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Quetiapine hemifumarate

Catalog No. T6241 CAS 111974-72-2

Synonyms: Quetiapine Fumarate, ICI-204636

Quetiapine hemifumarate (ICI-204636), an atypical antipsychotic, is used in the treatment of bipolar I mania, schizophrenia, bipolar II depression, bipolar I depression.

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Quetiapine hemifumarate Chemical Structure

Quetiapine hemifumarate, CAS 111974-72-2

Pack Size	Availability	Price/USD
200 mg	In stock	$ 30.00
500 mg	In stock	$ 46.00
1 g	In stock	$ 48.00
1 mL * 10 mM (in DMSO)	In stock	$ 30.00

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Purity: 100%

Purity: 97.63%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Quetiapine hemifumarate (ICI-204636), an atypical antipsychotic, is used in the treatment of bipolar I mania, schizophrenia, bipolar II depression, bipolar I depression.
In vitro	Quetiapine alters the neurotransmitter norepinephrine in the brain's limbic system and the expression of c-fos. It also exhibits antipsychotic activity, diminishing the tendency to induce extrapyramidal symptoms and persistently increase prolactin levels. Its effectiveness in behavioral and biochemical assays mirrors that of clozapine, suggesting it may possess neuroprotective properties.
In vivo	Quetiapine has an affinity for dopamine-2 receptors similar to that of clozapine, and it exhibits comparable affinity for various neurotransmitter receptors, including serotonin, histamine, dopamine, and adrenergic receptors.
Kinase Assay	CDK activity assays: CDK assays for IC50 determinations and kinetic evaluation are performed in 96-well filter plates. All CDK-cyclin kinase complexes are expressed in insect cells through baculovirus infection and purified. The substrate for the assays is a fragment (amino acids 792–928) of pRb fused to GST (GST?RB-Cterm). The total reaction volume is 0.1 mL containing a final concentration of 20 mM Tris-HCl, pH 7.4, 50 mM NaCl, 1 mM dithiothreitol, 10 mM MgCl2 25 μM ATP (for CDK4-cyclin D1, CDK6-cyclin D2, and CDK6-cyclin D3) containing 0.25 μCi of [γ-32P]ATP, 20 ng of enzyme, 1 μg of GST?RB-Cterm, and appropriate dilutions of inhibitor. All components except the [γ-32P]ATP are added to the wells, and placed on a plate mixer for 2 min. The reaction is started by adding the [γ-32P]ATP, and incubated at 25℃ for 15 min. The reaction is terminated by addition of 0.1 mL of 20% trichloroacetic acid, and the plate is kept at 4?℃ for at least 1 hr to allow the substrate to precipitate. The wells are then washed five times with 0.2 mL of 10% trichloroacetic acid, and radioactive incorporation is determined with a β plate counter.

Synonyms	Quetiapine Fumarate, ICI-204636
Molecular Weight	883.09
Formula	C46H54N6O8S2
CAS No.	111974-72-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 22.1 mg/mL (50 mM)

References and Literature

1. Nemeroff CB, et al. J Clin Psychiatry, 2002, 63 Suppl 13, 5-11. 2. Xu H, et al. Hippocampus, 2006, 16(6), 551-559. 3. Kessler RM, et al. Neuropsychopharmacology, 2006, 31(9), 1991-2001. 4. Luo C, et al. Brain Res, 2005, 1063(1), 32-39. 5. Peters JL, et al. Acta Radiol. 1993 Sep;34(5):510-6.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Inhibitor Library Anti-Neurodegenerative Disease Compound Library Membrane Protein-targeted Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library Drug Repurposing Compound Library GPCR Compound Library FDA-Approved Drug Library Clinical Compound Library

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Keywords

Quetiapine hemifumarate 111974-72-2 GPCR/G Protein Neuroscience 5-HT Receptor Dopamine Receptor Adrenergic Receptor Quetiapine Hemifumarate 5-hydroxytryptamine Receptor Inhibitor Quetiapine anxiolytic inhibit Antidepressant 5-HT2A Quetiapine Fumarate 5-HT1A Serotonin Receptor 5-HT2C ICI204636 ICI-204636 ICI 204636 inhibitor

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