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Trifluoperazine

Name: Trifluoperazine
Brand: TargetMol
SKU: T8389
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8389Cas No. 117-89-5

Alias trifluoroperazine

Trifluoperazine (trifluoroperazine) is a Dopamine D2 receptor inhibitor(IC50 : 1.2 nM), and Treatment of schizophrenia.

Trifluoperazine

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Purity: 99.46%

Catalog No. T8389Alias trifluoroperazineCas No. 117-89-5

Trifluoperazine (trifluoroperazine) is a Dopamine D2 receptor inhibitor(IC50 : 1.2 nM), and Treatment of schizophrenia.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$37	In Stock	In Stock
2 mg	$48	-	In Stock
5 mg	$74	In Stock	In Stock
10 mg	$111	In Stock	In Stock
25 mg	$202	In Stock	In Stock
50 mg	$316	In Stock	In Stock
100 mg	$478	-	In Stock
200 mg	$689	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.46%

Color:Yellow

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COA HNMR HPLC

Product Introduction

Trifluoperazine AI Summary

Trifluoperazine exhibits a diverse range of bioactivities, with significant inhibitory effects on various biological targets. It inhibits ADP-induced platelet aggregation with an IC50 value of 201800.0 nM and demonstrates high aqueous solubility, indicated by a Log S value of -4.52. It displays antipsychotic activity in vivo, blocking conditioned avoidance response (CAR) in rats with an ED50 of 0.52 mg/kg and inducing catalepsy with an ED50 of 0.5 mg/kg. Trifluoperazine has a high binding affinity towards dopamine receptor D2 (Ki = 2.2 nM) and 5-hydroxytryptamine 2 receptor (Ki = 5.2 nM), among others. It also inhibits mast cell degranulation, with IC50 values of 10100.0 nM for histamine release and 12800.0 nM for beta-glucuronidase release, indicating potential anti-inflammatory and anti-allergic properties. Additionally, Trifluoperazine inhibits protein kinase C (PKC) with an IC50 of 500000.0 nM and inhibit several other kinases and enzymes in various contexts. It shows antimicrobial activity against pathogens like Plasmodium falciparum and Mycobacterium tuberculosis and has significant binding activity towards several receptors and proteins. Trifluoperazine also exhibits lipophilic behavior (LogD7.4 = 4.31) and high plasma protein binding, suggesting extensive tissue distribution. Furthermore, it has shown potential in various therapeutic applications including anti-inflammatory, antimicrobial, antipsychotic, and anti-parasitic treatments..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Trifluoperazine (trifluoroperazine) is a Dopamine D2 receptor inhibitor(IC50 : 1.2 nM), and Treatment of schizophrenia.
Targets&IC50	D2:1.2 nM
Synonyms	trifluoroperazine

Chemical Properties

Molecular Weight	407.5
Formula	C₂₁H₂₄F₃N₃S
Cas No.	117-89-5
Smiles	CN1CCN(CCCN2C3=C(SC4=C2C=C(C=C4)C(F)(F)F)C=CC=C3)CC1
Relative Density.	1.2060 g/cm3 (Estimated)

Storage & Solubility Information

Storage

keep away from moisture,store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 242 mg/mL (593.87 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4540 mL	12.2699 mL	24.5399 mL	122.6994 mL
5 mM	0.4908 mL	2.4540 mL	4.9080 mL	24.5399 mL
10 mM	0.2454 mL	1.2270 mL	2.4540 mL	12.2699 mL
20 mM	0.1227 mL	0.6135 mL	1.2270 mL	6.1350 mL
50 mM	0.0491 mL	0.2454 mL	0.4908 mL	2.4540 mL
100 mM	0.0245 mL	0.1227 mL	0.2454 mL	1.2270 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc