Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Simufilam dihydrochloride (PTI-125 dihydrochloride) is a low toxicity, orally active filamin A (FLNA) activator, which can be used for the research of Alzheimer's disease. Simufilam dihydrochloride preferentially binds altered FLNA and restores its native conformation, restoring receptor and synaptic activities and reducing its α7nAChR/TLR4 associations and downstream pathologies.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 74.00 | |
5 mg | In stock | $ 153.00 | |
10 mg | In stock | $ 243.00 | |
25 mg | In stock | $ 515.00 | |
50 mg | In stock | $ 669.00 | |
100 mg | In stock | $ 871.00 | |
200 mg | In stock | $ 1,150.00 | |
500 mg | In stock | $ 1,680.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 173.00 |
Description | Simufilam dihydrochloride (PTI-125 dihydrochloride) is a low toxicity, orally active filamin A (FLNA) activator, which can be used for the research of Alzheimer's disease. Simufilam dihydrochloride preferentially binds altered FLNA and restores its native conformation, restoring receptor and synaptic activities and reducing its α7nAChR/TLR4 associations and downstream pathologies. |
In vitro | Simufilam dihydrochloride (1 pM~1 nM) increases NMDA/glycine-induced Arc expression in a dose-dependent manner. Simufilam dihydrochloride (1 nM, 1 hour) largely restores filamin A to its native conformation and effectively normalizes receptor activities in AD frontal cortices. Simufilam dihydrochloride dose-dependently reduces Ab42-induced FLNA coupling to a7nAChR and TLR4 in both Ab42-treated control and AD hippocampus. Simufilam dihydrochloride reduces Ab42's binding affinity for a7nAChR, thereby prevents Ab42's signaling and further accumulation on a7nAChRs. |
In vivo | Simufilam dihydrochloride (22 mg/kg; p.o.) robustly reduces FLNAea7nAChR/TLR4 associations. Simufilam dihydrochloride significantly improves spatial memory. |
Synonyms | PTI-125 dihydrochloride |
Molecular Weight | 332.3 |
Formula | C15H23Cl2N3O |
CAS No. | 2480226-06-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 65 mg/ml (195.61 mM)
You can also refer to dose conversion for different animals. More
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Simufilam dihydrochloride 2480226-06-8 Others PTI-125 Dihydrochloride Simufilam Inhibitor PTI 125 Dihydrochloride PTI-125 inhibit PTI 125 PTI125 Dihydrochloride Simufilam Dihydrochloride PTI125 PTI-125 dihydrochloride inhibitor