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Glibenclamide

Catalog No. T1634   CAS 10238-21-8
Synonyms: Glyburide

Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.

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Glibenclamide Chemical Structure
Glibenclamide, CAS 10238-21-8
Pack Size Availability Price/USD Quantity
500 mg In stock $ 45.00
1 g In stock $ 53.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 99.77%
Purity: 99.39%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.
Synonyms Glyburide
Molecular Weight 494
Formula C23H28ClN3O5S
CAS No. 10238-21-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 99 mg/mL (200.4 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

TargetMolReferences and Literature

1. Winquist RJ, et al. J Pharmacol Exp Ther,1989, 248(1), 149-156. 2. Nieland TJ, et al. J Lipid Res,2004, 45(7), 1256-1265. 3. Brady PA, et al. Eur J Pharmacol,1996, 308(3), 343-349. 4. Meisheri KD, et al. J Vasc Res,1993, 30(1), 2-12. 5. Clark MA, et al. J Pharmacol Exp Ther,1993, 265(2), 933-937. 6. Juarez-Mercado K E, Prieto-Martinez F D, Sanchez-Cruz N, et al. DNA Methyltransferase Inhibitors with Novel Chemical Scaffolds[J]. bioRxiv. 2020 7. Chen F, Xu Y, Wang J, et al. Relaxation Effect of Patchouli Alcohol in Rat Corpus Cavernous and Its Underlying Mechanisms[J]. Evidence-Based Complementary and Alternative Medicine. 2020, 2020. 8. Capoci I R G, Faria D R, Sakita K M, et al. Repurposing approach identifies new treatment options for invasive fungal disease[J]. Bioorganic chemistry. 2019 Mar;84:87-97. 9. Juárez-Mercado K E, Prieto-Martínez F D, Sánchez-Cruz N, et al. Expanding the Structural Diversity of DNA Methyltransferase Inhibitors[J]. Pharmaceuticals. 2021, 14(1): 17.

TargetMolCitations

1. Juárez-Mercado K E, Prieto-Martínez F D, Sánchez-Cruz N, et al. Expanding the Structural Diversity of DNA Methyltransferase Inhibitors. Pharmaceuticals. 2021, 14(1): 17. 2. Capoci I R G, Faria D R, Sakita K M, et al. Repurposing approach identifies new treatment options for invasive fungal disease. Bioorganic Chemistry. 2019 Mar;84:87-97 3. Chen F, Xu Y, Wang J, et al. Relaxation Effect of Patchouli Alcohol in Rat Corpus Cavernous and Its Underlying Mechanisms. Evidence-Based Complementary and Alternative Medicine. 2020.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Drug Repurposing Compound Library FDA-Approved Drug Library Anti-Diabetic Compound Library Anti-Fibrosis Compound Library Neuronal Signaling Compound Library NO PAINS Compound Library Orally Active Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Glibenclamide 10238-21-8 Autophagy Membrane transporter/Ion channel Metabolism Neuroscience P-gp CFTR Mitochondrial Metabolism Potassium Channel Cystic fibrosis transmembrane conductance regulator Inhibitor Multidrug resistance protein 1 fibrosis regulator bioenergetics Cluster of differentiation 243 inhibit mitochondrial cystic KcsA Glyburide conductance MDR1 adipocytes Pgp P-glycoprotein CD243 ABCB1 SUR1 obesity transmembrane ATP-sensitive diabetes inhibitor

 

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