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L-asarinin

Catalog No. T3765 CAS 133-05-1

Synonyms: (-)-Episesamin

L-asarinin ((-)-Episesamin) reduces peripheral blood concentration of IL-12 and inhibits the expression of CXCR3 and TLR4, which means Asarinin may have a role on the TLR4 pathway and produce prolongation of allograft heart survival.

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L-asarinin, CAS 133-05-1

Pack Size	Availability	Price/USD	Quantity
20 mg	In stock	$ 140.00
1 mL * 10 mM (in DMSO)	In stock	$ 80.00

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Purity: 98%

Biological Description

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Storage & Solubility Information

Description

Kinase Assay

Samples containing either URB602 (300 μM), MGL (1.4 pM), or both URB602 and MGL are incubated at 37°C for 30 min in assay buffer. At various time points, the reaction is stopped with an equal volume of ice-cold methanol and directly analyzed in positive ionization mode by LC/MS. A SB-CN column (150×2.1 mm i.d., 5 μm) eluted is used with a linear gradient of methanol in water containing 0.25% acetic acid and 5 mM ammonium acetate (from 60% to 100% of methanol in 8 min) at a flow rate of 0.5 mL/min with column temperature at 50°C. Capillary voltage is set at 4 kV and fragmentor voltage is 100V. Nebulizer pressure is set at 60 psi. N2 is used as drying gas at a flow rate of 13 liters/min and a temperature of 350°C. ESI is in the positive mode and a full scan spectrum is acquired from m/z 100 to 600. Extracted ion chromatograms are used to quantify URB602 ([M+H]+, m/z 296)[2].

Synonyms	(-)-Episesamin
Molecular Weight	354.35
Formula	C20H18O6
CAS No.	133-05-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (169.32 mM)

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble

References and Literature

1. Gu J., et al. The effect of Asarinin on Toll-like pathway in rats after cardiac allograft implantation. Transplant Proc. 2015 Mar;47(2):545-8. 2. Bogurcu N., et al. ALCAPs induce mitochondrial apoptosis and activate DNA damage response by generating ROS and inhibiting topoisomerase I enzyme activity in K562 leukemia cell line. Biochem Biophys Res Commun. 2011 Jun 17;409(4):738-44.

Related compound libraries

This product is contained In the following compound libraries：

RO5 Drug-like Natural Product Library Anti-COVID-19 Traditional Chinese Medicine Compound Library Food as Medicine Compound Library NO PAINS Compound Library Bioactive Compounds Library Max Natural Product Library Selected Plant-Sourced Compound Library Chinese Pharmacopoeia Natural Product Library Traditional Chinese Medicine Monomer Library Natural Product Library for HTS

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

L-asarinin 133-05-1 Others L asarinin Episesamin (-)-Episesamin Lasarinin inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.