Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) is an oral phosphonoamidate prodrug of the HIV reverse transcriptase nucleotide inhibitor tenofovir (TFV)
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 39.00 | |
10 mg | In stock | $ 55.00 | |
25 mg | In stock | $ 86.00 | |
50 mg | In stock | $ 113.00 | |
100 mg | In stock | $ 155.00 | |
500 mg | In stock | $ 389.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 46.00 |
Description | Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) is an oral phosphonoamidate prodrug of the HIV reverse transcriptase nucleotide inhibitor tenofovir (TFV) |
In vitro | Tenofovir alafenamide fumarate (TAF) is an oral phosphonoamidate prodrug of the HIV reverse transcriptase nucleotide inhibitor tenofovir (TFV).?Overexpression of CatA or liver carboxylesterase 1 (Ces1) in HEK293T cells increased intracellular TAF hydrolysis 2- and 5-fold, respectively.?Knockdown of CatA expression with RNA interference (RNAi) in HeLa cells reduced intracellular TAF metabolism 5-fold.?Additionally, the anti-HIV activity and the rate of CatA hydrolysis showed good correlation within a large set of TFV phosphonoamidate prodrugs[1]. |
Synonyms | GS-7340 (hemifumarate), Tenofovir alafenamide fumarate |
Molecular Weight | 534.51 |
Formula | C21H29N6O5P·1/2C4H4O4 |
CAS No. | 1392275-56-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (93.55 mM)
You can also refer to dose conversion for different animals. More
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Tenofovir alafenamide hemifumarate 1392275-56-7 Microbiology/Virology Proteases/Proteasome HIV Protease Reverse Transcriptase Inhibitor GS 7340 Human immunodeficiency virus Tenofovir alafenamide Fumarate GS-7340 (hemifumarate) inhibit Tenofovir alafenamide fumarate GS7340 HIV Tenofovir alafenamide GS-7340 GS-7340 hemifumarate Tenofovir alafenamide Hemifumarate inhibitor