store at low temperature,keep away from direct sunlight,keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Nemifitide diTFA (INN 00835 diTFA) is a synthetic pentapeptide, a peptide like melanocyte suppressor factor (MIF) that can cross the blood-brain barrier and has potent antidepressant activity.
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Description | Nemifitide diTFA (INN 00835 diTFA) is a synthetic pentapeptide, a peptide like melanocyte suppressor factor (MIF) that can cross the blood-brain barrier and has potent antidepressant activity. |
In vitro | Nemifitide diTFA (INN 00835 diTFA) and its active metabolite (M1) bind to several receptors, including the 5-HT2A, 5-HT2C, melanocortin MC4, MC5, and bombesin, at micromolar concentrations[2]. |
In vivo | Administered intraperitoneally at a dose of 0.3 mg/kg daily for 14 days, Nemifitide diTFA (INN 00835 diTFA) significantly increases swimming behavior in the FSL rats after just 5 days of treatment, and this effect has a long-lasting duration[2]. Moreover, across a range of doses (0.0125-15.0 mg/kg), Nemifitide diTFA demonstrates a significant increase in swimming behavior in FSL rats at both low (0.025-0.3 mg/kg) and high (3.0-15.0 mg/kg) doses, but not at intermediate (0.4-2.4 mg/kg) doses[3]. |
Synonyms | INN 00835 diTFA |
Molecular Weight | 922.8 |
Formula | C37H45F7N10O10 |
CAS No. | 204992-09-6 |
store at low temperature,keep away from direct sunlight,keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 200 mg/mL (216.73 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Nemifitide diTFA 204992-09-6 GPCR/G Protein Neuroscience 5-HT Receptor INN-00835 Nemifitide INN 00835 diTFA INN 00835 INN00835 inhibitor inhibit