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Cat No. | Product Name | Synonyms | Targets |
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T13208 | TrkA-IN-1 | Trk receptor | |
TrkA-IN-1 is a potent and selective inhibitor of Tropomyosin-related kinase A (TrkA) (IC50: 99 nM in a cell-based assay) with analgesic activity. | |||
T40294 | ITK/TRKA-IN-1 | ||
ITK/TRKA-IN-1 is a chemical compound that functions as a dual inhibitor of IL-2-inducible T-cell kinase (ITK) and tropomyosin receptor kinase A (TRKA). With an IC50 value of 1.0 nM, it effectively inhibits the activity o... | |||
T73306 | TrkA-IN-3 | ||
TrkA-IN-3 is a potent, subselective, and allosteric inhibitor of TrkA, demonstrating significant potency with an IC50 of 22.4 nM. It exhibits over 8000-fold selectivity towards TrkA in comparison to TrkB and TrkC, making... | |||
T73307 | TrkA-IN-4 | ||
TrkA-IN-4, a potent, orally active and allosteric TrkA inhibitor, is a prodrug of TrkA-IN-3 . TrkA-IN-4 exhibits potent antinociceptive effects [1] . | |||
T62801 | FLT3/TrKA-IN-1 | ||
FLT3/TrKA-IN-1 is a potent FLT3/TrKA dual kinase inhibitor, capable of acting on FLT3 (IC50: 43.8 nM), FLT3-ITD (IC50: 97.2 nM), FLT3-TKD (IC50: 92.5 nM) and TrKA (IC50: 23.6 nM). -FLT3/TrKA-IN-1 has potential for acute ... | |||
T16766 | Ro 08-2750 | ||
Ro 08-2750 is a non-peptide and reversible nerve growth factor (NGF) inhibitor which binds to NGF, and with an IC50 of ~ 1 µM. Ro 08-2750 is a selective MSI RNA-binding activity inhibitor, with an IC50 of 2.7 μM. Ro 08-2... | |||
T12731 | RIPK1-IN-7 | RIP kinase | |
RIPK1-IN-7 is a potent and selective inhibitor of RIPK1(Kd of 4 nM and an enzymatic IC50 of 11 nM),andexhibits excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model. | |||
T9123 | DS-1205 | TAM Receptor | |
DS-1205 is a potent and selective inhibitor of AXL kinase, with an IC50 of 1.3 nM. DS-1205 also inhibits MER, MET, and TRKA, with IC50s of 63, 104, and 407 nM, respectively. DS-1205 can inhibit cell migration in vitro an... | |||
T6712 | Tyrphostin AG 879 | AG 879 | Apoptosis , EGFR , Trk receptor , HER , PDGFR |
Tyrphostin AG 879 (AG 879) effectively inhibits HER2/ErbB2 (IC50: 1 μM), 100- and 500-fold higher selective to ErbB2 than EGFR and PDGFR. | |||
T0678 | Amitriptyline hydrochloride | Amitriptyline HCl,Tryptizol,Domical,Annoyltin | Trk receptor , Sigma receptor , 5-HT Receptor , Serotonin Transporter , Sodium Channel , Adrenergic Receptor , AChR , Norepinephrine , Histamine Receptor |
Amitriptyline hydrochloride (Annoyltin) is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive activities. | |||
T4349 | Sitravatinib | MG516,MGCD516 | Discoidin Domain Receptor (DDR) , VEGFR , FLT , Trk receptor , TAM Receptor , c-Kit , Ephrin Receptor |
Sitravatinib (MGCD516) (MGCD516) is an inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Met, c-Kit, PDGFRα/β, PDGFR, and Axl. | |||
T39266 | HTrkA-IN-1 | ||
hTrkA-IN-1 is a potent and orally active inhibitor of TrkA kinase with an IC 50 of 1.3 nM, compound 2.hTrkA-IN-1 can be used for the study of inflammatory disease, such as prostatitis, pelvic, et al. | |||
T63223 | HTrkA-IN-2 | ||
hTrkA-IN-2 is a selective hTrkA metamorphosis inhibitor (IC50: 3.9 nM). | |||
T7435 | Selitrectinib | LOXO-195 | Trk receptor |
Selitrectinib (LOXO-195) is a potent and selective inhibitor of the receptor tyrosine kinases(TRK)( TrkA and TrkC with IC50s of 0.6 and <2.5 nM, respectively) | |||
T14921 | CE-245677 | Tie-2 , Trk receptor | |
CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases. With a cellular IC50s of 4.7 and 1 nM. | |||
T6052 | GW 441756 | Apoptosis , Raf , Trk receptor , CDK | |
GW 441756 is a specific Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 value of 2 nM. | |||
