Search Result

Search Results for " tnf-alpha "

Targets

Compounds

Natural Products

Recombinant Proteins

Libraries

Cat No.	Product Name	Synonyms	Targets
T77494	TNF-α-IN-9		TNF
	TNF-α-IN-9 is an NDM-1 inhibitor-3 analog and is a TNF-α inhibitor.TNF-α-IN-9 shows low inhibitory activity.		TNF
T4637	R-7050	TNF-α Antagonist III	TNF
	R-7050 (TNF-α Antagonist III), a tumor necrosis factor receptor (TNFR) antagonist, exhibits heightened selectivity for TNFα.		TNF
T19584L	TNF-α (31-45), human acetate	TNF-α (31-45), human acetate(144796-71-4 free base)	Others
	TNF-α (31-45), human acetate is a peptide of tumor necrosis factor-α.		Others
T78272	Anti-Mouse TNF alpha Antibody (TN3-19.12)
	Anti-Mouse TNF alpha Antibody is a rat-derived IgG inhibitor targeting mouse TNF alpha.
TP1626	TNF-α (46-65), human
	Human TNF alpha (46-65) peptide.
T40321	TNF-α-IN-6
	TNF-α-IN-6 is an orally efficacious allosteric inhibitor of TNFα ( K D = 6.8 nM).
T36127	TNF-α Antagonist
	TNF-α antagonist is an exocyclic peptide that mimics the critical TNF-α recognition loop on TNF receptor I complex and, thus, prevents ligand interaction with the receptor. By blocking the TNF receptor ligand contact sit...
T13175	TNF-α-IN-1		TNF
	TNF-α-IN-1 is a TNF-α inhibitor.		TNF
T36097	TNF-α-IN-2
	TNF-α-IN-2 is a highly potent and orally bioavailable inhibitor of tumor necrosis factor alpha (TNFα), exhibiting an IC50 of 25 nM in the HTRF assay. It exerts its inhibitory effects by inducing conformational changes in...
T19584	TNF-α (31-45), human		Others
	TNF-α (31-45), human is a peptide of tumor necrosis factor-α.		Others
TP1537	TNF-α (10-36), human
	TNF-α (10-36), human is a potent pro-inflammatory cytokine involved in the acute phase stress response.
TP1479	TNF-α (10-36), human (TFA) (144796-70-3 free base)	TNF-α (10-36), human (TFA)
	TNF-α (10-36), human (TFA) is a peptide of human TNF-α.
T4403	AX-024 hydrochloride	AX-024 HCl	IL Receptor , TNF , COX , IFNAR , Interleukin
	AX-024 hydrochloride (AX-024 HCl) is an cytokine release inhibitor which can strongly inhibit the production of interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), interferon-γ (IFN-γ), IL-10 and IL-17A.		IL Receptor , TNF , COX , IFNAR , Interleukin
T78434	Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human) TFA
	Mca-(endo-1α-Dap(Dnp))-TNF-α(-5 to +6) amide (human) TFA is a peptide that functions as a fluorescence resonance energy transfer (FRET)-based substrate, with its activity determined by the change in fluorescence intensit...
T81838	Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human)
	Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human) is a peptide utilized as a fluorescence resonance energy transfer (FRET) based substrate for proteolytic activity assays, wherein the cleavage-induced change in f...
TP1636	TNF-α (31-45), human TFA (144796-71-4 free base)	TNF-α (31-45), human TFA
	TNF-α (31-45), human (TFA) is a peptide of tumor necrosis factor-α.
TP1669	TNF-α (46-65), human TFA (144796-72-5 free base)	TNF-α (46-65), human TFA
	TNF-α (46-65), human (TFA) is a peptide of human TNF-α.
T9901	Adalimumab		TNF
	Adalimumab (anti-TNF-alpha) is the first fully human recombinant IgG1 monoclonal antibody that specifically targets human TNF-alpha.		TNF
TP1615L	IKKγ NBD Inhibitory Peptide acetate	IKKγ NBD Inhibitory Peptide acetate(372146-18-4 free base)	NF-κB
	IKKγ NBD Inhibitory Peptide acetate is a NEMO-binding domain peptide (NBD peptide) acetate corresponding to the NEMO amino-terminal alpha-helical region. IKKγ NBD Inhibitory Peptide acetate is shown to block TNF-alpha-in...		NF-κB
T4412	Roquinimex	Linomide,LS2616,FCF89,ABR212616	TNF
	Roquinimex (FCF89) (Linomide) is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity; inhibits angiogenesis and reduces the secretion of TNF alpha.		TNF
T10865	Cot inhibitor-1		TNF , MAPK
	Cot inhibitor-1 is a selective inhibitor of Cot protein kinase (also known as Tpl2 or MAP3K8) (IC50 at 28 nM). Cot inhibitor-1 inhibited TNF-alpha production in human whole blood with IC50 of 5.7 nM. Cot is involved in a...		TNF , MAPK
T24816	SP-100030	SP100030,SP 100030	NF-κB
	SP-100030 is a dual inhibitor of NF-κB and activator protein-1 (AP-1), demonstrating potent inhibition with IC50 values of 50 nM for both. It effectively reduces the production of IL-2, IL-8, and TNF-alpha in Jurkat and ...		NF-κB
T7091	N-Formyl-Met-Leu-Phe	fMLP,N-Formyl-MLF	TNF
	N-Formyl-Met-Leu-Phe (N-Formyl-MLF) (fMLF) is a synthetic peptide that acts as an agonist at formyl peptide receptors (FPR; Ki = 0.8 pM).		TNF
