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Glibenclamide

Catalog No. T1634 CAS 10238-21-8

Synonyms: Glyburide

Glyburide is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.

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Glibenclamide, CAS 10238-21-8

Pack Size	Availability	Price/USD
500 mg	In stock	$ 50.00
1 g	In stock	$ 53.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.77%

Purity: 99.39%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Glyburide is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.

Synonyms	Glyburide
Molecular Weight	494.0
Formula	C23H28ClN3O5S
CAS No.	10238-21-8

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 99 mg/mL (200.4 mM)

H2O: <1 mg/mL

Ethanol: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Winquist RJ, et al. J Pharmacol Exp Ther,1989, 248(1), 149-156. 2. Nieland TJ, et al. J Lipid Res,2004, 45(7), 1256-1265. 3. Brady PA, et al. Eur J Pharmacol,1996, 308(3), 343-349. 4. Meisheri KD, et al. J Vasc Res,1993, 30(1), 2-12. 5. Clark MA, et al. J Pharmacol Exp Ther,1993, 265(2), 933-937. 6. Juarez-Mercado K E, Prieto-Martinez F D, Sanchez-Cruz N, et al. DNA Methyltransferase Inhibitors with Novel Chemical Scaffolds[J]. bioRxiv. 2020 7. Chen F, Xu Y, Wang J, et al. Relaxation Effect of Patchouli Alcohol in Rat Corpus Cavernous and Its Underlying Mechanisms[J]. Evidence-Based Complementary and Alternative Medicine. 2020, 2020. 8. Capoci I R G, Faria D R, Sakita K M, et al. Repurposing approach identifies new treatment options for invasive fungal disease[J]. Bioorganic chemistry. 2019 Mar;84:87-97. 9. Juárez-Mercado K E, Prieto-Martínez F D, Sánchez-Cruz N, et al. Expanding the Structural Diversity of DNA Methyltransferase Inhibitors[J]. Pharmaceuticals. 2021, 14(1): 17.

Citations

1. Juárez-Mercado K E, Prieto-Martínez F D, Sánchez-Cruz N, et al. Expanding the Structural Diversity of DNA Methyltransferase Inhibitors. Pharmaceuticals. 2021, 14(1): 17. 2. Capoci I R G, Faria D R, Sakita K M, et al. Repurposing approach identifies new treatment options for invasive fungal disease. Bioorganic Chemistry. 2019 Mar;84:87-97 3. Chen F, Xu Y, Wang J, et al. Relaxation Effect of Patchouli Alcohol in Rat Corpus Cavernous and Its Underlying Mechanisms. Evidence-Based Complementary and Alternative Medicine. 2020.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Approved Drug Library Clinical Compound Library Pediatric Drug Library Metabolism Compound Library Ion Channel Inhibitor Library NO PAINS Compound Library Anti-Diabetic Compound Library Anti-Cancer Approved Drug Library Target-Focused Phenotypic Screening Library

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Dose Conversion

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Glibenclamide 10238-21-8 Autophagy Membrane transporter/Ion channel Metabolism Neuroscience P-gp Mitochondrial Metabolism CFTR Potassium Channel Cystic fibrosis transmembrane conductance regulator Inhibitor Multidrug resistance protein 1 fibrosis regulator bioenergetics Cluster of differentiation 243 inhibit mitochondrial cystic KcsA conductance MDR1 adipocytes Pgp Glyburide P-glycoprotein CD243 ABCB1 SUR1 obesity transmembrane ATP-sensitive diabetes inhibitor

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