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IRAK4-IN-7

Catalog No. T5354 CAS 1801343-74-7

Synonyms: CA-4948

CA-4948 (previously AU-4948) is a selective and potent IRAK4 kinase inhibitor with in vivo activity in a TLR4-induced cytokine release model.

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IRAK4-IN-7, CAS 1801343-74-7

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	CA-4948 (previously AU-4948) is a selective and potent IRAK4 kinase inhibitor with in vivo activity in a TLR4-induced cytokine release model.
In vitro	CA-4948 was previously shown to exhibit dose-dependent efficacy in ABC-DLBCL MYD88-L265P xenograft tumor models using cell lines OCI-LY3 and OCI-LY10[1].
In vivo	CA-4948 has antitumor activity in ABC-type diffuse large B cell lymphoma patient-derived xenograft (PDX) mouse models[2].

Synonyms	CA-4948
Molecular Weight	417.429
Formula	C21H19N7O3
CAS No.	1801343-74-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 13.89 mg/mL (33.28 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Robert N. Booher, et al. Abstract 1168: Efficacy of the IRAK4 inhibitor CA-4948 in patient-derived xenograft models of diffuse large B cell lymphoma. AACR Annual Meeting 2017; April 1-5, 2017; 2. Booher, R.N., Samson, M.E., Xu, G.-X., et al. Abstract 1168: Efficacy of the IRAK4 inhibitor CA-4948 in patient-derived xenograft models of diffuse large B cell lymphoma. Cancer Res. 77(13 Supp), 1168 (2017).

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Anti-Obesity Compound Library Inhibitor Library Immunology/Inflammation Compound Library Drug Repurposing Compound Library Kinase Inhibitor Library Nonsteroidal Anti-Inflammatory Compound Library Anti-Viral Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library

Related Products

Related compounds with same targets

Zimlovisertib IRAK-4 protein kinase inhibitor 2 JH-X-119-01 Thalidomide 4-fluoride IRAK4-IN-20 HS-243 IRAK inhibitor 6 IRAK inhibitor 1

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

IRAK4-IN-7 1801343-74-7 NF-Kb信号通路免疫与炎症 IRAK ABC-type large B cell lymphoma IRAK4 lymphoma DLBCL CA-4948 IRAK4 IN 7 IL-1R associated kinase non-Hodgkin diffuse IRAK-4-IN-7 Interleukin-1 receptor associated kinase Inhibitor IRAK4IN7 inhibit inhibitor

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