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Rhodamine 6G

Catalog No. T16744 CAS 989-38-8

Synonyms: Basic Red 1

Rhodamine 6G (Basic Red 1) is a rhodamine analog useful in Pgp efflux assays. It can be widely used in characterizing the kinetics of MRP1- mediated efflux as a laser dye and potential mitochondrial probe.

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Rhodamine 6G, CAS 989-38-8

Pack Size	Availability	Price/USD
100 mg	In stock	$ 30.00
500 mg	In stock	$ 61.00
1 g	In stock	$ 78.00
5 g	In stock	$ 118.00
10 g	In stock	$ 173.00
1 mL * 10 mM (in DMSO)	In stock	$ 53.00

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Purity: 99.18%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Rhodamine 6G (Basic Red 1) is a rhodamine analog useful in Pgp efflux assays. It can be widely used in characterizing the kinetics of MRP1- mediated efflux as a laser dye and potential mitochondrial probe.
In vitro	Rhodamine 6G, also known as Rhodamine 590, is widely used as a lasing medium and as a fluorescence tracer. Rhodamine 6G is a fluorescent dye capable of penetrating a living cell. Upon entering the cell, Rhodamine 6G binds to the inner membranes of mitochondria. Based on these observations, it has been proposed that Rhodamine dyes may be used for producing fluorescent images of mitochondria with low background noise and high resolution. Extremely low concentrations of Rhodamine 6G appear to selectively destroy malignant cells in culture, sparing the normal cell populations[2].
In vivo	Compared to their untreated counterparts, Melanoma-transplanted mice receiving Rhodamine 6G demonstrate prolonged survival, inhibited tumor growth, improved clinical parameters and metastases count. It is possible to monitor changes in the interactions between leukocytes and the endothelium by determining the numbers of rolling and adhering leukocytes as well as the total flux of these cells[3]. The Rhodamine-6G enters the circulatory system and labels leukocytes. Twice-a-week 10-6M Rhodamine 6G regimen yield the most prominent results[2].

Synonyms	Basic Red 1
Molecular Weight	479.01
Formula	C28H31ClN2O3
CAS No.	989-38-8

Storage

keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 83.3 mg/mL (173.97 mM), Sonication is recommended.

DMSO: 7.5 mg/mL (15.66 mM), Sonication is recommended.

References and Literature

1. Zehentbauer FM, et al. Fluorescence spectroscopy of Rhodamine 6G: concentration and solvent effects. Spectrochim Acta A Mol Biomol Spectrosc. 2014;121:147-51. 2. Kutushov M, et al. Low concentrations of Rhodamine 6G selectively destroy tumor cells and improve survival of melanoma transplanted mice. Neoplasma. 2013;60(3):262-73. 3. Jain RK, et al. Measuring leukocyte-endothelial interactions in mice. Cold Spring Harb Protoc. 2013 Jun 1;2013(6):561-3.

Related compound libraries

This product is contained In the following compound libraries：

Human Metabolite Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Rhodamine 6G 989-38-8 Others Basic Red 1 Basic Red-1 Basic Red1 inhibit Inhibitor inhibitor

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