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Ruscogenin

Catalog No. T6S1256   CAS 472-11-7

1. Ruscogenin has anti-inflammatory activity, suppressed zymosan A-evoked peritoneal total leukocyte migration in mice in a dose-dependent manner, 2. Ruscogenin inhibited adhesion of leukocytes to a human umbilical vein endothelial cell line (ECV34) injured by tumor necrosis factor-alpha (TNF-alpha) in a concentration-dependent manner. 3. Ruscogenin significantly attenuate LPS-induced acute lung injury via inhibiting expressions of TF and iNOS and NF-kappa B p65 activation.

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Ruscogenin Chemical Structure
Ruscogenin, CAS 472-11-7
Pack Size Availability Price/USD Quantity
1 mg In stock $ 36.00
5 mg In stock $ 79.00
10 mg In stock $ 117.00
25 mg In stock $ 195.00
50 mg In stock $ 288.00
100 mg In stock $ 433.00
1 mL * 10 mM (in DMSO) In stock $ 87.00
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Purity: 99.69%
Purity: 98.12%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description 1. Ruscogenin has anti-inflammatory activity, suppressed zymosan A-evoked peritoneal total leukocyte migration in mice in a dose-dependent manner, 2. Ruscogenin inhibited adhesion of leukocytes to a human umbilical vein endothelial cell line (ECV34) injured by tumor necrosis factor-alpha (TNF-alpha) in a concentration-dependent manner. 3. Ruscogenin significantly attenuate LPS-induced acute lung injury via inhibiting expressions of TF and iNOS and NF-kappa B p65 activation.
Source
Molecular Weight 430.62
Formula C27H42O4
CAS No. 472-11-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 78 mg/mL(181.1 mM)

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble

TargetMolReferences and Literature

1. Huang Y L , Kou J P , Ma L , et al. Possible Mechanism of the Anti-inflammatory Activity of Ruscogenin: Role of Intercellular Adhesion Molecule1 and Nuclear Factor-κB[J]. Journal of Pharmacological Sciences, 2008, 108(2):198-205.

Related compound libraries

This product is contained In the following compound libraries:
Traditional Chinese Medicine Monomer Library Inhibitor Library Natural Product Library Natural Product Library for HTS Anti-Inflammatory Traditional Chinese Medicine Compound Library Oxidation-Reduction Compound Library Anti-Ovarian Cancer Compound Library Anti-Liver Cancer Compound Library NF-κB Signaling Compound Library HIF-1 Signaling Pathway Compound Library

Related Products

Related compounds with same targets
Dehydromiltirone (Z)-SU4312 NOS-IN-1  2-Iminobiotin hydrobromide Isofuranodiene Goshonoside F5 7-Nitroindazole 6-Dehydrogingerdione

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Keywords

Ruscogenin 472-11-7 Immunology/Inflammation NF-Κb NOD-like Receptor (NLR) NF-κB NOS inhibit Inhibitor inhibitor

 

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