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Atazanavir sulfate

Catalog No. T0100 CAS 229975-97-7

Synonyms: BMS-232632 sulfate, BMS-232632

Atazanavir sulfate is an azapeptide and HIV-PROTEASE INHIBITOR that is used in the treatment of HIV INFECTIONS and AIDS in combination with other ANTI-HIV AGENTS.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Atazanavir sulfate, CAS 229975-97-7

Pack Size	Availability	Price/USD
5 mg	In stock	$ 41.00
10 mg	In stock	$ 64.00
25 mg	In stock	$ 98.00
50 mg	In stock	$ 126.00
100 mg	In stock	$ 216.00
200 mg	In stock	$ 324.00
1 mL * 10 mM (in DMSO)	In stock	$ 64.00

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Purity: 99.67%

Purity: 99.31%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Atazanavir sulfate is an azapeptide and HIV-PROTEASE INHIBITOR that is used in the treatment of HIV INFECTIONS and AIDS in combination with other ANTI-HIV AGENTS.
Targets&IC50	HIV protease:2.66 nM(Ki)
Kinase Assay	Protease assays: To determine the inhibition constants (Ki) for each Prt inhibitor, purified HIV-1 RF wild-type Prt (2.5 nM) is incubated at 37 ℃ with 1 μM to 15 μM fluorogenic substrate in reaction buffer (1 M NaCl, 1 mM EDTA, 0.1 M sodium acetate [pH 5.5], 0.1% polyethylene glycol 8000) in the presence or absence of Atazanavir. Cleavage of the substrate is quantified by measuring an increase in fluorescent emission at 490 nM after excitation at 340 nM using a Cytofluor 4000. Reactions are carried out using 1.36 μM, 1.66 μM, 2.1 μM, 3.0 μM, 5.0 μM, or 15 μM substrate in the presence of five concentrations of Atazanavir (1.25 nM to 25 nM). Substrate cleavage is monitored at 5-min intervals for 30 min. Cleavage rates are then determined for each sample at early time points in the reaction, and Ki values are determined from the slopes of the resulting Michaelis-Menten plots.
Cell Research	To determine cytotoxicity, host cells are incubated in the presence of serially diluted Atazanavir for 6 days and cell viability is quantitated using an XTT[2,3-bis(2-methoxy-4-nitro-5-sulfophenyl-2H-tetrazolium-5-carboxanilide] assay to calculate the 50% cytotoxic concentrations (CC50s). To assess the effect of human serum proteins on antiviral activity, the 10% fetal calf serum normally used for assays is replaced with 40% adult human serum or 1 mg of α1-acid glycoprotein/mL.(Only for Reference)

Synonyms	BMS-232632 sulfate, BMS-232632
Molecular Weight	802.93
Formula	C38H52N6O7·H2SO4
CAS No.	229975-97-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

Ethanol: <1 mg/mL

DMSO: 96 mg/mL (119.6 mM)

H2O: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Robinson BS, et al. Antimicrob Agents Chemother, 2000, 44(8), 2093-2099. 2. Zhang D, et al. Drug Metab Dispos, 2005, 33(11), 1729-1739. 3. Pyrko P, et al. Cancer Res, 2007, 67(22), 10920-10928. 4. Parker RA, et al. Mol Pharmacol, 2005, 67(6), 1909-1919. 5. Perloff ES, et al. Drug Metab Dispos, 2005, 33(6), 764-770.

Related compound libraries

This product is contained In the following compound libraries：

CNS-Penetrant Compound Library Anti-Cancer Clinical Compound Library Approved Drug Library Anti-Infection Compound Library Target-Focused Phenotypic Screening Library Clinical Compound Library Protease Inhibitor Library Anti-Cancer Drug Library Inhibitor Library Anti-Metabolism Disease Compound Library

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Related compounds with same targets

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Keywords

Atazanavir sulfate 229975-97-7 Membrane transporter/Ion channel Metabolism Microbiology/Virology Neuroscience Proteases/Proteasome SARS-CoV P450 HIV Protease P-gp CYPs Human immunodeficiency virus CD243 Inhibitor ABCB1 Cytochrome P450 BMS232632 Multidrug resistance protein 1 BMS 232632 Cluster of differentiation 243 SARS coronavirus Atazanavir Pgp HIV BMS-232632 sulfate inhibit P-glycoprotein MDR1 BMS-232632 inhibitor

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