Search Result

Search Results for " tlr4 "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T8503	TLR4-IN-C34		TLR
	TLR4-IN-C34 is an inhibitor of TLR4, and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis		TLR
T7672	MD2-TLR4-IN-1		TLR
	MD2-TLR4-IN-1 is a myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex inhibitor.		TLR
T38547	TLR4-IN-C34-C2-COOH	TLR4-IN-C34-C2-COOH
	TLR4-IN-C34-C2-COO is a linker compound that incorporates TLR4 inhibitor TLR4-IN-C34. It effectively inhibits TLR4 activity in enterocytes and macrophages. Moreover, it demonstrates a notable ability to mitigate systemic...
T80978	TLR4 agonist-1
	TLR4 agonist-1 (compound 17a) serves as a potent activator of Toll-like Receptor 4 (TLR4) and stimulates the production of MIP-1β in RAW 264.7 and MM6 cells [1].
T80977	TLR4 agonist-1 TEA
	TLR4 agonist-1 (TEA, compound 17a) is a potent activator of Toll-like Receptor 4 (TLR4) and prompts the production of MIP-1β in RAW 264.7 and MM6 cells [1].
T62359	TLR4/NF-κB/MAPK-IN-1
	TLR4/NF-κB/MAPK-IN-1 is a novel antineuroinflammatory agent that functions by inhibiting the TLR4/NF-κB/MAPK pathways.
T74383	TLR4-IN-C34-C2-amide-C6-OH
	TLR4-IN-C34-C2-amide-C6-OH, a chemical compound, serves as a linker encompassing the TLR4 inhibitor TLR4-IN-C34. This inhibitor is known to target TLR4 in enterocytes and macrophages, effectively reducing systemic inflam...
T74387	Tri(TLR4-IN-C34-C2-amide-PEG1)-amide-C3-COOH
	Tri(TLR4-IN-C34-C2-amide-PEG1)-amide-C3-COOH is a chemical linker featuring the TLR4 inhibitor TLR4-IN-C34, known for inhibition of TLR4 in enterocytes and macrophages, thereby diminishing systemic inflammation in mouse ...
T40423	L48H37
	L48H37 is a chemically stable analog of Curcumin. It exhibits potent inhibitory properties against myeloid differentiation protein 2 (MD2), acting as a specific inhibitor. Its mechanism involves inhibiting the interactio...
T74388	Tri(TLR4-IN-C34-PEG2-amide-PEG1)-amide-C3-COOH
	Tri(TLR4-IN-C34-PEG2-amide-PEG1)-amide-C3-COOH is a chemical linker incorporating the TLR4 inhibitor, TLR4-IN-C34, which suppresses TLR4 activity in enterocytes and macrophages, consequently diminishing systemic inflamma...
T74389	Tri(TLR4-IN-C34-C2-amide-C3-amide-PEG1)-amide-C3-COOH
	Tri(TLR4-IN-C34-C2-amide-C3-amide-PEG1)-amide-C3-COOH, a chemical compound, serves as a linker incorporating TLR4 inhibitor TLR4-IN-C34. This compound effectively inhibits TLR4 in both enterocytes and macrophages, signif...
T21826	TC-E 5003	NSC 30176	Histone Methyltransferase
	TC-E 5003 (NSC-30176) is a selective inhibitor of PRMT1 with IC50 of 1.5 μM.		Histone Methyltransferase
TP1938	RS 09		TLR
	TLR4 agonist. Promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages in vitro. Acts as an adjuvant in vivo; enhances X-15 specific antibody serum concentrations, when adm...		TLR
T11598	IAXO-102		TLR
	IAXO-102 is a TLR4 antagonist that negatively regulates TLR4 signaling. It inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinflammatory protein. IAXO-102 also prevents experimental abdomin...		TLR
T37292	M62812		TLR
	TLR4 inhibitor. Inhibits LPS-induced NF-κB activation in HEK293 cells (IC50 = 2.4 μg/mL). Also inhibits LPS-induced cytokine production and procoagulant effects in PBMCs and HUVECs. Prolongs survival in a mouse septic sh...		TLR
TQ0181	Resatorvid	CLI-095,TAK-242	TNF , TLR , Autophagy , Interleukin
	Resatorvid (TAK-242) is a selective inhibitor of Toll-like receptor 4 (TLR4). Resatorvid binds directly to Cys747 and prevents TLR4 from binding to TIRAP, thereby blocking downstream signaling. Resatorvid has antitumor a...		TNF , TLR , Autophagy , Interleukin
