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Risperidone

Catalog No. T0351 CAS 106266-06-2

Synonyms: Risperidal, R 64 766

Risperidone (R 64 766) is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent.

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Risperidone, CAS 106266-06-2

Pack Size	Availability	Price/USD
10 mg	In stock	$ 43.00
25 mg	In stock	$ 54.00
50 mg	In stock	$ 85.00
100 mg	In stock	$ 130.00
200 mg	In stock	$ 213.00
500 mg	In stock	$ 358.00
1 mL * 10 mM (in DMSO)	In stock	$ 48.00

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Purity: 99.51%

Biological Description

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Description	Risperidone (R 64 766) is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent.
Targets&IC50	D2 receptor:3.57 nM(Ki), α2C-adrenoceptor:1.3 nM(Ki), D2L receptor:4.16 nM(Ki), D3 receptor:3.6 nM(Ki), 5-HT2A:0.17 nM(Ki)
In vitro	In rats, Risperidone (0.5 mg/kg) results in diminished weight gain and enhanced UCP1 gene expression in BAT, along with elevated serum prolactin levels. At a dose of (0.05 mg/kg), Risperidone increases food intake and leptin gene expression in white adipose tissue without affecting the rate of weight gain.
In vivo	In activated microglia, Risperidone significantly inhibits the production of NO and pro-inflammatory cytokines. In Caco-2 cells, Risperidone (1-50 mM) notably enhances the intracellular accumulation of Rh123 by inhibiting the activity of P-gp, with an IC50 value of 5.87 mM.

Synonyms	Risperidal, R 64 766
Molecular Weight	410.48
Formula	C23H27FN4O2
CAS No.	106266-06-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 4.1 mg/mL (10 mM)

Ethanol: 4.1 mg/mL (10 mM)

References and Literature

1. Angelucci F, et al. J Neurosci Res,2000, 60(6), 783-794. 2. Tarazi FI, et al. J Pharmacol Exp Ther,2001, 297(2), 711-717. 3. Kato T, et al. Schizophr Res,2007, 92(1-3), 108-115. 4. Zhu HJ, et al. Neuropsychopharmacology,2007, 32(4), 757-764. 5. Baptista T, et al. Brain Res,2002, 957(1), 144-151.

Citations

1. Wesołowska A, Rychtyk J, Gdula-Argasińska J, et al Effect of 5-HT6 Receptor Ligands Combined with Haloperidol or Risperidone on Antidepressant-/Anxiolytic-Like Behavior and BDNF Regulation in Hippocampus and Prefrontal Cortex of Rats. Neuropsychiatric Disease and Treatment. 2021, 17: 2105. 2. Partyka A, Górecka K, Gdula-Argasińska J, et al.Selective 5-HT6 Receptor Ligands (Agonist and Antagonist) Show Different Effects on Antipsychotic Drug-Induced Metabolic Dysfunctions in Rats.Pharmaceuticals.2023, 16(2): 154.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library GPCR Compound Library Anti-Cancer Clinical Compound Library EMA Approved Drug Library Drug Repurposing Compound Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Inhibitor Library Anti-Obesity Compound Library Serotonin Receptor-Targeted Compound Library

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Keywords

Risperidone 106266-06-2 GPCR/G Protein Membrane transporter/Ion channel Neuroscience 5-HT Receptor Dopamine Receptor P-gp Adrenergic Receptor inhibit Cluster of differentiation 243 Multidrug resistance protein 1 5-hydroxytryptamine Receptor CD243 Risperidal MDR1 R 64 766 Inhibitor P-glycoprotein Serotonin Receptor Pgp ABCB1 inhibitor

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