Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Encequidar mesylate (HM30181A mesylate) is a competitive P-glycoprotein inhibitor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 34.00 | |
5 mg | In stock | $ 72.00 | |
10 mg | In stock | $ 98.00 | |
25 mg | In stock | $ 181.00 | |
50 mg | In stock | $ 315.00 | |
100 mg | In stock | $ 495.00 | |
500 mg | In stock | $ 1,120.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 86.00 |
Description | Encequidar mesylate (HM30181A mesylate) is a competitive P-glycoprotein inhibitor. |
In vitro | Treatment of 0.1 or 1 nM Encequidar lead to 20 and 42% inhibition of survival at the 100 nM and 1000 nM NSC 125973 treatment, respectively [2]. |
In vivo | The plasma concentrations of Encequidar are higher for the simultaneous administration with the microcapsule than with the powder; providing significant differences from 1 to 2 h. The microcapsule has about a 1.7-fold faster Tmax and a 1.6-fold higher AUC value compared with the powder (2.5±0.6 vs. 4.3±0.9 h; 107.7±20.1 vs. 64.3±18.0 h ng/mL). The faster and overall improved absorption of Encequidar in microcapsule form might be due to the remarkable enhancement of the aqueous solubility and dissolution resulting from its crystalline conversion to the amorphous form and particle size reduction [1]. |
Synonyms | HM30181 mesylate, HM30181A mesylate |
Molecular Weight | 784.83 |
Formula | C39H40N6O10S |
CAS No. | 849675-87-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (31.85 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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Encequidar mesylate 849675-87-2 Membrane transporter/Ion channel Neuroscience P-gp HM30181A HM 30181 Mesylate HM30181 Mesylate HM 30181 HM30181 mesylate Encequidar Mesylate HM30181 MDR1 ABCB1 HM-30181 Mesylate inhibit CD243 P-glycoprotein Cluster of differentiation 243 HM-30181 Inhibitor HM30181A Mesylate Encequidar Pgp HM30181A mesylate Multidrug resistance protein 1 inhibitor