TP1938L	RS09 2TFA (1449566-36-2 free base)	RS09 2TFA 1449566-36-2(free base)	TLR
	RS09 2TFA (1449566-36-2 free base) is a TLR4 agonist. Promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages in vitro. It acts as an adjuvant in vivo and enhances X-15 sp...		TLR
T5354	IRAK4-IN-7	CA-4948	IRAK
	IRAK4-IN-7 (CA-4948) is a selective and potent IRAK4 kinase inhibitor with in vivo activity in a TLR4-induced cytokine release model.		IRAK
T9172	Simufilam dihydrochloride	PTI-125 dihydrochloride	Others
	Simufilam dihydrochloride (PTI-125 dihydrochloride) is a low toxicity, orally active filamin A (FLNA) activator, which can be used for the research of Alzheimer's disease. Simufilam dihydrochloride preferentially binds a...		Others
T35593	Semapimod tetrahydrochloride	CPSI-2364 tetrahydrochloride	TLR , MAPK
	Semapimod tetrahydrochloride (CPSI-2364 tetrahydrochloride) is a synthetic ornithine mitogen-activated protein kinase blocker and pro-inflammatory cytokine production inhibitor that interferes with macrophage and microgl...		TLR , MAPK
T34249	Rabeximod	ROB-803	TLR
	Rabeximod is a potent immunomodulator that reduces the severity of autoimmune diseases in rat models. Rabeximod inhibits arthritis in a time-dependent manner by stimulating TLR2 and TLR4 downstream to block the activatio...		TLR
T39115	ABR-238901		TLR
	ABR-238901 is an oral, active S100A8/A9 blocker that inhibits the interaction of S100A8/A9 with its receptors RAGE(receptor for advanced glycation end products) and TLR4 (toll-like receptor 4). ABR-238901 has potential a...		TLR
T24167	Inflachromene	ICM	Others
	Inflachromene (ICM) is an inhibitor of HMGB1 and HMGB expression with anti-inflammatory activity.Inflachromene reduces seizure severity in a mouse model of epilepsy by inhibiting HMGB1 translocation, inhibits endothelial...		Others
T9570	Enpatoran		TLR
	Enpatoran is an inhibitor of TLR7(IC50 = 11.1 nM) and TLR8(IC50 = 24.1 nM). Enpatoran was found to be inactive against TLR3, TLR4, and TLR9 in vitro and in vivo.		TLR
T12781	RV01		Others
	RV01 is a novel quinoline-substituted analogue of resveratrol that inhibits DNA damage, reduces ethanol-induced acetaldehyde dehydrogenase (ALDH2) mRNA expression, and has hydroxyl radical scavenging activity. rV01 reduc...		Others
T38366	CAY10614	CAY10614
	CAY10614 is a TLR4 antagonist. CAY10614 inhibits lipid A-induced activation of TLR4 (IC50=1.675 μM). CAY10614 also improves survival in LPS-induced shock model mice.
T27090	CRX-526
	CRX-526, a TLR4 antagonist, protects against advanced diabetic nephropathy.
T26707	AZ606	AZ-606,AZ 606
	AZ606 is a potent agonist of TLR4.
T38261	Sparstolonin B
	Sparstolonin B is a chemical compound that functions as a selective antagonist for TLR2 and TLR4, specifically targeting TLR2- and TLR4-mediated inflammatory signaling. This compound demonstrates additional pharmacologic...
T74427	Paridiprubart
	Paridiprubart (NI-0101), a humanized monoclonal antibody targeting TLR4, offers promising research avenues for rheumatoid arthritis [1].
T26708	AZ617	AZ 617,AZ-617
	AZ617 is a potent agonist of TLR4.
T32128	IAXO-101
	IAXO-101 interferes with TLR4/CD14 signals in humans, rats, and mice.
T26626	AN3485 Hydrochloride
	AN3485 Hydrochloride inhibits TLR2-, TLR3-, TLR4- and TLR5-mediated TNF-α, IL-1β and IL-6.
T75223	RDR 02308
	RDR 02308 is a TLR4-MyD88 binding inhibitor that inhibits full-length β-lactamase [1] .
T69626	L6H21
	L6H21 is an inhibitor of the interaction and signaling transduction of LPS-TLR4/MD-2 (myeloid differentiation 2).
T70145	LYRM03
