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Search Results for " mif "

Targets

107

Compounds

9

Natural Products

12

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T60850 MIF-IN-2 Others
MIF-IN-2 is a heterocyclic macrophage migration inhibitory factor (MIF) inhibitor with anticancer activity for the study of cancer and autoimmune disorders.CAS 번호13460-73-86-5
T3680 ISO-1 MIF Antagonist,ISO 1 Others
ISO-1 (MIF Antagonist) is an inhibitor of the dopachrome tautomerase activity, blocks the activation of NF-κB and TNF-α secretion from LPS-treated macrophages.
T62344 MIF-IN-3
MIF-IN-3 is an inhibitor of migration inhibitory factor (MIF), which can be used in the study of immunoinflammation-related diseases.
T61218 MIF-IN-5
MIF-IN-5 (compound 1d) is a highly effective and reversible competitive inhibitor of macrophage migration inhibitory factor (MIF), exhibiting an IC 50 of 4.8 μM and a Ki value of 3.3 μM [1].
T60809 MIF-IN-1
MIF-IN-1 (compound 14) is a potent inhibitor of macrophage migration inhibitory factor (MIF) with pIC50 of 6.87. Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine associated with multiple disease...
T69525 MIF degrader MD13
MIF degrader MD13 is involved in protein-protein interactions that play key roles in inflammation and cancer. Current strategies to develop small molecule modulators of MIF functions are mainly restricted to the MIF taut...
T61705 MIF-IN-6
MIF-IN-6 (compound 2d) is an effective inhibitor of macrophage migration inhibitory factor (MIF), exhibiting an IC50 of 1.4 μM and a Ki value of 0.96 μM. MIF-IN-6 effectively reduces MIF-induced ERK phosphorylation and i...
T73676 MIF-1 TFA
MIF-1 TFA (Melanostatin), an intrinsic brain peptide, serves as a powerful allosteric modulator of the dopamine receptor. It plays a crucial role in regulating melanin production and modifies the analgesic efficacy by in...
T76186 Tyr-W-MIF-1
Tyr-W-MIF-1, an opioid tetrapeptide, exhibits both opiate and antiopiate activities, and has been demonstrated to induce analgesia [1] [2] [5].
T63322 MIF-IN-4 hydrochloride
MIF-IN-4 hydrochloride is a potent inhibitor of macrophage mobility inhibitory factor (MIF) with pIC50 values ranging from 5.01-6. Where MIF was originally discovered as a cytokine in the process of inhibiting macrophage...
T7844 4-IPP 4-Iodo-6-phenylpyrimidine Others
4-IPP (4-Iodo-6-phenylpyrimidine) is an irreversible inhibitor of macrophage migration inhibitory factor (MIF)
TP1127L1 Nemifitide acetate(173240-15-8 free base) INN 00835 acetate 5-HT Receptor
Nemifitide acetate(173240-15-8 free base) (INN 00835 acetate) is a synthetic pentapeptide antidepressant with a potential for rapid onset of action. It is a peptide analog of melanocyte-inhibiting factor (MIF).
T60388 MIF098 Others
MIF098 is a macrophage migration inhibitory factor (MIF) antagonist.MIF098, inhibits pulmonary hypertension associated with SLE and inhibits pulmonary smooth muscle cell (PASMC) proliferation and migration.MIF098 may be ...
T16074 Mifobate SR-202 PPAR
Mifobate (SR-202) is a potent and specific antagonist of PPARγ. Mifobate shows antiobesity, antidiabetic and antiatherosclerotic effects[1].
T23372 SMIFH2 Others
SMIFH2 is formin homology 2 (FH2) domains inhibitor.
T71973 Gilteritinib hemifumarate ASP2215 hemifumarate FLT , TAM Receptor
Gilteritinib hemifumarate (ASP2215 hemifumarate) is a potent ATP-competitive dual FLT3 (IC50: 0.29 nM) and AXL (IC50: 0.73 nM) inhibitor for the treatment of relapsed or refractory FLT3 mutant AML.
