Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Mogroside III-E is a cucurbitane-type compound isolated from Siraitia grosvenorii, has anti-inflammatory activity, it attenuates LPS-induced acute lung injury in mice partly through regulation of the TLR4/MAPK/NF-κB axis via AMPK activation. It also has anti-fibrotic activity, it reduces pulmonary fibrosis through Toll-Like receptor 4 pathways.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 77.00 | |
5 mg | In stock | $ 165.00 | |
10 mg | In stock | $ 283.00 | |
25 mg | In stock | $ 478.00 | |
50 mg | In stock | $ 687.00 | |
100 mg | In stock | $ 957.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 297.00 |
Description | Mogroside III-E is a cucurbitane-type compound isolated from Siraitia grosvenorii, has anti-inflammatory activity, it attenuates LPS-induced acute lung injury in mice partly through regulation of the TLR4/MAPK/NF-κB axis via AMPK activation. It also has anti-fibrotic activity, it reduces pulmonary fibrosis through Toll-Like receptor 4 pathways. |
In vitro | MG IIIE elevated the cell viability of HG-induced MPC-5 cells, reduced the concentrations of inflammatory cytokines and decreased the levels of oxidative stress-related markers.?What's more, the apoptosis of podocytes induced by HG was inhibited after MG IIIE intervention, accompanied by the upregulated expression of Bcl-2 and downregulated expression of Bax, cleaved caspase-3 and cleaved caspase-9.?It was also found that MG IIIE could activate the AMPK/SIRT1 signaling, but compound C inhibited this pathway and reversed the inhibitory effects of MG IIIE on inflammation, oxidative stress and apoptosis in HG-stimulated podocytes. |
Source |
Molecular Weight | 963.15 |
Formula | C48H82O19 |
CAS No. | 88901-37-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 9.64 mg/mL (10 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Mogroside III-E 88901-37-5 Apoptosis Immunology/Inflammation TNF IL Receptor TLR inhibit Inhibitor Mogroside IIIE Mogroside III E inhibitor