Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SP-100030 is a dual inhibitor of NF-κB and activator protein-1 (AP-1), demonstrating potent inhibition with IC50 values of 50 nM for both. It effectively reduces the production of IL-2, IL-8, and TNF-alpha in Jurkat and other T cell lines. Additionally, SP-100030 has been shown to decrease the severity of murine collagen-induced arthritis (CIA).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 47.00 | |
5 mg | In stock | $ 113.00 | |
10 mg | In stock | $ 178.00 | |
25 mg | In stock | $ 425.00 | |
50 mg | In stock | $ 685.00 | |
100 mg | In stock | $ 953.00 | |
500 mg | In stock | $ 1,850.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 125.00 |
Description | SP-100030 is a dual inhibitor of NF-κB and activator protein-1 (AP-1), demonstrating potent inhibition with IC50 values of 50 nM for both. It effectively reduces the production of IL-2, IL-8, and TNF-alpha in Jurkat and other T cell lines. Additionally, SP-100030 has been shown to decrease the severity of murine collagen-induced arthritis (CIA). |
In vitro | SP-100030 blocks the production of IL-2 and IL-8 in Jurkat T-cells at the same concentrations as seen in the luciferase assay (IC50≈30 nM)[1]. ELISA and RT-PCR confirmed that IL-2, IL-8, and TNF-alpha production by activated Jurkat and other T cell lines were inhibited by SP100030[2]. |
In vivo | SP100030 (10 mg/kg/day; i.p.; day 21 to day 34) significantly decreased arthritis severity[2]. |
Synonyms | SP100030, SP 100030 |
Molecular Weight | 437.65 |
Formula | C14H5ClF9N3O |
CAS No. | 154563-54-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (102.8 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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SP-100030 154563-54-9 NF-Κb NF-κB SP100030 SP 100030 inhibitor inhibit