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Soyasaponin Ab

Catalog No. TN2232   CAS 118194-13-1

Soyasaponin Ab may represent a viable candidate for effective vaccine adjuvant, TLR4 receptor dependent pathway may be involved in immune stimulatory effects of soyasaponin Ab.

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Soyasaponin Ab Chemical Structure
Soyasaponin Ab, CAS 118194-13-1
Pack Size Availability Price/USD Quantity
1 mg In stock $ 77.00
5 mg In stock $ 165.00
10 mg In stock $ 282.00
25 mg In stock $ 447.00
50 mg In stock $ 659.00
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Purity: 99.79%
Purity: 98.27%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Soyasaponin Ab may represent a viable candidate for effective vaccine adjuvant, TLR4 receptor dependent pathway may be involved in immune stimulatory effects of soyasaponin Ab.
In vitro Soyasaponin Ab inhibited colon shortening, myeloperoxidase activity, the expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), and activation of the transcription factor nuclear factor-κB (NF-κB). Soyasaponin Ab (1, 2, 5, and 10 μM) inhibited the production of NO (IC(50) = 1.6 ± 0.1 μM) and prostaglandin E(2) (IC(50) = 2.0 ± 0.1 ng/mL), the expression of tumor necrosis factor (TNF)-α± (IC(50) = 1.3 ± 0.1 ng/mL), interleukin (IL)-1β (IC(50) = 1.5 ± 0.1 pg/mL), and toll-like receptor (TLR)4, and the phosphorylation of interleukin-1 receptor-associated kinase (IRAK)-1 in LPS-stimulated peritoneal macrophages. Soyasaponin Ab weakly inhibited the phosphorylation of ERK, JNK, and p38. Soyasaponin Ab significantly reduced the binding of Alexa-Fluor-594-conjugated LPS to peritoneal macrophages. Soyasaponin Ab did not affect TLR4 expression or LPS-induced NF-κB activation in TLR4 siRNA-treated peritoneal macrophages (knockdown efficiency of TLR4 > 94%).
Source
Molecular Weight 1437.52
Formula C67H104O33
CAS No. 118194-13-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (69.56 mM)

TargetMolReferences and Literature

1. Lee IA, et al. Soyasaponin Ab ameliorates colitis by inhibiting the binding of lipopolysaccharide (LPS) to Toll-like receptor (TLR)4 on macrophages. J Agric Food Chem. 2011 Dec 28;59(24):13165-72. 2. Yang SH, et al. Soyasaponins Aa and Ab exert an anti-obesity effect in 3T3-L1 adipocytes through downregulation of PPARγ. Phytother Res. 2015 Feb;29(2):281-7.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Pancreatic Cancer Compound Library Natural Product Library for HTS Traditional Chinese Medicine Monomer Library Human Metabolite Library Anti-Cancer Compound Library Bioactive Compounds Library Max Neuronal Signaling Compound Library Bioactive Compound Library Immunology/Inflammation Compound Library Anti-Breast Cancer Compound Library

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Keywords

Soyasaponin Ab 118194-13-1 Immunology/Inflammation Neuroscience NF-Κb NF-κB NOS COX inhibit Inhibitor inhibitor

 

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