Shopping Cart

Your shopping cart is currently empty

Deoxynivalenol

Name: Deoxynivalenol
Brand: TargetMol
SKU: T15097
Price: 89 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: Vomitoxin, 4-Deoxynivalenol) Copy Product Info

😃Good

Hot

Synonyms: Vomitoxin, 4-Deoxynivalenol

Catalog No. T15097 Copy Product Info

Purity: 99.84%

😃Good

Hot

Deoxynivalenol (Vomitoxin) is an orally active mycotoxin belonging to the trichothecenes family, which traverses the intestinal mucosa via the paracellular pathway without being affected by P-gp/MRP, used for research on gastrointestinal inflammation such as diarrhea and vomiting.

Cas No. 51481-10-8

Pack Size	Price	USA Stock	Global Stock
1 mg	$89	In Stock	In Stock
5 mg	$328	In Stock	In Stock
10 mg	$543	In Stock	In Stock
25 mg	$896	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

Add to Cart

Add to Quotation

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

Batch Information

Select Batch

Purity:99.84%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Deoxynivalenol (Vomitoxin) is an orally active mycotoxin belonging to the trichothecenes family, which traverses the intestinal mucosa via the paracellular pathway without being affected by P-gp/MRP, used for research on gastrointestinal inflammation such as diarrhea and vomiting.
Targets & IC50	COLO 201 cells:86 μM, IPEC-J2 cells:25.93 ± 5.13 μM (72 h), IPEC-J2 cells:44.83 ± 6.14 μM (48 h), K562 cells:1010 nM (EC50)
In vitro	Methods: IPEC-J2 cells were incubated with 0–12 μmol/L Deoxynivalenol (DON) for 24 hours. Cell viability was measured by CCK-8 assay, monolayer permeability was assessed by FITC-dextran method, cell apoptosis was observed by TUNEL staining, and the expression and distribution of ZO-1 and F-actin were detected by immunofluorescence. Results: DON concentration-dependently reduced cell viability, increased monolayer permeability, induced cell apoptosis, and disrupted tight junction structures associated with ZO-1 and F-actin. [1] Methods: IPEC-J2 cells were incubated with 100 ng/mL Deoxynivalenol (DON) for 24–72 hours. Cell viability and proliferation were detected by MTT and EdU assays, and protein expression was determined by Western blotting and immunofluorescence. Results: DON inhibited cell viability and proliferation, downregulated p-mTOR, p-S6K1, and p-S6 expression, and upregulated TSC2 expression, indicating that DON affects cellular function through the TSC2/mTORC1 pathway.[2]
In vivo	Methods: To investigate the developmental toxicity of Deoxynivalenol, pregnant rats were administered Deoxynivalenol (0–5 mg/kg) by gavage once daily for 14 consecutive days, with observation of salivation symptoms and fetal skeletal development. Results: Deoxynivalenol increased the number of pregnant rats with excessive salivation in a dose-related manner; at a dose of 5 mg/kg, it caused abnormal sternal development in rat fetuses. [3] Methods: Prepubertal (21-day-old) and adult (65-day-old) female Swiss mice were selected and fed diets containing 10 mg/kg Deoxynivalenol (DON) for 15 or 28 days, respectively; the control group was fed mycotoxin-free diets. Results: Deoxynivalenol (DON) induced ovarian tissue damage, altered serum follicle-stimulating hormone levels, and triggered age-dependent inflammatory responses and oxidative stress. [4]
Synonyms	Vomitoxin, 4-Deoxynivalenol

Chemical Properties

Molecular Weight	296.32
Formula	C₁₅H₂₀O₆
Cas No.	51481-10-8
Smiles	CC1=C[C@H]2O[C@@H]3[C@H](O)C[C@@](C)([C@]33CO3)[C@@]2(CO)[C@H](O)C1=O
Relative Density.	1.48g/cm3

Storage & Solubility Information

Storage

Store at low temperature,Keep away from moisture,Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 260 mg/mL (877.43 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (16.87 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3747 mL	16.8737 mL	33.7473 mL	168.7365 mL
5 mM	0.6749 mL	3.3747 mL	6.7495 mL	33.7473 mL
10 mM	0.3375 mL	1.6874 mL	3.3747 mL	16.8737 mL
20 mM	0.1687 mL	0.8437 mL	1.6874 mL	8.4368 mL
50 mM	0.0675 mL	0.3375 mL	0.6749 mL	3.3747 mL
100 mM	0.0337 mL	0.1687 mL	0.3375 mL	1.6874 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Keywords

Deoxynivalenol

Related Tags: Deoxynivalenol chemical structure | Deoxynivalenol in vivo | Deoxynivalenol in vitro | Deoxynivalenol formula | Deoxynivalenol molecular weight