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Umifenovir hydrochloride

Catalog No. T0104 CAS 131707-23-8

Synonyms: Arbidol hydrochloride, Arbidol HCl

Umifenovir hydrochloride (Arbidol HCl) , an broad-spectrum antiviral chemical agent, can inhibit cell invade of enveloped viruses by blocking viral fusion with host cell membrane.

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Umifenovir hydrochloride Chemical Structure

Umifenovir hydrochloride, CAS 131707-23-8

Pack Size	Availability	Price/USD
10 mg	In stock	$ 50.00
25 mg	In stock	$ 86.00
50 mg	In stock	$ 145.00
100 mg	In stock	$ 230.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.88%

Purity: 99.85%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Umifenovir hydrochloride (Arbidol HCl) , an broad-spectrum antiviral chemical agent, can inhibit cell invade of enveloped viruses by blocking viral fusion with host cell membrane.
Targets&IC50	RNA viruses(FLU-A, RSV, HRV 14 and CVB3, enveloped and non-enveloped):2.7-13.8 microg/ml
In vitro	Arbidol inhibits the cell entry of HCV pseudoparticles of genotypes 1a, 1b, and 2a in a dose-dependent fashion. Arbidol also displays a dose-dependent inhibition of HCV membrane fusion, as assayed by using HCV pseudoparticles (HCVpp) and fluorescent liposomes. [1] Arbidol is found to present potent inhibitory activity against enveloped and non-enveloped RNA viruses, including FLU-A, RSV, HRV 14 and CVB3 when added before, during, or after viral infection, with IC50 ranging from 2.7 to 13.8 mg/mL. Arbidol shows selective antiviral activity against AdV-7, a DNA virus, only when added after infection (therapeutic index (TI) = 5.5). [2] Arbidol induces changes to viral mRNA synthesis of the PB2, PA, NP, NA, and NS genes in MDCK cultures infected with influenza A/PR/8/34. [3] Arbidol interacts and modifies the physicochemical properties of the phospholipids in the membrane, having a significant effect on negatively charged phospholipids but a minor one on zwitterionic phospholipids. Arbidol is located at the interface of the membrane, participates in hydrogen bonding either with water or the phospholipid or both, and decreases the hydrogen bonding network of the phospholipids giving place to a phospholipid phase similar to the dehydrated solid one. [4] Arbidol is found to have potent inhibitory activity against HTNV when added in vitro before or after viral infection, with IC50 of 0.9 mg/mL and 1.2 mg/mL, respectively. [5]

Synonyms	Arbidol hydrochloride, Arbidol HCl
Molecular Weight	513.88
Formula	C22H25BrN2O3S·HCl
CAS No.	131707-23-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 21 mg/mL (40.9 mM)

DMSO: 95 mg/mL (184.9 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Pécheur EI, et al. Biochemistry, 2007, 46(20), 6050-6059. 2. Shi L, et al. Arch Virol, 2007, 152(8), 1447-1455. 3. Brooks MJ, et al. J Med Virol, 2012, 84(1), 170-181. 4. Villalaín J, et al. J Phys Chem B. 2010 Jul 1;114(25):8544-54. 5. Deng HY, et al. Acta Pharmacol Sin, 2009, 30(7), 12015-1024. 6. Li J, Hu Y, Yuan Y, et al. Repurposing of Antazoline Hydrochloride as an Inhibitor of Hepatitis B Virus DNA Secretion[J]. Virologica Sinica. 2020: 1-9.

Citations

1. Nicholson M W, Huang C Y, Wang J Y, et al. Cardio-and Neurotoxicity of Selected Anti-COVID-19 Drugs. Pharmaceuticals. 2022, 15(6): 765 2. Li J, Hu Y, Yuan Y, et al Repurposing of Antazoline Hydrochloride as an Inhibitor of Hepatitis B Virus DNA Secretion. Virologica Sinica. 2020: 1-9

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Drug Repurposing Compound Library Target-Focused Phenotypic Screening Library Anti-Viral Compound Library Clinical Compound Library Anti-Infection Compound Library FDA-Approved & Pharmacopeia Drug Library Anti-COVID-19 Compound Library Approved Drug Library Bioactive Compounds Library Max

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Keywords

Umifenovir hydrochloride 131707-23-8 Microbiology/Virology SARS-CoV Influenza Virus SARS coronavirus inflammatory fusion Arbidol hydrochloride Arbidol HCl Arbidol Hydrochloride Inhibitor enveloped oral virus inhibit Umifenovir Hydrochloride Umifenovir inhibitor

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