T1492 Gemifloxacin mesylate LB-20304a,SB-265805S,Gemifloxacin mesylate DNA gyrase , Topoisomerase , Antibacterial
Gemifloxacin mesylate (Gemifloxacin mesylate) inhibits activities of DNA gyrase and topoisomerase IV, thereby inhibiting DNA replication and eventually bacterial growth. Gemifloxacin Mesylate is the mesylate salt form of...
T6381 Amifostine trihydrate Ethyol trihydrate,WR2721,Amifostine Others , HIF/HIF Prolyl-Hydroxylase
Amifostine trihydrate (WR2721) is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.
T8623 TMIFRY8XAG 1,1'-(4-CHLOROBUTYLIDENE)BIS(4-FLUOROBENZENE),4-oxo-1,4-dihydroquinoline-2-carboxylic acid Others
TMIFRY8XAG (4-oxo-1,4-dihydroquinoline-2-carboxylic acid) is a derivative of Zerumbone with potential anti-tumor effects towards HeLa cancer cells.
T4497 Amifampridine 3,4-Pyridinediamine,Pyridine-3,4-Diamine,3,4-Diaminopyridine Others
Amifampridine (3,4-Diaminopyridine) is predominantly in the treatment of a number of rare muscle diseases. Amifampridine works by blocking potassium channel efflux in nerve terminals so that action potential duration is ...
T17254 Amifloxacin Win49375 Antibacterial
Amifloxacin (Win49375) is a synthetic antibacterial compound and showed moderate activity against Staphylococcus aureus, with MICs of less than or equal to 2 micrograms/ml.
TQ0133 Amifostine thiol dihydrochloride WR 1065 p53
Amifostine thiol dihydrochloride (WR 1065) can activate p53 through a JNK-dependent signaling pathway. It also protects normal tissues from the toxic effects of certain cancer drugs.
T2065 Bioymifi DR5 Activator Apoptosis , TNF
Bioymifi (DR5 Activator) is a novel and potent small-molecule activator of the TRAIL receptor DR5 in human cancer cells.
T23536 Xamoterol hemifumarate ICI 118587 hemifumarate,Corwin hemifumarate Adrenergic Receptor
Xamoterol hemifumarate is a potent and selective β1-adrenoceptor agonist.Xamoterol hemifumarate is a potential compound for the study of the relationship between cardiac arrhythmias and β1-adrenergic stimulation with IKr...
T4640 Parimifasor LYC30937 Others
Parimifasor (LYC30937) is an immunomodulator, with anti-inflammatory activity.
T33876L1 Panomifene TFA Panomifene TFA(77599-17-8 Free base),EGIS5650 TFA,GYKl13504 TFA Estrogen/progestogen Receptor
Panomifene TFA(GYKl13504 TFA) is a small molecule antagonist of ERs with anticancer activity that can be used to study breast cancer and musculoskeletal diseases.
T68100 Mifentidine DA 4577 Histamine Receptor
Mifentidine (DA 4577) is an orally available H2 receptor antagonist for the study of gastric emptying and experimental gastric and duodenal ulcers.
T7308 Nomifensine NOMIFENSINE MALEATE,(±)-Nomifensin Dopamine Receptor
Nomifensine ((±)-Nomifensin) is a norepinephrine-dopamine reuptake inhibitor that prevents dopamine reuptake into synaptosomes.
T67816 Alamifovir PM
Alamifovir PM is an analogue of Alamifovir, an HBV-specific antiviral compound.
T7282 Tenofovir alafenamide hemifumarate GS-7340 (hemifumarate),Tenofovir alafenamide fumarate HIV Protease , Reverse Transcriptase
Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) is an oral phosphonoamidate prodrug of the HIV reverse transcriptase nucleotide inhibitor tenofovir (TFV)
T20953 Lumiflavine Lumilactoflavin,Lumiflavin Others
Lumiflavine (Lumilactoflavin) inhibits riboflavin uptake. It is produced by the photolysis of vitamin B2.