T1562	Rebamipide	Proamipide,OPC12759	Free radical scavengers , COX , Prostaglandin Receptor
	Rebamipide (OPC12759) is a quinolinone derivative with anti-ulcer and anti-inflammatory activities. Rebamipide induces cyclooxygenase 2 (COX2) synthesis which results in an increase in endogenous prostaglandin synthesis ...		Free radical scavengers , COX , Prostaglandin Receptor
T77064	Licaminlimab
	Licaminlimab (OCS-02) is a single-chain anti-TNF alpha antibody fragment that targets TNF alpha, an inflammatory cytokine produced by macrophages and monocytes during inflammation [1].
T26624	AN0128	AN 0128,CRM-0005,CRM0005,ONT0001,AN-0128,ONT-0001
	AN 0128 is a tumour necrosis factor alpha (TNF-α) inhibitor.
T69594	IM-491
	IM-491 is a TNF-alpha converting enzyme inhibitor.
T27142	Delmitide	Rationally Designed Peptide-58,RDP-1258,RDP5,Allotrap-1258,RDP1258,RDP-5
	Delmitide, a TNF-alpha production inhibitor, is used potentially for the treatment of Crohn's disease and ulcerative colitis.
T76026	TNF-α (31-45), human TFA
	TNF-α (31-45), human (TFA) is a peptide of tumor necrosis factor-α. Tumour necrosis factor alpha (TNF alpha) is an inflammatory cytokine that induces necrosis or apoptosis [1] .
T71022	GI-129471
	GI-129471 is a metalloproteinase inhibitor, specifically blocking TNF-alpha secretion both in vitro and in vivo.
T64264	ISIS 104838
	ISIS 104838 is an antisense oligonucleotide that inhibits the production of tumour necrosis factor (TNF-alpha), which causes pain and swelling in rheumatoid arthritis joints.
T27507	GW-3333	GW 3333,GW3333
	GW-3333 is an matrix metalloproteinase inhibitor. It is also a tumor necrosis factor-alpha (TNF)-Converting Enzyme (TACE) inhibitor. The efficacy of GW3333 suggests that dual inhibitors of matrix metalloproteinases and T...
T69205	GGTI-2166
	GGTI-2166 is a geranylgeranyl transferase I inhibitor. GGTI-2166 inhibit the pOC formation induced by RANKL or TNF-alpha in cultures of both mouse marrow-derived macrophage-colony-stimulating factor (M-CSF) dependent mo...
T69716	Solimastat
	Solimastat is a novel oral, broad-spectrum matrix metalloproteinase inhibitor (MMPI), being >10-fold more active than marimastat in inhibiting the processing of cell-bound TNF-alpha.
T81606	Onercept
	Onercept, a recombinant soluble form of the human tumor necrosis factor-alpha (TNF-α) p55 receptor, is utilized in the study of Crohn's disease [1].
T70280	KB-R7785
	KB-R7785 is a novel ADAM12 and MMP inhibitor, ameliorating cardiac function in a transverse aortic constriction (TAC) model by inhibiting the proteolytic activation of HB-EGF signaling, exerting its antidiabetic effect b...
TP1615	IKKγ NBD Inhibitory Peptide
	A cell-permeable synthetic peptide NEMO-binding domain peptide (NBD peptide) corresponding to the NEMO amino-terminal alpha-helical region is shown to block TNF-alpha-induced NF-kB activation. The interaction of IKγNEMO ...
T78548	3-Hydroxyxanthone	3-Hydroxy-xanthen-9-one	Integrin
	3-Hydroxyxanthone (3-Hydroxy-xanthen-9-one), a xanthone derivative, exhibits inhibitory effects on NADPH-catalyzed lipid peroxidation in human umbilical vein endothelial cells (HUVECs) and suppresses TNF-alpha-induced IC...		Integrin
T69223	CC-1088
	CC-1088 is an analog of thalidomide with potential antineoplastic activity that belongs to the functional class of agents called selective cytokine inhibitory drugs (SelCIDs). SelCIDs inhibit phosphodiesterase-4 (PDE 4),...
T80973	TNF-α-IN-8
	TNF-α-IN-8 (compound I-42) is an isoindole-imide-based inhibitor of tumor necrosis factor-alpha (TNF-α) with applications in researching various diseases including cancer, heart disease, osteoporosis, and autoimmune diso...
T76963	Certolizumab pegol
	Certolizumab pegol (Certolizumab) is a recombinant, humanized monoclonal antibody fragment that has been modified with polyethylene glycol (PEG), which selectively targets and neutralizes tumor necrosis factor-alpha (TNF...
T72687	Keap1-Nrf2-IN-11
	Keap1-Nrf2-IN-11 (Compound 6k), a potent Keap1-Nrf2 inhibitor, exhibits a dissociation constant (KD) of 0.21 nM. It hampers the production of reactive oxygen species (ROS) and nitric oxide (NO), as well as the expression...
T36618	Rupatadine
	Rupatadine (UR-12592) is a potent dual PAF/H1 antagonist with Ki of 0.55/0.1 uM(rabbit platelet membranes/guinea pig cerebellum membranes).IC50 value:Target: PAF/H1 antagonistin vitro: Rupatadine competitively inhibited ...

