Home Tools
Log in


Catalog No. T3002   CAS 94-62-2
Synonyms: 1-Piperoylpiperidine, Bioperine

Piperine (Bioperine) , a alkaloid, has been used in trials studying the treatment of multiple myeloma and deglutition disorders.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Piperine Chemical Structure
Piperine, CAS 94-62-2
Pack Size Availability Price/USD Quantity
100 mg In stock $ 29.00
1 mL * 10 mM (in DMSO) In stock $ 30.00
Bulk Inquiry
Get quote
Select Batch  
Purity: 100%
Purity: 97.79%
Contact us for more batch information
Biological Description
Chemical Properties
Storage & Solubility Information
Description Piperine (Bioperine) , a alkaloid, has been used in trials studying the treatment of multiple myeloma and deglutition disorders.
Targets&IC50 P-glycoprotein:61.94±0.054 μg/mL, CYP3A4:61.94±0.054 μg/mL
Cell Research Standard solution is prepared by dissolving 10 mg of piperine in 100 mL of methanol. The MTT assay is carried out to measure cell viability. Ten thousand cells in 100 μL of DMEM media are seeded in the wells of a 96-well plate. After 24 h, existing media is removed and 100 μL of various concentrations of piperine (20–100 μg/mL) are added and incubated for 48 h at 37 °C in a CO2 incubator. Control cells are supplemented with 0.05 % DMSO vehicle. At the 48th hour of incubation, MTT (10 μL of 5 mg/mL) is added to the plate. The contents of the plate are pipetted out carefully, the formazan crystals formed are dissolved in 100 μL of DMSO, and the absorbance is measured at 550 nm in a microplate reader[1].
Synonyms 1-Piperoylpiperidine, Bioperine
Molecular Weight 285.34
Formula C17H19NO3
CAS No. 94-62-2


Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 57 mg/mL (199.76 mM)

DMSO: 57 mg/mL (199.76 mM)

H2O: <1 mg/mL

TargetMolReferences and Literature

1. Bhardwaj RK, et al. J Pharmacol Exp Ther, 2002, 302(2), 645-650. 2. Sunila ES, et al. J Ethnopharmacol, 2004, 90(2-3), 339-346. 3. Piyachaturawat P, et al. Toxicol Lett, 1983, 16(3-4), 351-359. 6. Zhai WJ, et al. Piperine Plays an Anti-Inflammatory Role in Staphylococcus aureus Endometritis by Inhibiting Activation of NF-κB and MAPK Pathways in Mice. Evid Based Complement Alternat Med. 2016;2016:8597208.


1. Gu D R, Yang H, Kim S C, et al. Water Extract of Piper longum Linn Ameliorates Ovariectomy-Induced Bone Loss by Inhibiting Osteoclast Differentiation. Nutrients. 2022, 14(17): 3667.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Metabolism Compound Library Human Endogenous Metabolite Compound Library Plus Gut Microbial Metabolite Library Preclinical Compound Library Traditional Mongolian Medicine Compound Library Anti-Tumor Natural Product Library Tibetan medicine Compound Library

Related Products

Related compounds with same targets
Harman hydrochloride Ginsenoside C-K Resveratroloside Guanfu base A Pisatin 8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate Cephaeline dihydrochloride BI 653048

TargetMolDose Conversion

You can also refer to dose conversion for different animals. More

TargetMol In vivo Formulation Calculator (Clear solution)

Step One: Enter information below
Average weight of animals
Dosing volume per animal
Number of animals
Step Two: Enter the in vivo formulation
% Tween 80
% ddH2O
Calculate Reset


Molarity Calculator
Dilution Calculator
Reconstitution Calculation
Molecular Weight Calculator

Molarity Calculator allows you to calculate the

  • Mass of a compound required to prepare a solution of known volume and concentration
  • Volume of solution required to dissolve a compound of known mass to a desired concentration
  • Concentration of a solution resulting from a known mass of compound in a specific volume
See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box


Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box


Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.


Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.


Piperine 94-62-2 Autophagy Membrane transporter/Ion channel Metabolism Neuroscience P450 Endogenous Metabolite P-gp Cluster of differentiation 243 Inhibitor Multidrug resistance protein 1 CD243 ABCB1 1-Piperoylpiperidine P-glycoprotein inhibit Pgp MDR1 Bioperine inhibitor