T8589 (±)-Amiflamine 4-(dimethylamino)-alpha,Amiflamine,2-dimethylphenethylamine MAO , Monoamine Oxidase
(±)-Amiflamine (2-dimethylphenethylamine) is an inhibitor of reversible MAO-A.
T13385 Zamifenacin fumarate UK-76654 fumarate AChR
Zamifenacin fumarate (UK-76654 fumarate) is a potent and gut-selective antagonist of muscarinic M3 receptor.
T37538 Amifostine thiol
Amifostine thiol (WR-1065), the active metabolite of cytoprotector Amifostine, serves as a cytoprotective agent possessing radioprotective properties. It activates p53 via a JNK-dependent signaling pathway[1][2][3].
T3289 Amifostine Ethyol,WR2721,Gammaphos Others , HIF/HIF Prolyl-Hydroxylase
Amifostine (Ethyol) anhydrous is a cytoprotective agent, acts as a free radical scavenging activity.
T21979 P32/98 (hemifumarate)
P32/98 hemifumarateis a potent inhibitor of dipeptidyl peptidase IV with a K i value of 130 nM. P32/98 hemifumarate improves glucose tolerance, insulin sensitivity and β-cell responsiveness in fatty Zucker rat model. P32...
T39520 Vamifeport VIT-2763 Ferroptosis
Vamifeport (VIT-2763) is a novel orally active inhibitor that targets iron transport proteins and reduces markers of hemolysis in the SCD Townes model.VIT-2763 improves anemia and erythropoiesis, ameliorates vascular inf...
T7070 Nomifensine maleate Nomifensine (maleate),(±)-Nomifensine maleat Dopamine Receptor
Nomifensine maleate (Nomifensine (maleate)) is a selective inhibitor of dopamine uptake. Nomifensine maleate is used in adult attention deficit disorder.
T33876L Panomifene HCl EGIS5650 HCl,GYKI 13504 HCl,Panomifene HCl(77599-17-8 Free base),EGIS 5650 HCl HER
Panomifene HCl is a selective anti-estrogenic compound with antitumor activity for the treatment of breast cancer.
T27322 Fispemifene HM-101,HM 101,HM101 Others
Fispemifene (HM-101) is an estrogen receptor modulator (SERM) used to treat genitourinary syndromes and vaginal atrophy.
T0104 Umifenovir hydrochloride Arbidol hydrochloride,Arbidol HCl SARS-CoV , Influenza Virus
Umifenovir hydrochloride (Arbidol HCl) , an broad-spectrum antiviral chemical agent, can inhibit cell invade of enveloped viruses by blocking viral fusion with host cell membrane.
T1102 Mifepristone C-1073,RU486,RU 38486 Glucocorticoid Receptor , Estrogen/progestogen Receptor , Progesterone Receptor , NO Synthase , Autophagy
Mifepristone (C-1073) is a Progestin Antagonist. The mechanism of action of mifepristone is as a Progestational Hormone Receptor Antagonist.
T1520 Aliskiren hemifumarate CGP 60536,SPP 100,CGP60536B RAAS , Autophagy
Aliskiren hemifumarate (CGP60536B) is an orally active nonpeptide renin inhibitor with antihypertensive activity.
T6241 Quetiapine hemifumarate Quetiapine Fumarate,ICI-204636 Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor
Quetiapine hemifumarate (ICI-204636), an atypical antipsychotic, is used in the treatment of bipolar I mania, schizophrenia, bipolar II depression, bipolar I depression.
TP1127 Nemifitide diTFA INN 00835 diTFA 5-HT Receptor
Nemifitide diTFA (INN 00835 diTFA) is a synthetic pentapeptide, a peptide like melanocyte suppressor factor (MIF) that can cross the blood-brain barrier and has potent antidepressant activity.
