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Polyoxyethylene stearate

Polyoxyethylene stearate
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Purity:polymer
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Polyoxyethylene stearate

Catalog No. T16561Cas No. 9004-99-3
Polyoxyethylene stearate (POES) is an agent of non-ionic emulsifying.
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Pack SizePrice/USDAvailabilityQuantity
500 mg$30In Stock
1 g$42In Stock
5 g$75In Stock
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Product Introduction

Bioactivity
Description
Polyoxyethylene stearate (POES) is an agent of non-ionic emulsifying.
In vitro
Polyoxyethylene stearate modulates P-gp ATPase activity in a concentration-dependent manner, reducing P-gp mediated efflux, notably enhancing the efficacy of substances like vinblastine sulfate by limiting their expulsion from cells. This compound is also recommended to augment the radiolabelled 7H12 Middlebrook TB media, significantly promoting mycobacterial growth in the BACTEC rapid culture system. Its effectiveness extends across various mycobacterial species beyond M. tuberculosis. Specifically, at concentrations of 100 or 150 μg/mL, polyoxyethylene 40 stearate substantially increases the cytotoxicity of vinblastine to K562/ADR cells. Moreover, polyoxyethylene (50) stearate markedly boosts mycobacterial growth rates and decreases detection times in cultures, illustrating its broad potential in enhancing antimicrobial and chemotherapeutic treatments.
In vivo
In the combination of polyoxyethylene 40 stearate and vinblastine, there is a significant reduction in both the average tumor volume and weight compared to the vinblastine group alone. The tumor growth inhibition rate markedly increases from 0.06 (vinblastine group) to 0.84 (vinblastine+polyoxyethylene 40 stearate group). Furthermore, polyoxyethylene stearate shows potential as a pharmaceutical excipient to enhance the oral bioavailability of drugs that are substrates for P-glycoprotein (P-gp) and certain cytochrome P450 (CYP) isoforms [2][3].
AliasPOES
Chemical Properties
FormulaC20H40O3
Cas No.9004-99-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 45 mg/mL (136.97 mM)

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For example, your dosage is 10 mg/kg,each TargetMol | Animal experiments animal weighs 20 g, and the dosage volume is 100 μL. A total of TargetMol | Animal experiments 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL.
Mother liquor preparation method: 2 mg of drug dissolved in 50 μLDMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μLDMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μLTween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify.
1 Enter information below:
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