Powder: -20°C for 3 years | In solvent: -80°C for 2 years
Atazanavir sulfate is an azapeptide and HIV-PROTEASE INHIBITOR that is used in the treatment of HIV INFECTIONS and AIDS in combination with other ANTI-HIV AGENTS.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 41.00 | |
10 mg | In stock | $ 64.00 | |
25 mg | In stock | $ 98.00 | |
50 mg | In stock | $ 126.00 | |
100 mg | In stock | $ 216.00 | |
200 mg | In stock | $ 324.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 64.00 |
Description | Atazanavir sulfate is an azapeptide and HIV-PROTEASE INHIBITOR that is used in the treatment of HIV INFECTIONS and AIDS in combination with other ANTI-HIV AGENTS. |
Targets&IC50 | HIV protease:2.66 nM(Ki) |
Kinase Assay | Protease assays: To determine the inhibition constants (Ki) for each Prt inhibitor, purified HIV-1 RF wild-type Prt (2.5 nM) is incubated at 37 ℃ with 1 μM to 15 μM fluorogenic substrate in reaction buffer (1 M NaCl, 1 mM EDTA, 0.1 M sodium acetate [pH 5.5], 0.1% polyethylene glycol 8000) in the presence or absence of Atazanavir. Cleavage of the substrate is quantified by measuring an increase in fluorescent emission at 490 nM after excitation at 340 nM using a Cytofluor 4000. Reactions are carried out using 1.36 μM, 1.66 μM, 2.1 μM, 3.0 μM, 5.0 μM, or 15 μM substrate in the presence of five concentrations of Atazanavir (1.25 nM to 25 nM). Substrate cleavage is monitored at 5-min intervals for 30 min. Cleavage rates are then determined for each sample at early time points in the reaction, and Ki values are determined from the slopes of the resulting Michaelis-Menten plots. |
Cell Research | To determine cytotoxicity, host cells are incubated in the presence of serially diluted Atazanavir for 6 days and cell viability is quantitated using an XTT[2,3-bis(2-methoxy-4-nitro-5-sulfophenyl-2H-tetrazolium-5-carboxanilide] assay to calculate the 50% cytotoxic concentrations (CC50s). To assess the effect of human serum proteins on antiviral activity, the 10% fetal calf serum normally used for assays is replaced with 40% adult human serum or 1 mg of α1-acid glycoprotein/mL.(Only for Reference) |
Synonyms | BMS-232632 sulfate, BMS-232632 |
Molecular Weight | 802.93 |
Formula | C38H52N6O7·H2SO4 |
CAS No. | 229975-97-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
Ethanol: <1 mg/mL
DMSO: 96 mg/mL (119.6 mM)
H2O: <1 mg/mL
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Atazanavir sulfate 229975-97-7 Membrane transporter/Ion channel Metabolism Microbiology/Virology Neuroscience Proteases/Proteasome SARS-CoV P450 HIV Protease P-gp CYPs Human immunodeficiency virus CD243 Inhibitor ABCB1 Cytochrome P450 BMS232632 Multidrug resistance protein 1 BMS 232632 Cluster of differentiation 243 SARS coronavirus Atazanavir Pgp HIV BMS-232632 sulfate inhibit P-glycoprotein MDR1 BMS-232632 inhibitor