T63169 MIF2-IN-1
MIF2-IN-1 (compound 5d) is a potent MIF2 tautomerase inhibitor (IC50: 1.0 μM). MIF2-IN-1 inhibits the proliferation of non-small cell lung cancer cells by arresting the cell cycle through the MAPK pathway. MIF2-IN-1 has ...
T25608 Lamifiban trifluoroacetate Lamifiban trifluoroacetate salt
Lamifiban trifluoroacetate is an antagonist of the nonpeptide platelet fibrinogen receptor (GPIIb/IIIa).
T20662 Gemifloxacin SB-265805,SB 265805,SB265805
Gemifloxacin is a fluoronaphthyridone with strong antibacterial effect.
T4497L Amifampridine phosphate BRN0110232,3,6-DAP,SC10,BRN 0110232,BRN-0110232,NSC 521760
Amifampridine is mainly used to treat many rare muscle diseases. In the United States, aminopyridine is being studied for the treatment of Lambert-Eaton myasmus syndrome (LEMS). Amifampridine is also used to treat many c...
T12329 Ospemifene D4 FC-1271a D4 Estrogen/progestogen Receptor
Ospemifene D4 is a deuterium labeled Ospemifene. Ospemifene is a selective and orally active modulator of estrogen receptor.

Compounds

MIF-IN-2
T60850
Synonym:
Target: Others
ISO-1
T3680
Synonym: MIF Antagonist,ISO 1
Target: Others
MIF-IN-3
T62344
Synonym:
Target:
MIF-IN-5
T61218
Synonym:
Target:
MIF-IN-1
T60809
Synonym:
Target:
MIF degrader MD13
T69525
Synonym:
Target:
MIF-IN-6
T61705
Synonym:
Target:
MIF-1 TFA
T73676
Synonym:
Target:
Tyr-W-MIF-1
T76186
Synonym:
Target:
MIF-IN-4 hydrochloride
T63322
Synonym:
Target:
4-IPP
T7844
Synonym: 4-Iodo-6-phenylpyrimidine
Target: Others
Nemifitide acetate(173240-15-8 free base)
TP1127L1
Synonym: INN 00835 acetate
Target: 5-HT Receptor
MIF098
T60388
Synonym:
Target: Others
Mifobate
T16074
Synonym: SR-202
Target: PPAR
SMIFH2
T23372
Synonym:
Target: Others
Gilteritinib hemifumarate
T71973
Synonym: ASP2215 hemifumarate
Target: FLT, TAM Receptor
Gemifloxacin mesylate
T1492
Synonym: LB-20304a,SB-265805S,Gemifloxacin mesylate
Target: DNA gyrase, Topoisomerase, Antibacterial
Amifostine trihydrate
T6381
Synonym: Ethyol trihydrate,WR2721,Amifostine
Target: Others, HIF/HIF Prolyl-Hydroxylase
TMIFRY8XAG
T8623
Synonym: 1,1'-(4-CHLOROBUTYLIDENE)BIS(4-FLUOROBENZENE),4-oxo-1,4-dihydroquinoline-2-carboxylic acid
Target: Others
Amifampridine
T4497
Synonym: 3,4-Pyridinediamine,Pyridine-3,4-Diamine,3,4-Diaminopyridine
Target: Others
Amifloxacin
T17254
Synonym: Win49375
Target: Antibacterial
Amifostine thiol dihydrochloride
TQ0133
Synonym: WR 1065
Target: p53
Bioymifi
T2065
Synonym: DR5 Activator
Target: Apoptosis, TNF
Xamoterol hemifumarate
T23536
Synonym: ICI 118587 hemifumarate,Corwin hemifumarate
Target: Adrenergic Receptor
Parimifasor
T4640
Synonym: LYC30937
Target: Others
Panomifene TFA
T33876L1
Synonym: Panomifene TFA(77599-17-8 Free base),EGIS5650 TFA,GYKl13504 TFA
Target: Estrogen/progestogen Receptor
Mifentidine
T68100
