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TLR4-IN-C34

Catalog No. T8503   CAS 40592-88-9

TLR4-IN-C34 is an inhibitor of TLR4, and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
TLR4-IN-C34 Chemical Structure
TLR4-IN-C34, CAS 40592-88-9
Pack Size Availability Price/USD Quantity
2 mg In stock $ 38.00
5 mg In stock $ 61.00
10 mg In stock $ 85.00
25 mg In stock $ 133.00
50 mg In stock $ 215.00
100 mg In stock $ 318.00
1 mL * 10 mM (in DMSO) In stock $ 68.00
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Purity: 99.77%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description TLR4-IN-C34 is an inhibitor of TLR4, and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis
In vitro TLR4-IN-C34 reduced systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis.
Animal Research Experimental NEC was induced in 7 8 day old mice .TLR4-IN-C34 was administered via the oral route at a concentration of 1 mg/kg on each morning of the four day model.
Molecular Weight 389.4
Formula C17H27NO9
CAS No. 40592-88-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 9 mg/mL (23.11 mM)

TargetMolReferences and Literature

1. Neal MD, et al. Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors. PLoS One. 2013 Jun 12;8(6):e65779. 2. Adegoke E O , Adeniran S O , Zeng Y , et al. Pharmacological inhibition of TLR4/NF-κB with TLR4-IN-C34 attenuated microcystin-leucine arginine toxicity in bovine Sertoli cells[J]. Journal of Applied Toxicology, 2019.

TargetMolCitations

1. Yi Y, Gao K, Lin P, et al. Staphylococcus aureus-Induced Necroptosis Promotes Mitochondrial Damage in Goat Endometrial Epithelial Cells. Animals. 2022, 12(17): 2218.

Related compound libraries

This product is contained In the following compound libraries:
Immunology/Inflammation Compound Library NO PAINS Compound Library Pyroptosis Compound Library Inhibitor Library Bioactive Compounds Library Max Immuno-Oncology Compound Library Bioactive Compound Library

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Keywords

TLR4-IN-C34 40592-88-9 Immunology/Inflammation TLR TLR4 IN C34 Toll-like Receptor (TLR) Inhibitor TLR4INC34 inhibit TLR-4-IN-C34 inhibitor

 

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