Compounds

Synonym: TNF-α Antagonist III

Target: TNF

TNF-α (31-45), human acetate

T19584L

Synonym: TNF-α (31-45), human acetate(144796-71-4 free base)

Target: Others

Anti-Mouse TNF alpha Antibody (TN3-19.12)

T78272

Synonym:

Target:

TNF-α (46-65), human

TNF-α (31-45), human

T19584

Synonym:

Target: Others

TNF-α (10-36), human

TP1537

Synonym:

Target:

TNF-α (10-36), human (TFA) (144796-70-3 free base)

TP1479

Synonym: TNF-α (10-36), human (TFA)

Target: IL Receptor, TNF, COX, IFNAR, Interleukin

Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human) TFA

T78434

Synonym:

Target:

Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human)

T81838

Synonym:

Target:

TNF-α (31-45), human TFA (144796-71-4 free base)

TP1636

Synonym: TNF-α (31-45), human TFA

Target:

TNF-α (46-65), human TFA (144796-72-5 free base)

TP1669

Synonym: TNF-α (46-65), human TFA

IKKγ NBD Inhibitory Peptide acetate

TP1615L

Synonym: IKKγ NBD Inhibitory Peptide acetate(372146-18-4 free base)

Target: NF-κB

Roquinimex

T4412

Synonym: Linomide,LS2616,FCF89,ABR212616

Synonym: SP100030,SP 100030

Target: NF-κB

N-Formyl-Met-Leu-Phe

T7091

Synonym: fMLP,N-Formyl-MLF

Target: TNF

Rebamipide

T1562

Synonym: Proamipide,OPC12759

Target: Free radical scavengers, COX, Prostaglandin Receptor

Synonym: AN 0128,CRM-0005,CRM0005,ONT0001,AN-0128,ONT-0001

Synonym: Rationally Designed Peptide-58,RDP-1258,RDP5,Allotrap-1258,RDP1258,RDP-5

Target:

