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AX-024 hydrochloride

Catalog No. T4403 CAS 1704801-24-0

Synonyms: AX-024 HCl

AX-024 hydrochloride (AX-024 HCl) is an cytokine release inhibitor which can strongly inhibit the production of interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), interferon-γ (IFN-γ), IL-10 and IL-17A.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

AX-024 hydrochloride, CAS 1704801-24-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 52.00
2 mg	In stock	$ 75.00
5 mg	In stock	$ 117.00
10 mg	In stock	$ 179.00
25 mg	In stock	$ 417.00
50 mg	In stock	$ 619.00
100 mg	In stock	$ 879.00
1 mL * 10 mM (in DMSO)	In stock	$ 138.00

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Purity: 99.9%

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Description	AX-024 hydrochloride (AX-024 HCl) is an cytokine release inhibitor which can strongly inhibit the production of interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), interferon-γ (IFN-γ), IL-10 and IL-17A.
In vitro	Compound AX-024 hydrochloride exhibits over 10,000 times greater efficacy than its precursor, AX-000, in inhibiting TCR-triggered T cell proliferation, with an IC50 value of 1 nM and showing effects at concentrations as low as 1 pM. Additionally, it significantly outperforms AX-000 in suppressing cytokine release from human peripheral blood mononuclear cells activated with anti-CD3, effectively reducing the production of IL-6, TNFα, IFN-γ, IL-10, and IL-17A at a 10 nM concentration. In OT1 TCR transgenic (OT1Tg) mice with wild-type (WT) cells, AX-024 hydrochloride robustly inhibits T cell proliferation at a 0.1 nM concentration when the OT1Tg T cells are WT for the PRS mutation. Furthermore, coimmunoprecipitation experiments have demonstrated that Nck recruitment to the TCR is blocked by AX-024 hydrochloride in a concentration-dependent manner starting at 1 nM, indicating the compound's potent inhibitory action on T cell activation processes.
In vivo	Treatment with AX-024 hydrochloride results in a significant reduction of scales and skin thickening when compared to the vehicle-treated group, demonstrating particular effectiveness in diminishing the thickening of the dermis to levels akin to those observed in mice treated with a control cream without imiquimod (IMQ). Additionally, administration of AX-024 hydrochloride notably reduces the number of airway inflammatory cells and facilitates rapid recovery from neurological impairment and weight loss in mice. By day 30, mice treated with AX-024 hydrochloride become symptom-free, contrasting sharply with vehicle-treated mice, which continue to exhibit symptoms such as ataxia and loss of the righting reflex.
Cell Research	Spleen B cells from C57BL/6 mice are labeled with Cell Trace Violet and incubated for 72 hours with either anti-IgM (10 mg/mL) or anti-CD40 (5 mg/mL), supplemented with IL-4 (5 ng/mL) or LPS (2.5 mg/mL) in the presence of different concentrations of AX-024 hydrochloride. Proliferation is calculated according to the total number of cell divisions. They are for reference only.
Animal Research	Eight-week-old CD-1 mice are injected intraperitoneally with different amounts of the AX-024 hydrochloride dissolved in 0.5 mL of saline. All animals are observed Clinically for the appearance of macroscopically visible adverse reactions twice daily over 14 days, as well as immediately after AX-024 hydrochloride administration. A necropsy is carried out on each animal on day 14, and the abdominal, thoracic, and cranial cavities are examined in situ, together with their associated organs. They are for reference only.

Synonyms	AX-024 HCl
Molecular Weight	375.87
Formula	C21H23ClFNO2
CAS No.	1704801-24-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 33 mg/mL

References and Literature

1. Borroto A, etal. First-in-class inhibitor of the T cell receptor for the treatment of autoimmune diseases. Sci Transl Med. 2016 Dec 21;8(370):370ra184.

Citations

1. Li Y, Lai J, Ran M, et al.Alnustone promotes megakaryocyte differentiation and platelet production via the interleukin-17A/interleukin-17A receptor/Src/RAC1/MEK/ERK signaling pathway.European Journal of Pharmacology.2024: 176548.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Neurodegenerative Disease Compound Library Anti-Cancer Drug Library Drug Repurposing Compound Library Anti-Cancer Active Compound Library Anti-Cancer Clinical Compound Library NF-κB Signaling Compound Library Bioactive Compound Library PPI Inhibitor Library Anti-Cancer Compound Library

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Keywords

AX-024 hydrochloride 1704801-24-0 Apoptosis Immunology/Inflammation Neuroscience IFNAR COX TNF IL Receptor Interleukin AX 024 Interleukin Related Inhibitor AX024 Hydrochloride inhibit Tumor Necrosis Factor Receptor AX024 hydrochloride AX 024 Hydrochloride AX-024 HCl TNFR Interferon-α/β receptor AX024 AX-024 AX-024 Hydrochloride TNF Receptor AX 024 hydrochloride Interferon-alpha/beta receptor inhibitor

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