Synonym: DA 4577
Target: Histamine Receptor
Nomifensine
T7308
Synonym: NOMIFENSINE MALEATE,(±)-Nomifensin
Target: Dopamine Receptor
Alamifovir PM
T67816
Synonym:
Target:
Tenofovir alafenamide hemifumarate
T7282
Synonym: GS-7340 (hemifumarate),Tenofovir alafenamide fumarate
Target: HIV Protease, Reverse Transcriptase
Lumiflavine
T20953
Synonym: Lumilactoflavin,Lumiflavin
Target: Others
(±)-Amiflamine
T8589
Synonym: 4-(dimethylamino)-alpha,Amiflamine,2-dimethylphenethylamine
Target: MAO, Monoamine Oxidase
Zamifenacin fumarate
T13385
Synonym: UK-76654 fumarate
Target: AChR
Amifostine thiol
T37538
Synonym:
Target:
Amifostine
T3289
Synonym: Ethyol,WR2721,Gammaphos
Target: Others, HIF/HIF Prolyl-Hydroxylase
P32/98 (hemifumarate)
T21979
Synonym:
Target:
Vamifeport
T39520
Synonym: VIT-2763
Target: Ferroptosis
Nomifensine maleate
T7070
Synonym: Nomifensine (maleate),(±)-Nomifensine maleat
Target: Dopamine Receptor
Panomifene HCl
T33876L
Synonym: EGIS5650 HCl,GYKI 13504 HCl,Panomifene HCl(77599-17-8 Free base),EGIS 5650 HCl
Target: HER
Fispemifene
T27322
Synonym: HM-101,HM 101,HM101
Target: Others
Umifenovir hydrochloride
T0104
Synonym: Arbidol hydrochloride,Arbidol HCl
Target: SARS-CoV, Influenza Virus
Mifepristone
T1102
Synonym: C-1073,RU486,RU 38486
Target: Glucocorticoid Receptor, Estrogen/progestogen Receptor, Progesterone Receptor, NO Synthase, Autophagy
Aliskiren hemifumarate
T1520
Synonym: CGP 60536,SPP 100,CGP60536B
Target: RAAS, Autophagy
Quetiapine hemifumarate
T6241
Synonym: Quetiapine Fumarate,ICI-204636
Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor
Nemifitide diTFA
TP1127
Synonym: INN 00835 diTFA
Target: 5-HT Receptor
MIF2-IN-1
T63169
Synonym:
Target:
Lamifiban trifluoroacetate
T25608
Synonym: Lamifiban trifluoroacetate salt
Target:
Gemifloxacin
T20662
Synonym: SB-265805,SB 265805,SB265805
Target:
Amifampridine phosphate
T4497L
Synonym: BRN0110232,3,6-DAP,SC10,BRN 0110232,BRN-0110232,NSC 521760
Target:
Ospemifene D4
T12329
Synonym: FC-1271a D4
Target: Estrogen/progestogen Receptor
1 2 3
Cat No. Product Name Synonyms Targets
TN6730 Epoxyazadiradione NF-κB
Epoxyazadiradione is an extract from Neem (Azadirachta indica) plant and may induce mitochondrial apoptosis and inhibition of NF-kB in human cervical cancer cells.
T3383 Cimifugin Cimitin Others
Cimifugin (Cimitin) inhibits NO production induced by lipopolysaccharide in macrophage cell line RAW 264.7 and for 1, 1-diphenyl-2-picrylhydrazyl free-radical scavenging activity in cell-free bioassay system.
T3805 Prim-O-glucosylcimifugin Cimifugin beta-D-glucopyranoside,Cimifugin 7-glucoside TNF , COX , JAK , NO Synthase
Prim-O-glucosylcimifugin (Cimifugin 7-glucoside) can inhibit the proliferation of SMC(smooth muscle cell) stimulated by TNF-alpha, increase the proportion of G0/G1 phase.