TNF-α (31-45), human TFA

Synonym: GW 3333,GW3333

IKKγ NBD Inhibitory Peptide

Synonym: 3-Hydroxy-xanthen-9-one

Cat No.	Product Name	Synonyms	Targets
T5660	Menthone		IL Receptor , TNF , NF-κB , Parasite
	Menthone has anti-inflammary activity,, it can suppress the lipopolysaccharide (LPS)-induced proinflammatory cytokines, interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha),as well as nuclear factor k...		IL Receptor , TNF , NF-κB , Parasite
T3927	Phellopterin		GABA Receptor
	Phellopterin is a partial agonist of the central benzodiazepine receptors in vitro. Phellopterin shows a cytotoxic effect on RAW264.7 cell at the concentration from 40 to 400 μM. Phellopterin reduce TNF-alpha-induced VCA...		GABA Receptor
T3805	Prim-O-glucosylcimifugin	Cimifugin beta-D-glucopyranoside,Cimifugin 7-glucoside	TNF , COX , JAK , NO Synthase
	Prim-O-glucosylcimifugin (Cimifugin 7-glucoside) can inhibit the proliferation of SMC(smooth muscle cell) stimulated by TNF-alpha, increase the proportion of G0/G1 phase.		TNF , COX , JAK , NO Synthase
T4S0795	Berberrubine chloride	9-Berberoline Chloride,Beroline,Beroline Chloride,Berberrubine,9-Berberoline	IL Receptor
	1. Berberrubine chloride (9-Berberoline Chloride) has antitumor activity. 2. Berberrubine has antidiabetic activity. 3. Berberrubine dose-dependently inhibits IL-8 and MCP-1 protein levels in the media and mRNA expressio...		IL Receptor
T6S1256	Ruscogenin		NOS , NF-κB , NOD-like Receptor (NLR)
	1. Ruscogenin has anti-inflammatory activity, suppressed zymosan A-evoked peritoneal total leukocyte migration in mice in a dose-dependent manner, 2. Ruscogenin inhibited adhesion of leukocytes to a human umbilical vein ...		NOS , NF-κB , NOD-like Receptor (NLR)
T2823	Crocin	Gardenia Yellow,Alpha-Crocin	Others
	Crocin (Gardenia Yellow) is a water-soluble carotenoid pigment of saffron (Crocus sativus L. ) that has been used as a spice for flavoring and coloring food preparations, and in Chinese traditional medicine as an anodyne...		Others
T4S1615	Sanggenon C	Sanggenone C	NF-κB
	1. Sanggenon C (Sanggenone C) inhibits tumor cellular proteasomal activity and cell viability, via induction of cell cycle arrest and cell death , inhibiting the proteasome function. 2. Sanggenon C and O inhibited NO pro...		NF-κB
T3893	Forsythoside B		TNF , NF-κB
	Forsythoside B binds to LPS and reduces the biological activity of serum LPS, and inhibits NF-κB activation. Forsythoside B inhibits the inflammatory response and has antioxidant properties. Potent neuroprotective effect...		TNF , NF-κB
TMA0627	Taxiresinol		TNF
	Taxiresinol shows anticancer, antinociceptive, and antiallergic activities, it shows inhibitory activity on induced histamine release from the human basophilic cell line, KU812. Taxiresinol can protect the hepatocytes fr...		TNF
TN4243	Hyuganin D		TNF
	Hyuganin D can inhibit LPS-induced NO and/or TNF-alpha production in mouse peritoneal macrophages.		TNF
TN1458	Buddlejasaponin IV		PARP , Akt , Chk
	Buddlejasaponin IV has analgesic and anti-inflammatory effects, the inhibitions of the expressions of iNOS, COX-2, TNF-alpha, IL-1beta and IL-6 by blocking NF-kappaB activation.		PARP , Akt , Chk
TMA2576	Episappanol		IL Receptor , TNF
	Episappanol has anti-inflammatory activity , it can significantly inhibit the secretion of the pro-inflammatory cytokines interleukin (IL-6) and tumor necrosis factor-alpha (TNF-α).		IL Receptor , TNF
TN4334	Isotaxiresinol		TNF
	Isotaxiresinol prevents d-GalN/LPS-induced hepatic injury by inhibiting hepatocyte apoptosis through the blocking of TNF-alpha and IFN-gamma production by activated macrophages and direct inhibition of the apoptosis indu...		TNF
TN5351	Cycloshizukaol A
	Cycloshizukaol A prevents monocyte adhesion to HUVEC through the inhibition of cell adhesion molecules expression stimulated by TNF-alpha, it inhibits PMA-induced homotypic aggregation of HL-60 cells without cytotoxicity...
TN4303	Isokaempferide		ATPase , Potassium Channel , Calcium Channel , TNF , Prostaglandin Receptor
	Isokaempferide shows hepatoprotective, antiproliferative, and anti-inflammatory effects, the anti-inflammatory effects can be explained, at least in part, by reducing neutrophil degranulation, myeloperoxidase activity, m...
TN4146	Glutinol acetate		TNF
	Glutinol acetate shows significant cytotoxic activity against four human cancer cell lines (HL-60, SK-OV-3, A549, and HT-29), with GI(50) in the range of 11.1-17.9microM; it also has anti-inflammatory effect, exhibits mo...		TNF
TN5474	Bonducellin
	Bonducellin has anti-inflammatory activities, it can significantly and dose-dependently inhibit the inflammatory mediators; nitric oxide (NO), and cytokines [tumor necrosis factor (TNF)-alpha and interleukin (IL)-12. Bon...
TN2243	Sugiol	10-Deoxoxanthoperol	IL Receptor , TNF , ROS
	Sugiol (10-Deoxoxanthoperol) has antioxidant efficacy, it has significant scavenging activities of 1,1-diphenyl-2-picryl hydrazyl, nitric oxide, superoxide and hydroxyl free radicals. Sugiol's efficacy in inhibiting the ...		IL Receptor , TNF , ROS
TN5011	Shizukaol B		ERK , IL Receptor , p38 MAPK , TNF , NOS , NF-κB , COX , HIV Protease , DNA/RNA Synthesis , Prostaglandin Receptor , JNK
	Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinflammatory effects by inhibiting nitric-oxide (NO) production...

