Powder: -20°C for 3 years
In solvent: -80°C for 2 years
CA-4948 (previously AU-4948) is a selective and potent IRAK4 kinase inhibitor with in vivo activity in a TLR4-induced cytokine release model.
Description | CA-4948 (previously AU-4948) is a selective and potent IRAK4 kinase inhibitor with in vivo activity in a TLR4-induced cytokine release model. |
In vitro | CA-4948 was previously shown to exhibit dose-dependent efficacy in ABC-DLBCL MYD88-L265P xenograft tumor models using cell lines OCI-LY3 and OCI-LY10[1]. |
In vivo | CA-4948 has antitumor activity in ABC-type diffuse large B cell lymphoma patient-derived xenograft (PDX) mouse models[2]. |
Synonyms | CA-4948 |
Molecular Weight | 417.429 |
Formula | C21H19N7O3 |
CAS No. | 1801343-74-7 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 13.89 mg/mL (33.28 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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IRAK4-IN-7 1801343-74-7 NF-Kb信号通路 免疫与炎症 IRAK ABC-type large B cell lymphoma IRAK4 lymphoma DLBCL CA-4948 IRAK4 IN 7 IL-1R associated kinase non-Hodgkin diffuse IRAK-4-IN-7 Interleukin-1 receptor associated kinase Inhibitor IRAK4IN7 inhibit inhibitor