TN3812 Dehydrovomifoliol AChR
Dehydrovomifoliol could be a marker of Polish heather honey. Dehydrovomifoliol exhibits moderate acetylcholinesterase (AChE) inhibitory activities. Dehydrovomifoliol shows significant cytotoxic activities against three h...
TN1496 Cimifugin 4'-O-β-D-glucopyranoside Cimifugin 4'-O-beta-D-glucopyranoside Others
Cimifugin 4'-O-beta-D-glucopyranoside is a natural product
TN2095 Pomiferin NOS , NF-κB , PDE
Pomiferin is a natural product inhibitor of carbonic anhydrase I and II isoenzymes. It has anticancer, antibacterial and antidiabetic properties. Pomiferin has anti-inflammatory and neuroprotective activities.
T8204 Gummiferin Others
Gummiferin is a natural product for research related to life sciences. The catalog number is T8204 and the CAS number is 33286-30-5.
T83532 (Rac)-Dehydrovomifoliol PBI 344
(Rac)-Dehydrovomifoliol (PBI 344), a bisnorsesquiterpene, is present in Euphorbia peplus [1].
TN5250 Vomifoliol VEGFR , NF-κB , HIF
Vomifoliol is most likely the immediate precursor of dehydrovomifoliol, because of the organism converted abscisic acid (ABA), to dehydrovomifoliol as the major metabolise, and a cell-free extract exhibits vomifoliol deh...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-05176 AMH Protein, Human, Recombinant (His) Human HEK293 Cells
Anti-Mullerian hormone (AMH), a member of the TGF-beta superfamily, is produced by granulosa cells (GCs) of preantral and small antral follicles and plays a role in regulating the recruitment of primordial follicles and ...
TMPY-01357 S100A9 Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
S100A9 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 14.6 kDa and the accession number is P06702.
TMPY-01356 S100A8 Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
S100A8 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 12.2 kDa and the accession number is P05109.
TMPY-02342 MIF Protein, Mouse, Recombinant Mouse E. coli
MIF Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 12.5 kDa and the accession number is P34884.
TMPY-02095 MIF Protein, Human, Recombinant (His) Human HEK293 Cells
MIF Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 13.8 kDa and the accession number is P14174.
TMPY-02145 MIF Protein, Mouse, Recombinant (His) Mouse HEK293 Cells
MIF Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 13.8 kDa and the accession number is P34884.
TMPY-01330 S100A9 Protein, Human, Recombinant Human E. coli
S100A9 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 26 and 13 kDa and the accession number is P06702.
TMPK-01257 DDT Proten, Canine, Recombinant (His) Canine E. coli
D-dopachrome tautomerase (D-DT) is a newly described cytokine and a member of the macrophage migration inhibitory factor (MIF) protein superfamily.The D-DT protein also is present in most tissues and circulates in serum ...
TMPK-00864 DDT Protein, Human, Recombinant (His) Human E. coli
D-dopachrome tautomerase (D-DT) is a newly described cytokine and a member of the macrophage migration inhibitory factor (MIF) protein superfamily.The D-DT protein also is present in most tissues and circulates in serum ...
TMPK-00722 DDT Protein, Mouse, Recombinant (His) Mouse E. coli
D-dopachrome tautomerase (D-DT) is a newly described cytokine and a member of the macrophage migration inhibitory factor (MIF) protein superfamily.The D-DT protein also is present in most tissues and circulates in serum ...
TMPK-01307 DDT Protein, Cynomolgus, Recombinant (His) Cynomolgus E. coli
D-dopachrome tautomerase (D-DT) is a newly described cytokine and a member of the macrophage migration inhibitory factor (MIF) protein superfamily.The D-DT protein also is present in most tissues and circulates in serum ...
TMPJ-01037 CXCR4 Protein, Human, Recombinant (hFc) Human HEK293 Cells
C-X-C chemokine receptor type 4 (CXCR4) is an alpha-chemokine receptor specific for stromal-derived-factor-1 (SDF-1 also called CXCL12), a molecule endowed with potent chemotactic activity for lymphocytes. This receptor ...
TargetMol