Natural Products

Menthone

T5660

Synonym:

Target: IL Receptor, TNF, NF-κB, Parasite

Phellopterin

T3927

Synonym:

Target: GABA Receptor

Prim-O-glucosylcimifugin

T3805

Synonym: Cimifugin beta-D-glucopyranoside,Cimifugin 7-glucoside

Target: TNF, COX, JAK, NO Synthase

Berberrubine chloride

T4S0795

Synonym: 9-Berberoline Chloride,Beroline,Beroline Chloride,Berberrubine,9-Berberoline

Target: NOS, NF-κB, NOD-like Receptor (NLR)

Crocin

T2823

Synonym: Gardenia Yellow,Alpha-Crocin

Target: Others

Sanggenon C

T4S1615

Synonym: Sanggenone C

Target: PARP, Akt, Chk

Episappanol

TMA2576

Synonym:

Target: IL Receptor, TNF

Target: ATPase, Potassium Channel, Calcium Channel, TNF, Prostaglandin Receptor

Synonym: 10-Deoxoxanthoperol

Target: IL Receptor, TNF, ROS

Shizukaol B

TN5011

Synonym:

Target: ERK, IL Receptor, p38 MAPK, TNF, NOS, NF-κB, COX, HIV Protease, DNA/RNA Synthesis, Prostaglandin Receptor, JNK

