Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cells, it inhibits cancer cell growth of osteosarcoma cells by inducing apoptosis accompanied with G0/G1-phase cell cycle arrest and loss in mitochondrial membrane potential.Capillarisin has anti-inflammatory activity, can inhibit LPS-induced inflammation by blocking TLR4-mediated NF-κB and MAPKs activation in BV2 microglia. Capillarisin possesses promising anti-hyperalgesic and anti-allodynic effects through the inhibition of various inflammatory pain signaling.
Description | Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cells, it inhibits cancer cell growth of osteosarcoma cells by inducing apoptosis accompanied with G0/G1-phase cell cycle arrest and loss in mitochondrial membrane potential.Capillarisin has anti-inflammatory activity, can inhibit LPS-induced inflammation by blocking TLR4-mediated NF-κB and MAPKs activation in BV2 microglia. Capillarisin possesses promising anti-hyperalgesic and anti-allodynic effects through the inhibition of various inflammatory pain signaling. |
Molecular Weight | 316.26 |
Formula | C16H12O7 |
CAS No. | 56365-38-9 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
( < 1 mg/ml refers to the product slightly soluble or insoluble )
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Capillarisin 56365-38-9 DNA损伤和修复 G蛋白偶联受体 JAK/STAT信号通路 MAPK信号通路 NF-Kb信号通路 蛋白酪氨酸激酶 蛋白酶体 凋亡 干细胞 免疫与炎症 神经科学 细胞周期 血管生成 MAPK JNK MMP IL Receptor NOS NF-κB DNA/RNA Synthesis ERK BCL COX Prostaglandin Receptor STAT VEGFR TNF TLR Inhibitor inhibitor inhibit