	LYRM03 is an aminopeptidase inhibitor. LYRM03 is also an ubenimex derivative. LYRM03 attenuates LPS-induced acute lung injury in mice by suppressing the TLR4 signaling pathway. LYRM03 effectively attenuates LPS-induced A...
T38619	GSK1795091	CRX-601
	GSK1795091 (CRX-601) is a synthetic TLR4 agonist and immunologic stimulator with demonstrated antitumor activity. It serves as a vaccine adjuvant, enhancing both mucosal and systemic immunity to influenza virus vaccines.
T72412	Antimicrobial agent-5
	Antimicrobial Agent-5 is a potent antimicrobial agent that exhibits exceptional cell selectivity against both Gram-negative and Gram-positive bacteria. It inhibits the interaction between LPS (lipopolysaccharide) and the...
T78561	M62812 free base
	M62812 (free base), a Toll-like receptor 4 (TLR4) signal transduction inhibitor, suppresses activation of endothelial cells and leukocytes and prevents lethal septic shock in mice. It is utilized in sepsis research [1].
T75952	RS 09 TFA
	RS 09 TFA, a TLR4 agonist, promotes NF-κB nuclear translocation and induces the secretion of inflammatory cytokines in RAW264.7 macrophages in vitro. Additionally, as an adjuvant in vivo, RS 09 TFA enhances serum concent...
T73652	Eritoran
	Eritoran, a Toll-like receptor 4 (TLR4) antagonist, effectively protects mice from lethal infections caused by viruses such as the Ebola virus (EBOV) and Marburg virus (MARV). By decreasing granulocytosis levels, Eritora...
T83895	NCI 126224	NSC 126224
	NCI 126224, a toll-like receptor 4 (TLR4) antagonist, demonstrates selective inhibition of nitric oxide (NO) production in RAW 264.7 macrophages, triggered by the TLR4 agonist LPS (IC50 = 0.31 µM), as opposed to minimal ...
T9569	Simufilamum
	Simufilam (PTI-125) is a low toxicity, orally active filamin A ( FLNA ) activator. Simufilam preferentially binds altered FLNA and restores its native conformation, restores receptor and synaptic activities, reduces its ...
T70268	3A-MPLA
	Monophosphoryl lipid A (MPLA) is a natural agonist for the toll-like receptor-4 (TLR4). It is useful as an adjuvant in immunization. MPLA is a safe prophylactic agent and has immunotherapeutic applications. It induces tu...
T35864	T-5342126
	T-5342126 is a toll-like receptor 4 (TLR4) antagonist.1It reduces LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC50= 27.8 μM), as well as decreases LPS-induced IL-8, TNF-α, and IL-6 production in isola...
T70595	Artemisinin B
	Artemisinin B is a drug which may improve spatial memory in dementia patients and alter the levels of inflammatory cytokines in the hippocampus and the cortex. Artemisinin B may inhibit neuroinflammation and exert neurop...
T79304	Semapimod	CPSI-2364,CNI-1493 free base
	Semapimod is an inhibitor of proinflammatory cytokine production, capable of suppressing TNF-α, IL-1β, and IL-6. It hinders TLR4 signaling with an IC50 of approximately 0.3 μM, impedes p38 MAPK, and reduces nitric oxide ...
T60635	Simufilam hydrochloride
	Simufilam (PTI-125) (hydrochloride) is an orally active filamin A (FLNA) activator with low toxicity that can be used in the Alzheimer's disease research. Simufilam (hydrochloride) preferentially binds to altered FLNA an...
T81360	PSMα3 TFA
	PSMα3 TFA is a peptide utilized in directing dendritic cells (DCs) towards a tolerogenic state, pivotal for DC vaccination approaches. It intrudes and recalibrates human monocyte-derived DCs, disrupting maturation trigge...
T37287	Enpatoran hydrochloride
	Enpatoran (M5049) hydrochloride is a potent and orally active dual inhibitor of TLR7/8 with IC50 values of 11.1 nM and 24.1 nM in HEK293 cells, respectively. This compound specifically inhibits TLR7 and TLR8, while showi...