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-00936	TNF alpha Protein, Human, Recombinant	Human	E. coli
	TNF alpha Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.5 kDa and the accession number is P01375.
TMPY-01294	TNF alpha Protein, Mouse, Recombinant	Mouse	E. coli
	TNF alpha Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.39 kDa and the accession number is P06804.
TMPJ-00779	TNF alpha Protein, Rabbit, Recombinant	Rabbit	E. coli
	Tumor necrosis factor alpha (TNFα) is the prototypic ligand of the TNF superfamily. TNFα forms a homotrimer and functions by activating two types of receptors TNF-R1 (TNF receptor type 1,p55R) and TNF-R2 (TNF receptor ty...
TMPY-04146	TNF alpha Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	TNF alpha Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.8 kDa and the accession number is P01375.
TMPY-02202	TNF alpha Protein, Rat, Recombinant	Rat	E. coli
	TNF alpha Protein, Rat, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.4 kDa and the accession number is P16599.
TMPY-05187	TNF alpha Protein, Mouse, Recombinant, Biotinylated	Mouse	E. coli
	TNF alpha Protein, Mouse, Recombinant, Biotinylated is expressed in E. coli expression system. The predicted molecular weight is 17.4 kDa and the accession number is P06804.
TMPK-00583	TNF alpha Protein, Ferret, Recombinant (His)	Ferret	E. coli
	TNF alpha Protein, Ferret, Recombinant (His) is expressed in E. coli expression system with C-His tag. The predicted molecular weight is 18.88 kDa and the accession number is A3FBF1.
TMPK-00119	TNF alpha Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	TNF alpha Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weight is 18.35 kDa and the accession number is P79337.
TMPY-05237	TNF alpha Protein, Human, Recombinant, Biotinylated	Human	E. coli
	TNF alpha Protein, Human, Recombinant, Biotinylated is expressed in E. coli expression system. The predicted molecular weight is 17.5 kDa and the accession number is P01375.
TMPK-00120	TNF alpha Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	TNF alpha Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 20.3 kDa and the accession number is P01375.
TMPK-00121	TNF alpha Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	TNF alpha Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 20.3 kDa and the accession number is P01375.
TMPJ-00125	TNF alpha Protein, Human, Recombinant (aa 57-233, His)	Human	E. coli
	TNF alpha Protein, Human, Recombinant (aa 57-233, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 18 KDa and the accession number is P01375.
TMPJ-00124	TNF alpha Protein, Human, Recombinant (aa 77-233, His)	Human	E. coli
	TNF alpha Protein, Human, Recombinant (aa 77-233, His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 16 KDa and the accession number is P01375.
TMPY-02153	TNF beta Protein, Human, Recombinant	Human	E. coli
	Lymphotoxin-alpha, also known as LT-alpha, TNF-beta, Tumor necrosis factor ligand superfamily member 1, LTA TNFSF1, and TNFB, is a secreted protein that belongs to the tumor necrosis factor family. TNF-beta/TNFSF1/Lympho...
TMPY-01594	TNF alpha Protein, Canine, Recombinant	Canine	E. coli
	TNF alpha Protein, Canine, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.3 kDa and the accession number is A9LMQ0.
TMPY-02226	TNF alpha Protein, Ferret, Recombinant	Ferret	E. coli
	TNF alpha Protein, Ferret, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.3 kDa and the accession number is A3FBF1.
TMPY-02069	TNF alpha Protein, Cynomolgus, Rhesus, Recombinant	Cynomolgus,Rhesus	E. coli
	TNF alpha Protein, Cynomolgus, Rhesus, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.4 kDa and the accession number is NP_001040614.1.
TMPY-05516	TNF alpha Protein, Cynomolgus, Recombinant, Biotinylated	Cynomolgus	E. coli
	TNF alpha Protein, Cynomolgus, Recombinant, Biotinylated is expressed in E. coli expression system. The predicted molecular weight is 17.4 kDa and the accession number is P79337.
TMPH-03745	TNF-alpha Protein, Zebrafish, Recombinant (His)	Danio rerio (Zebrafish)	E. coli
	TNF-alpha Protein, Zebrafish, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 23.6 kDa and the accession number is Q08CQ3.
TMPJ-00288	TNF RII Protein, Human, Recombinant (mFc)	Human	HEK293 Cells
	TNF RII Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 60 KDa and the accession number is P20333.
TMPJ-00287	TNF RII Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	TNF RII Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 60-90 KDa and the accession number is P20333.
TMPJ-00546	EFNA1 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Ephrin-A1 is a member of the A-type ephrin family of cell surface proteins that function as ligands for the A-type Eph receptor tyrosine kinase family. Ephrin-A1 can be induced by TNF and IL1B. Its expression levels can ...
TMPY-06981	IL-1 alpha/IL-1A Protein, Human, Recombinant (E. coli)	Human	E. coli
	IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proli...
TMPJ-01172	IL-17 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. Mature mouse IL-17A shares 61% and 89% amino acid seque...
TMPK-01382	TNFR2/CD120b/TNFR1B Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	Tumor Necrosis Factor Receptor II (TNF RII), also known as TNFRSF1B, p75/p80, and CD120b, is a type I transmembrane protein that belongs to the TNF receptor superfamily. It has a molecular weight of approximately 75 kDa....
TMPY-03416	TNFAIP8 Protein, Human, Recombinant (His)	Human	E. coli
	Tumor necrosis factor (TNF)-alpha-induced protein 8 (TNFAIP8) family is a newly identified protein with vital roles in maintaining immune homeostasis. Tumor necrosis factor-alpha-inducible protein 8 (TNFAIP8) is a TNF-al...
TMPJ-01107	PAP Protein, Human, Recombinant (His)	Human	E. coli
	Human PAP, also known as 28 kDa heat- and acid-stable phosphoprotein, PDGF-associated protein, PDGFA-associated protein 1, PDAP1, HASPP28, is a protein which belongs to the PDAP1 family. The encoded protein in rodents ha...
TMPK-00564	TNFR1/CD120a/TNFRSF1A Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	Tumour necrosis factor alpha (TNF-α) is a pleiotropic cytokine with both injurious and protective functions, which are thought to diverge at the level of its two cell surface receptors, TNFR1 and TNFR2. In the setting of...
TMPH-02195	TXNDC17 Protein, Human, Recombinant (GST)	Human	E. coli
	Disulfide reductase. May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Modulates TNF-alpha signalin...
TMPH-02650	FCMR/FAIM3 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory...
TMPJ-00930	VCAM-1 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	Vascular cell adhesion molecule 1 (VCAM-1) is a cell surface protein belonging to the immunoglobulin superfamily, the protein is expressed by activated endothelial cells and certain leukocytes (such as macrophages). IL-1...
TMPY-02246	HB-EGF Protein, Human, Recombinant	Human	Baculovirus Insect Cells
	Heparin-binding EGF-like growth factor (HBEGF), a member of the EGF family of growth factors, exerts its biological activity through activation of the EGFR and other ErbB receptors. Soluble mature HBEGF is proteolyticall...
TMPJ-00109	LMIR2 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	CD300C is a single-pass type I membrane protein which belongs to the immunoregulatory signaling (IRS) family. CD300C contains one Ig-like V-type domain and is present on the surface of natural killer cells, granulocytes,...
TMPH-01559	IL-26 Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expre...
TMPH-01560	IL-26 Protein, Human, Recombinant (His & Trx)	Human	E. coli
	May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expre...
TMPH-02876	RIPK1 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways. Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold fun...
TMPH-02287	ZRANB1 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pat...
TMPY-04412	Germinal Center Kinase/MAP4K2 Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	Mitogen-activated protein kinase kinase kinase kinase 2, also known as B lymphocyte serine/threonine-protein kinase, Germinal center kinase, MAPK/ERK kinase kinase kinase 2, MEK kinase kinase 2, Rab8-interacting protein,...
TMPJ-01444	IL-17A Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. As IL-17 shares properties with IL-1 and TNF-alpha, it ...
TMPK-01103	LILRA3/CD85e Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	Human LILRA3, also known as Leukocyte Ig-like receptor 4 (LIR-4), CD85 antigen-like family member E, Immunogobulin-like transcript 6 (ILT-6) and monocyte inhibitory receptor HM43/HM31, is a 70 kD Ig superfamily member t...
TMPY-00248	Lymphotoxin Beta Protein, Cynomolgus, Recombinant (His)	Cynomolgus	Baculovirus Insect Cells
	LTB (Lymphotoxin Beta) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surfa...
TMPJ-01187	Siglec-E Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	Siglecs are sialic acid specific I‑type lectins that are characterized by an extracellular domain (ECD) with an N‑terminal Ig‑like V‑set domain followed by varying numbers of Ig‑like C2‑set domains. Mouse Siglec‑E, also ...
TMPY-01033	IL-32 Protein, Human, Recombinant (isoform alpha, His)	Human	HEK293 Cells
	IL-32 is a recently discovered cytokine that induces various proinflammatory cytokines (TNF-alpha, IL-1beta, IL-6) and chemokines in both human and mouse cells through the NF-kappaB and p38 MAPK inflammatory signal pathw...
TMPH-02878	PTPRS Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycans. Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects...
TMPY-03308	ADAM17 Protein, Rat, Recombinant (His)	Rat	HEK293 Cells
	ADAM17 is a member of the ADAM protein family of disintegrins and metalloproteases. ADAM17 is ubiquitously expressed in the human colon, with increased activity in the colonic mucosa of patients with ulcerative coliti...

