat
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Purity:97.43%

Zamicastat

Catalog No. T13383Cas No. 1080028-80-3
Zamicastat (BIA 5-1058) is an inhibitor of dopamine β-hydroxylase (DBH), and is also a concentration-dependent dual inhibitor of P-gp and BCRP(IC50 values of 73.8 μM and 17.0 μM, respectively).
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Pack SizePrice/USDAvailabilityQuantity
1 mg$101In Stock
5 mg$223In Stock
10 mg$397In Stock
25 mg$665In Stock
50 mg$947In Stock
100 mg$1,280In Stock
1 mL x 10 mM (in DMSO)$233In Stock
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Product Introduction

Bioactivity
Description
Zamicastat (BIA 5-1058) is an inhibitor of dopamine β-hydroxylase (DBH), and is also a concentration-dependent dual inhibitor of P-gp and BCRP(IC50 values of 73.8 μM and 17.0 μM, respectively).
In vivo
In the Dahl SS rat, Zamicastat (10, 30 and 100 mg/kg/day; oral bolus, 7 days) is tested acutely against salt-induced hypertension. Zamicastat produces a dose-dependent decrease in blood pressure[2].
AliasBIA 5-1058
Chemical Properties
Molecular Weight401.47
FormulaC21H21F2N3OS
Cas No.1080028-80-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 150 mg/mL (373.63 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4908 mL12.4542 mL24.9085 mL124.5423 mL
5 mM0.4982 mL2.4908 mL4.9817 mL24.9085 mL
10 mM0.2491 mL1.2454 mL2.4908 mL12.4542 mL
20 mM0.1245 mL0.6227 mL1.2454 mL6.2271 mL
50 mM0.0498 mL0.2491 mL0.4982 mL2.4908 mL
100 mM0.0249 mL0.1245 mL0.2491 mL1.2454 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg,each TargetMol | Animal experiments animal weighs 20 g, and the dosage volume is 100 μL. A total of TargetMol | Animal experiments 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL.
Mother liquor preparation method: 2 mg of drug dissolved in 50 μLDMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μLDMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μLTween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify.
1 Enter information below:
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