Compounds

TLR4-IN-C34-C2-COOH

T38547

Synonym: TLR4-IN-C34-C2-COOH

TLR4/NF-κB/MAPK-IN-1

T62359

Synonym:

Target:

TLR4-IN-C34-C2-amide-C6-OH

T74383

Synonym:

Target:

Tri(TLR4-IN-C34-C2-amide-PEG1)-amide-C3-COOH

Tri(TLR4-IN-C34-PEG2-amide-PEG1)-amide-C3-COOH

T74388

Synonym:

Target:

Tri(TLR4-IN-C34-C2-amide-C3-amide-PEG1)-amide-C3-COOH

Target: Histone Methyltransferase

Synonym: CLI-095,TAK-242

Target: TNF, TLR, Autophagy, Interleukin

RS09 2TFA (1449566-36-2 free base)

TP1938L

Synonym: RS09 2TFA 1449566-36-2(free base)

Simufilam dihydrochloride

T9172

Synonym: PTI-125 dihydrochloride

Target: Others

Semapimod tetrahydrochloride

T35593

Synonym: CPSI-2364 tetrahydrochloride

Synonym: AZ-606,AZ 606

Synonym: AZ 617,AZ-617

Antimicrobial agent-5

Synonym: CPSI-2364,CNI-1493 free base

Target:

Simufilam hydrochloride

Enpatoran hydrochloride

T37287

Synonym:

Target:

Cat No.	Product Name	Synonyms	Targets
T3765	L-asarinin	(-)-Episesamin	Others
	L-asarinin ((-)-Episesamin) reduces peripheral blood concentration of IL-12 and inhibits the expression of CXCR3 and TLR4, which means Asarinin may have a role on the TLR4 pathway and produce prolongation of allograft he...		Others
TQ0205	Procyanidin B1		TLR
	Procyanidin B1, isolated from commonly eaten fruits, binds to the TLR4/MD-2 complex and has anti-inflammatory activity.		TLR
TN2232	Soyasaponin Ab		NOS , NF-κB , COX
	Soyasaponin Ab may represent a viable candidate for effective vaccine adjuvant, TLR4 receptor dependent pathway may be involved in immune stimulatory effects of soyasaponin Ab.		NOS , NF-κB , COX
TN7235	4-methoxylonchocarpin		TNF , NF-κB
	4-methoxylonchocarpin was isolated from the roots of Abrus precatorius as a potent anti-inflammatory compound. 4-methoxylonchocarpin inhibited NF-κB-activated TNF expression by inhibiting the binding of LPS to TLR4 in ma...		TNF , NF-κB
T5S0167	Atractylenolide I		IL Receptor , TNF , TLR , JAK , STAT
	1. Atractylenolide-I has an anti-inflammatory effect by inhibiting TNF-α and IL-6 production; ameliorates sepsis syndrome, liver and kidney functions by reduction of pro-inflammatory cytokines and LPS. 2. Atractylenolide...		IL Receptor , TNF , TLR , JAK , STAT
TN1936	Mogroside III-E		IL Receptor , TNF , TLR
	Mogroside III-E is a cucurbitane-type compound isolated from Siraitia grosvenorii, has anti-inflammatory activity, it attenuates LPS-induced acute lung injury in mice partly through regulation of the TLR4/MAPK/NF-κB axis...		IL Receptor , TNF , TLR
TN2008	Okanin		NF-κB , TLR
	Okanin shows significant activities on both linoleic acid peroxidation inhibition and DPPH radical scavenging effect.		NF-κB , TLR
T3898	Schaftoside	APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE,Shaftoside	Dynamin , Antioxidant , TLR , MyD88 , Mitochondrial Metabolism , Autophagy
	Schaftoside (APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE) has antioxidant and anticancer activity.
T5740	25(R,S)-Ruscogenin	(25RS)-Ruscogenin	Others , HIF
	25(R,S)-Ruscogenin is a natual product.		Others , HIF
T6S1917	Schisandrol B	Gomisin A,TJN-101,Besigomsin,Gamma-Schisandrin,Schizandrol B,Wuweizi alcohol-B	P450 , Reactive Oxygen Species , Autophagy
	1. Schisandrol B (Besigomsin) may exert neuroprotective effects by attenuating the microglia-mediated neuroinflammatory response via inhibiting the TLR4-mediated NF-κB and MAPKs signaling pathways. 2. Schisandrol B has a...		P450 , Reactive Oxygen Species , Autophagy
TJS1779	Protosappanin A	PTA	NADPH-oxidase , IL Receptor , IκB/IKK , TNF , NF-κB , TLR , ROS , COX , HIV Protease , JAK , NO Synthase , STAT
	Protosappanin A (PTA) has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IÎºB/NF-ÎºB inflammation signal pathway; it exerts anti-neuroinflammatory ...
T3826	Polygalasaponin F		NF-κB , TLR , Akt , PI3K
	Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and reduce the expression of inducible nitric oxide synthases. Po...		NF-κB , TLR , Akt , PI3K
T5S0045	Isofraxidin	6,8-Dimethoxyumbelliferone,Phytodolor	MMP , ERK , p38 MAPK , TLR , COX
	1. Isofraxidin (Phytodolor) protects leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in a p53-independent manner. 2. Isofraxidin has a protective effect against LPS-induced ALI, and the prote...		MMP , ERK , p38 MAPK , TLR , COX
T27281	Eritoran Tetrasodium	B 1287,E 5564,B-1287,E5564,B1287,E-5564
	Eritoran Tetrasodium, a TLR4 receptor antagonist, is used potentially for the treatment of type 2 diabetes.
T38635	Kdo2-Lipid A ammonium		TNF , TLR , Prostaglandin Receptor
	Kdo2-Lipid A ammonium (KLA) is a selective and potent TLR4 agonist, a lipopolysaccharide.Kdo2-Lipid A ammonium induces the release of TNF and PGE2.		TNF , TLR , Prostaglandin Receptor
T27191	D-Mannuronic Acid
	D-Mannuronic Acid is a blocker of the TLR2 and TLR4 downstream signaling pathway. D-Mannuronic Acid effectively inhibits mRNA expression of MyD88 and p65, major subunit of nuclear factor-kappaB.
T37253	Chitohexaose hexahydrochloride
	Chitohexaose hexahydrochloride is a chitosan oligosaccharide compound that possesses anti-inflammatory properties. It exerts its anti-inflammatory effect by binding to the active sites of TLR4, thereby inhibiting inflamm...
T38394	PSMα3
	PSMα3 is a peptide compound that can be utilized to induce tolerance in dendritic cells (DCs) for DC vaccination strategies. It effectively penetrates and modulates human monocyte-derived DCs by modifying the maturation ...
TN3587	Capillarisin		MMP , ERK , IL Receptor , BCL , VEGFR , TNF , NOS , NF-κB , TLR , MAPK , COX , DNA/RNA Synthesis , Prostaglandin Receptor , JNK , STAT
	Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cells, it inhibits cancer cell growth of osteosarcoma cells by ...

