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Isofraxidin

Catalog No. T5S0045 CAS 486-21-5

Synonyms: 6,8-Dimethoxyumbelliferone, Phytodolor

1. Isofraxidin (Phytodolor) protects leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in a p53-independent manner. 2. Isofraxidin has a protective effect against LPS-induced ALI, and the protective effect of Isofraxidin seems to result from the inhibition of COX-2 protein expression in the lung, which regulates the production of PGE2. 3. Isofraxidin possesses significant analgesic and anti-inflammatory activities that may be mediated through the regulation of pro-inflammatory cytokines, TNF-α and the phosphorylation of p38 and ERK1/2.

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Isofraxidin, CAS 486-21-5

Pack Size	Availability	Price/USD
5 mg	In stock	$ 48.00
10 mg	In stock	$ 82.00
25 mg	In stock	$ 168.00
50 mg	In stock	$ 252.00
100 mg	In stock	$ 378.00

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Purity: 99.7%

Purity: 99.65%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Source

Natural Products > Oleaceae > Fraxinus

Synonyms	6,8-Dimethoxyumbelliferone, Phytodolor
Molecular Weight	222.19
Formula	C11H10O5
CAS No.	486-21-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 40 mg/mL(180 mM)

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble

References and Literature

1. Yamazaki T , Tokiwa T . Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits matrix metalloproteinase-7 expression and cell invasion of human hepatoma cells.[J]. Biological & Pharmaceutical Bulletin, 2010, 33(10):1716.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Kinase Inhibitor Library Membrane Protein-targeted Compound Library Anti-Inflammatory Traditional Chinese Medicine Compound Library HIF-1 Signaling Pathway Compound Library Anti-Colorectal Cancer Compound Library Autophagy Compound Library Natural Product Library Anti-Prostate Cancer Compound Library Angiogenesis related Compound Library

Related Products

Related compounds with same targets

Ginkgolide C Glucosamine XL-784 Pimaric acid MMP13-IN-5 Glucosamine sulfate MMP-9-IN-1 Chondroitin sulfate

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Isofraxidin 486-21-5 Immunology/Inflammation MAPK Neuroscience Proteases/Proteasome COX TLR p38 MAPK MMP ERK 6,8-Dimethoxyumbelliferone Cyclooxygenase inhibit hepatoma Matrix metalloproteinases MD-2 COX-2 invasion TLR4 iNOS ERK1/2 MMP-7 cell Phytodolor Inhibitor Toll-like Receptor (TLR) inhibitor

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