Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Hypophyllanthin and phyllanthin have antitumour effects against Ehrlich Ascites Carcinoma in mice.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 98.00 | |
5 mg | In stock | $ 259.00 | |
10 mg | In stock | $ 387.00 | |
25 mg | In stock | $ 637.00 | |
50 mg | In stock | Inquiry | |
1 mL * 10 mM (in DMSO) | In stock | $ 296.00 |
Description | Hypophyllanthin and phyllanthin have antitumour effects against Ehrlich Ascites Carcinoma in mice. |
In vitro | The activity of P-gp and MRP2 was determined in the uptake assays by monitoring the intracellular accumulation of their specific substrates (calcein acetoxymethyl ester and 5(6)-carboxy-2',7'-dichlorofluorescein diacetate, respectively) with fluorescence spectroscopy. Hypophyllanthin and phyllanthin inhibited P-gp function with comparable potencies, but neither compound affected MRP2 activity. When the lignans were washed out before addition of substrate, the inhibitory action of both compounds against P-gp function was lost. These results suggested the reversibility of the inhibition. Moreover, prolonged exposure of the Caco-2 cells to both lignans (up to 7 days) had no effect on P-gp function[1] |
Source |
Molecular Weight | 430.49 |
Formula | C24H30O7 |
CAS No. | 33676-00-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (232.29 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Hypophyllanthin 33676-00-5 Membrane transporter/Ion channel Metabolism Neuroscience P-gp Calcium Channel Potassium Channel Inhibitor CD243 Pgp inhibit ABCB1 P-glycoprotein Cluster of differentiation 243 Multidrug resistance protein 1 MDR1 inhibitor