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Pomiferin

Catalog No. TN2095 CAS 572-03-2

Pomiferin is a natural product inhibitor of Carbonic Anhydrase I and II isoenzymes. It has anticancer, Antibacterial and antidiabetic properties. Pomiferin has anti-inflammatory and neuroprotective activities.

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Pomiferin, CAS 572-03-2

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Purity: 98%

Biological Description

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Description	Pomiferin is a natural product inhibitor of carbonic anhydrase I and II isoenzymes. It has anticancer, antibacterial and antidiabetic properties. Pomiferin has anti-inflammatory and neuroprotective activities.
Targets&IC50	mTOR:6.2 μM (IC50), HDAC:1.05 μM (IC50)
In vitro	The two isoflavones were effective in enhancing the activity of NSAID activated gene (NAG-1) at 2.5 pg/mL (1.5-1.8 fold increase) and inhibiting iNOS and NF-κB activity with IC50 values in the range of 6-13 μg/mL. Pomiferin also inhibited intracellular oxidative stress with IC50 of 3.3 μg/mL, while osajin did not show any effect. The extract activated NAG-1 and inhibited iNOS and oxidative stress without affecting NF-κB[1]

Molecular Weight	420.45
Formula	C25H24O6
CAS No.	572-03-2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Potential of Horse Apple Isoflavones in Targeting Inflammation and Tau Protein Fibrillization.Nat Prod Commun. 2015 Sep;10(9):1577-80.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Pomiferin 572-03-2 Immunology/Inflammation Metabolism NF-Κb PDE NF-κB NOS Inhibitor inhibitor inhibit

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