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Shizukaol B

Catalog No. TN5011 CAS 142279-40-1

Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinflammatory effects by inhibiting nitric-oxide (NO) production in lipopolysaccharide (LPS)-stimulated murine BV-2 microglial cells with relatively low cytotoxicity. Shizukaol B exhibits anti-HIV-1 replication activities in both wild-type HIV-1 and two NNRTIs-resistant strains, it also has significant cytotoxicities against C8166 cells. Shizukaol B prevents monocyte adhesion to HUVEC through the inhibition of cell adhesion molecules expression stimulated by TNF-alpha.

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Shizukaol B, CAS 142279-40-1

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Molecular Weight	732.77
Formula	C40H44O13
CAS No.	142279-40-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Related Products

Related compounds with same targets

Shizukaol B Riddelline Horminone 1-Decarboxy-3-oxo-ceanothic acid Dihydroguaiaretic acid α-Chaconine Dehydroglyasperin D Datelliptium chloride

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Shizukaol B 142279-40-1 DNA损伤和修复 G蛋白偶联受体 MAPK信号通路 NF-Kb信号通路蛋白酶体凋亡免疫与炎症神经科学微生物学细胞周期 DNA/RNA Synthesis ERK COX NF-κB NOS HIV Protease IL Receptor JNK p38 MAPK Prostaglandin Receptor TNF Inhibitor inhibitor inhibit

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