Natural Products

L-asarinin

T3765

Synonym: (-)-Episesamin

Target: NOS, NF-κB, COX

4-methoxylonchocarpin

Target: IL Receptor, TNF, TLR, JAK, STAT

Mogroside III-E

TN1936

Synonym:

Target: IL Receptor, TNF, TLR

Synonym: APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE,Shaftoside

Target: Dynamin, Antioxidant, TLR, MyD88, Mitochondrial Metabolism, Autophagy

25(R,S)-Ruscogenin

T5740

Synonym: (25RS)-Ruscogenin

Target: Others, HIF

Schisandrol B

T6S1917

Synonym: Gomisin A,TJN-101,Besigomsin,Gamma-Schisandrin,Schizandrol B,Wuweizi alcohol-B

Target: P450, Reactive Oxygen Species, Autophagy

Protosappanin A

TJS1779

Synonym: PTA

Target: NADPH-oxidase, IL Receptor, IκB/IKK, TNF, NF-κB, TLR, ROS, COX, HIV Protease, JAK, NO Synthase, STAT

Polygalasaponin F

T3826

Synonym:

Target: NF-κB, TLR, Akt, PI3K

Isofraxidin

T5S0045

Synonym: 6,8-Dimethoxyumbelliferone,Phytodolor

Target: MMP, ERK, p38 MAPK, TLR, COX

Eritoran Tetrasodium

T27281

Synonym: B 1287,E 5564,B-1287,E5564,B1287,E-5564

Target:

Kdo2-Lipid A ammonium

T38635

Synonym:

Target: TNF, TLR, Prostaglandin Receptor

Chitohexaose hexahydrochloride

Target: MMP, ERK, IL Receptor, BCL, VEGFR, TNF, NOS, NF-κB, TLR, MAPK, COX, DNA/RNA Synthesis, Prostaglandin Receptor, JNK, STAT

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-02904	TLR4 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	TLR4, also known as TLR-4, is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans...
TMPY-03999	MD2/LY96 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	LY96 (Lymphocyte Antigen 96, also known as ESOP-1) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. This gene encodes a protein that associates with toll-like receptor 4 on the cell su...
TMPY-04389	MAP3K8 Protein, Human, Recombinant (GST)	Human	Baculovirus Insect Cells
	Mitogen-activated protein kinase kinase kinase 8, also known as Cancer Osaka thyroid oncogene, Proto-oncogene c-Cot, Serine/threonine-protein kinase cot, Tumor progression locus 2 and MAP3K8, is a cytoplasm protein that ...
TMPH-02873	RAB10 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bou...
TMPH-01552	IRF1 Protein, Human, Recombinant (GST & His)	Human	Baculovirus Insect Cells
	Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. Regulates transcription of IFN and IFN-inducible genes, host response to viral and bacterial infections,...