TNF alpha Protein, Human, Recombinant

TMPY-00936

Species: Human

Expression System: E. coli

TNF alpha Protein, Mouse, Recombinant

TMPY-01294

Species: Mouse

Expression System: E. coli

TNF alpha Protein, Rabbit, Recombinant

TMPJ-00779

Species: Rabbit

Expression System: E. coli

TNF alpha Protein, Human, Recombinant (hFc)

TMPY-04146

Species: Human

Expression System: HEK293 Cells

TNF alpha Protein, Rat, Recombinant

TMPY-02202

Species: Rat

Expression System: E. coli

TNF alpha Protein, Mouse, Recombinant, Biotinylated

TMPY-05187

Species: Mouse

Expression System: E. coli

TNF alpha Protein, Ferret, Recombinant (His)

TMPK-00583

Species: Ferret

Expression System: E. coli

TNF alpha Protein, Cynomolgus, Recombinant (His)

TMPK-00119

Species: Cynomolgus

Expression System: HEK293 Cells

TNF alpha Protein, Human, Recombinant, Biotinylated

TMPY-05237

Species: Human

Expression System: E. coli

TNF alpha Protein, Human, Recombinant (His & Avi)

TMPK-00120

Species: Human

Expression System: HEK293 Cells

TNF alpha Protein, Human, Recombinant (His & Avi), Biotinylated

TMPK-00121

Species: Human

Expression System: HEK293 Cells

TNF alpha Protein, Human, Recombinant (aa 57-233, His)

TMPJ-00125

Species: Human

Expression System: E. coli

TNF alpha Protein, Human, Recombinant (aa 77-233, His)

TMPJ-00124

Species: Human

Expression System: E. coli

TNF beta Protein, Human, Recombinant

TMPY-02153

Species: Human

Expression System: E. coli

TNF alpha Protein, Canine, Recombinant

TMPY-01594

Species: Canine

Expression System: E. coli

TNF alpha Protein, Ferret, Recombinant

TMPY-02226

Species: Ferret

Expression System: E. coli

TNF alpha Protein, Cynomolgus, Rhesus, Recombinant

TMPY-02069

Species: Cynomolgus,Rhesus

Expression System: E. coli

TNF alpha Protein, Cynomolgus, Recombinant, Biotinylated

TMPY-05516

Species: Cynomolgus

Expression System: E. coli

TNF-alpha Protein, Zebrafish, Recombinant (His)

