keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Verapamil (CP-16533-1) is a calcium channel blocker and an orally active and effective inhibitor of P-gp. Verapamil inhibits CYP3A4 and can be used in studies about the treatment of high blood pressure, heart arrhythmias, and angina research.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | In stock | $ 30.00 | |
25 mg | In stock | $ 47.00 | |
50 mg | In stock | $ 67.00 | |
100 mg | In stock | $ 97.00 | |
200 mg | In stock | $ 146.00 | |
500 mg | In stock | $ 243.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | Verapamil (CP-16533-1) is a calcium channel blocker and an orally active and effective inhibitor of P-gp. Verapamil inhibits CYP3A4 and can be used in studies about the treatment of high blood pressure, heart arrhythmias, and angina research. |
In vitro | Verapamil inhibits the EverFluor FL Verapamil (EFV) uptake by TR-iBRB2 cells with an IC50 of 98.0 μM in a concentration-dependent manner[1]. |
In vivo | Verapamil (1 mg/kg;i.v.) significantly decreases the incidence of ventricular arrhythmias including premature ventricular contractions (PVC), ventricular tachycardia (VT) and ventricular fibrillation (VF) for 45-min coronary artery occlusion. Total arrhythmia scores are significantly increased when the heart is subjected to ischemia. Verapamil (1 mg/kg) significantly prevents the enhancement of total arrhythmia scores induced by ischemia[3]. Verapamil(oral) is useful for the prophylaxis of atrioventricular reentry tachycardia, and also in modulating the atrioventricular nodal response in atrial fibrillation[4]. |
Synonyms | NSC 135784, NSC-135784, CP-16533-1, (±)-Verapamil |
Molecular Weight | 454.6 |
Formula | C27H38N2O4 |
CAS No. | 52-53-9 |
keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 95 mg/mL (208.97 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Verapamil 52-53-9 Membrane transporter/Ion channel Metabolism Neuroscience P-gp Calcium Channel P450 inhibit NSC 135784 Pgp antiarrhythmic CYP3A4 Cytochrome P450 Palbociclib CYPs pressure ABCB1 angina Multidrug resistance protein 1 Ca2+ channels NSC-135784 lysosomotropic MDR1 Ca channels CP-16533-1 Cluster of differentiation 243 high NSC135784 Inhibitor P-glycoprotein CD243 (±)-Verapamil blood inhibitor