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Protosappanin A

Catalog No. TJS1779 CAS 102036-28-2

Synonyms: PTA

Protosappanin A (PTA) has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IÎºB/NF-ÎºB inflammation signal pathway; it exerts anti-neuroinflammatory effect by inhibiting JAK2-STAT3 pathway in lipopolysaccharide-induced BV2 microglia. Protosappanin A induces immunosuppression of rats heart transplantation targeting T cells in grafts via NF-kappaB pathway. Protosappanin A and protosappanin B have antimicrobial activity, they show both alone activities and resistance reversal effects of amikacin and gentamicin against MRSA. Protosappanin A shows strong effect against HIV-1 IN with an IC50 value of 12.6 uM.

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Protosappanin A, CAS 102036-28-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 148.00
5 mg	In stock	$ 455.00
10 mg	In stock	$ 672.00
25 mg	In stock	$ 1,060.00
50 mg	In stock	$ 1,430.00
100 mg	In stock	$ 1,920.00
1 mL * 10 mM (in DMSO)	In stock	$ 392.00

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Purity: 100%

Purity: 99.42%

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Description	Protosappanin A (PTA) has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IÎºB/NF-ÎºB inflammation signal pathway; it exerts anti-neuroinflammatory effect by inhibiting JAK2-STAT3 pathway in lipopolysaccharide-induced BV2 microglia. Protosappanin A induces immunosuppression of rats heart transplantation targeting T cells in grafts via NF-kappaB pathway. Protosappanin A and protosappanin B have antimicrobial activity, they show both alone activities and resistance reversal effects of amikacin and gentamicin against MRSA. Protosappanin A shows strong effect against HIV-1 IN with an IC50 value of 12.6 uM.
Targets&IC50	HIV-1 (IN):12.6 uM
In vitro	Protosappanin A (PsA) and Protosappanin B (PsB) were identified from Sappan Lignum extracts. They showed activity against both S. aureus and MRSA with MIC or MIC50 at 64 (PsA) and 128 (PsB) mg/L alone. When they were used in combination with antibiotics, they showed the best synergy with amikacin and gentamicin with MIC50 (mg/L) of amikacin reduced more significantly from 32 to four (with PsA) and eight (with PsB), and the fractional inhibitory concentration index (FICI) ranged between 0.078 and 0.500 (FICI50 = 0.375). Moreover, the resistance of MRSA towards amikacin and gentamicin could be reversed by the Clinical and Laboratory Standards Institute criteria. The combined bactericidal mode could as well be synergy. PsA and PsB showed very low cytotoxicity in comparison with their promising activity against MRSA[1].
Source	Natural Products > Fabaceae > Caesalpinia

Synonyms	PTA
Molecular Weight	272.25
Formula	C15H12O5
CAS No.	102036-28-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 225 mg/mL (826.45 mM)

References and Literature

1. Antimicrobial activity and synergy of antibiotics with two biphenyl compounds, protosappanins A and B from Sappan Lignum against methicillin-resistant Staphylococcus aureus strains. J Pharm Pharmacol. 2015 Oct;67(10):1439-47.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Traditional Chinese Medicine Monomer Library Membrane Protein-targeted Compound Library Anti-Tumor Natural Product Library Anti-Breast Cancer Compound Library Anti-Inflammatory Traditional Chinese Medicine Compound Library Antidepressant Compound Library Cuproptosis Compound Library Anti-Viral Compound Library Bioactive Compounds Library Max

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Keywords

Protosappanin A 102036-28-2 Angiogenesis Apoptosis Chromatin/Epigenetic Immunology/Inflammation JAK/STAT signaling Microbiology/Virology Neuroscience NF-Κb Proteases/Proteasome Stem Cells STAT NADPH-oxidase NO Synthase JAK IL Receptor HIV Protease COX ROS TLR NF-κB TNF IκB/IKK inhibit Inhibitor PTA Janus kinase inhibitor

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