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Solamargine

Catalog No. T4034   CAS 20311-51-7
Synonyms: Solamargin, δ-Solanigrine

Solamargine (δ-Solanigrine) is a major steroidal alkaloid glycoside extracted from a traditional Chinese medicine herb, Solanum nigrum L. (SNL); has been shown to inhibit growth and induce apoptosis of various cancer cells.

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Solamargine Chemical Structure
Solamargine, CAS 20311-51-7
Pack Size Availability Price/USD Quantity
1 mg In stock $ 54.00
5 mg In stock $ 117.00
10 mg In stock $ 177.00
25 mg In stock $ 363.00
50 mg In stock $ 562.00
100 mg In stock $ 790.00
1 mL * 10 mM (in DMSO) In stock $ 169.00
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Purity: 99.76%
Purity: 99.17%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Solamargine (δ-Solanigrine) is a major steroidal alkaloid glycoside extracted from a traditional Chinese medicine herb, Solanum nigrum L. (SNL); has been shown to inhibit growth and induce apoptosis of various cancer cells.
In vitro Solamargine concentration-dependently reduced HepG2 cell viability. Solamargine (7.5 μM) reduced cell viability by less than 20% in HepG2 cells. Solamargine (highest dose) decreased cell invasion and migration by more than 72% and 70% in HepG2 cells, respectively. Solamargine reduced function and expression of MMP-2/9 proteins. Solamargine time-dependently increased phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK) in a fashion.
Source
Synonyms Solamargin, δ-Solanigrine
Molecular Weight 868.06
Formula C45H73NO15
CAS No. 20311-51-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 91 mg/mL(104.8 mM)

TargetMolReferences and Literature

1. Sani IK., et al. Solamargine inhibits migration and invasion of human hepatocellular carcinoma cells through down-regulation of matrix metalloproteiN/Ases 2 and 9 expression and activity. Toxicol In Vitro. 2015 Aug;29(5):893-900. 2. Zhou Y, et al. Targeting sigN/Al transducer and activator of transcription 3 contributes to the solamargine-inhibited growth and -induced apoptosis of human lung cancer cells. Tumour Biol. 2014 Aug;35(8):8169-78. 3. Ding X, et al. Induction of apoptosis in human hepatoma SMMC-7721 cells by solamargine from Solanum nigrum L. J Ethnopharmacol. 2012 Jan 31;139(2):599-604.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Reprogramming Compound Library Anti-Fibrosis Compound Library Bioactive Lipid Compound Library Human Metabolite Library MAPK Inhibitor Library JAK-STAT Compound Library Neural Regeneration Compound Library Anti-Lung Cancer Compound Library Kinase Inhibitor Library

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Keywords

Solamargine 20311-51-7 Apoptosis JAK/STAT signaling MAPK Membrane transporter/Ion channel Neuroscience Stem Cells p38 MAPK P-gp STAT Inhibitor cytotoxicity cells Cluster of differentiation 243 MDR1 Pgp Solamargin P-glycoprotein ABCB1 inhibit cancer gastric delta-Solanigrine δ-Solanigrine Multidrug resistance protein 1 CD243 HepG2 inhibitor

 

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