TMPH-03745

Species: Danio rerio (Zebrafish)

Expression System: E. coli

TNF RII Protein, Human, Recombinant (mFc)

TMPJ-00288

Species: Human

Expression System: HEK293 Cells

TNF RII Protein, Human, Recombinant (hFc)

TMPJ-00287

Species: Human

Expression System: HEK293 Cells

EFNA1 Protein, Human, Recombinant (hFc)

TMPJ-00546

Species: Human

Expression System: HEK293 Cells

IL-1 alpha/IL-1A Protein, Human, Recombinant (E. coli)

TMPY-06981

Species: Human

Expression System: E. coli

IL-17 Protein, Mouse, Recombinant (His)

TMPJ-01172

Species: Mouse

Expression System: HEK293 Cells

TNFR2/CD120b/TNFR1B Protein, Cynomolgus, Recombinant (His)

TMPK-01382

Species: Cynomolgus

Expression System: HEK293 Cells

TNFAIP8 Protein, Human, Recombinant (His)

TMPY-03416

Species: Human

Expression System: E. coli

PAP Protein, Human, Recombinant (His)

TMPJ-01107

Species: Human

Expression System: E. coli

TNFR1/CD120a/TNFRSF1A Protein, Cynomolgus, Recombinant (His)

TMPK-00564

Species: Cynomolgus

Expression System: HEK293 Cells

TXNDC17 Protein, Human, Recombinant (GST)

TMPH-02195

Species: Human

Expression System: E. coli

FCMR/FAIM3 Protein, Mouse, Recombinant (His & SUMO)

TMPH-02650

Species: Mouse

Expression System: E. coli

VCAM-1 Protein, Mouse, Recombinant (hFc)

TMPJ-00930

Species: Mouse

Expression System: HEK293 Cells

HB-EGF Protein, Human, Recombinant

TMPY-02246

Species: Human

Expression System: Baculovirus Insect Cells

LMIR2 Protein, Human, Recombinant (hFc)

TMPJ-00109

Species: Human

Expression System: HEK293 Cells

IL-26 Protein, Human, Recombinant (His)

TMPH-01559

Species: Human

Expression System: P. pastoris (Yeast)

IL-26 Protein, Human, Recombinant (His & Trx)

TMPH-01560

Species: Human

Expression System: E. coli

RIPK1 Protein, Mouse, Recombinant (His)

TMPH-02876

Species: Mouse

Expression System: E. coli

ZRANB1 Protein, Human, Recombinant (His & Myc)

TMPH-02287

Species: Human

Expression System: E. coli

Germinal Center Kinase/MAP4K2 Protein, Human, Recombinant (His & GST)

TMPY-04412

Species: Human

Expression System: Baculovirus Insect Cells

IL-17A Protein, Cynomolgus, Recombinant (His)

TMPJ-01444

Species: Cynomolgus

Expression System: HEK293 Cells

LILRA3/CD85e Protein, Human, Recombinant (His & Avi)

TMPK-01103

Species: Human

Expression System: HEK293 Cells

Lymphotoxin Beta Protein, Cynomolgus, Recombinant (His)

TMPY-00248

Species: Cynomolgus

Expression System: Baculovirus Insect Cells

Siglec-E Protein, Mouse, Recombinant (hFc)

TMPJ-01187

Species: Mouse

Expression System: HEK293 Cells

IL-32 Protein, Human, Recombinant (isoform alpha, His)

TMPY-01033

Species: Human

Expression System: HEK293 Cells

PTPRS Protein, Mouse, Recombinant (His & Myc)

TMPH-02878

Species: Mouse

Expression System: E. coli

ADAM17 Protein, Rat, Recombinant (His)

TMPY-03308

Species: Rat

Expression System: HEK293 Cells

Cat No.	Product Name
L4700	Immunology/Inflammation Compound Library	4720 compounds
	A unique collection of 4720 anti-inflammation compounds effective for high throughput screening and high content screening.
L9810	Anti-Fibrosis Compound Library	1155 compounds
	A unique collection of 1155 potential anti-fibrosis compounds, can be used in HTS and HCS;

Libraries

Immunology/Inflammation Compound Library

L4700

Compounds: 4720

Anti-Fibrosis Compound Library

L9810

Compounds: 1155