T6097 | GNF-5837 | GNF 5837 | Trk receptor , PDGFR , c-Kit |
GNF-5837 is a specific, and orally bioavailable pan-TRK inhibitor for TrkA/TrkB (IC50: 8/12 nM). | |||
T14363 | AZ-23 | AZ 23,AZ23 | Trk receptor |
AZ-23 is an inhibitor of ATP-competitive and Trk kinase A/B/C. For TrkA, TrkB, FGFR1, Flt3, Ret, MuSk, Lck, the IC50s values are 2 nM, 8 nM, 24 nM, 52 nM, 55 nM, 84 nM, 99 nM, respectively. | |||
T5635 | CH7057288 | Trk receptor | |
CH7057288 is an effective and selective TRK inhibitor with an IC50 value of 1.1 nM, 7.8 nM and 5.1 nM for TRKA, TRKB and TRKC, respectively. | |||
T4257 | Belizatinib | TSR-011 | Trk receptor , ALK |
Belizatinib (TSR-011) is an effective, oral and dual inhibitor of ALK (IC50: 0.7 nM, wild-type recombinant ALK) and TRKA, TRKB, and TRKC. | |||
T9292 | ALE-0540 | ALE0540 | Others , Trk receptor |
ALE-0540 is a nonpeptidic heterocyclic molecule that inhibits the binding of NGF to p75 and TrkA, as well as signal transduction and biological responses mediated by TrkA receptors. | |||
T3678 | Entrectinib | RXDX-101,NMS-E628 | Trk receptor , ROS , ALK , Autophagy , ROS Kinase |
Entrectinib (RXDX-101) is an inhibitor of TrkA (IC50: 1.7 nM), TrkB (IC50: 0.1 nM), and TrkC (IC50: 0.1 nM), as well as anaplastic lymphoma kinase (ALK; IC50: 1.6 nM) and C-ros oncogene 1 (ROS1; IC50: 0.2 nM). Entrectini... | |||
T2349 | BMS-754807 | Trk receptor , c-Met/HGFR , IGF-1R | |
Dual IGF-1R/InsR Inhibitor BMS-754807 is an oral small molecule inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (InsR) tyrosine kinases with potential antineoplastic activity. | |||
T41224 | CG 428 | Trk receptor | |
CG 428 is a potent tropomyosin receptor Kinase (TRK) Degrader (uSMITETM) with a DC50 of 0.36 nM. CG 428 comprises an analog of the pan-TRK inhibitor GNF-8625 joined by a linker to the cereblon E3 ligase ligand pomalidom... | |||
T5995 | Larotrectinib | LOXO-101,ARRY-470 | Apoptosis , Trk receptor |
Larotrectinib (LOXO-101) is an orally administered inhibitor of the TRK kinase and is highly selective only for the TRK family of receptors(IC50s = 2-20 nM). | |||
T4071 | Repotrectinib | TPX-0005,TPX 0005,TPX0005 | Trk receptor , ROS , Src , ALK , ROS Kinase |
Repotrectinib (TPX-0005) is a potent ALK/ROS1/TRK inhibitor, with IC50 of 1.01 nM, 5.3 nM, 1.08 nM and 1.26 nM for WT ALK, SRC, ALK L1196M and ALK G1202R, respectively. | |||
T78968 | TRK-IN-23 | Trk receptor | |
TRK-IN-23 (compound 24b) is a potent, orally active inhibitor of TRK with IC50s of 0.5 nM for TRKA, 9 nM for TRKC, 14 nM for TRKA G595R, 4.4 nM for TRKA F589L, and 4.8 nM for TRKA G667C. It induces apoptosis in Ba/F3-TRK... | |||
T17170 | PF-06737007 | Trk receptor | |
PF-06737007 is an effective inhibitor of pan-Trk in cell-based assays (IC50s: 7.7 nM, 15 nM, and 3.9 nM for TrkA, TrkB, and TrkC, respectively). | |||
T13207 | PF-06733804 | Trk receptor | |
PF-06733804 is a potent inhibitor of pan-Trk in cell-based assays (IC50s: 8.4 nM, 6.2 nM, and 2.2 nM for TrkA, TrkB, and TrkC) with anti-hyperalgesic effect. | |||
T29020 | TSR-011-isomer | TSR011 isomer,TSR-011 isomer,Belizatinib isomer | |
TSR011-isomer, a TrKA/ALK inhibitor, is used potentially for the treatment of solid tumours and lymphoma. | |||
T62093 | Trk-IN-11 | ||
Trk-IN-11 (Compound 14h) is a potent inhibitor of TRK, with IC50 values of 1.4 nM for TrkA and 1.8 nM for TrkA G595R. Trk-IN-11 has shown research potential in cancer diseases. | |||
T15738 | Lestaurtinib | KT-5555,CEP-701 | Others |
Lestaurtinib is a multi-kinase inhibitor. It also has effective activity against the Trk family of receptor tyrosine kinases. Lestaurtinib inhibits JAK2, FLT3, and TrkA (IC50s: 0.9, 3, and less than 25 nM). | |||
T11729 | JTE-952 | Histamine Receptor | |
JTE-952 is a oral, potent active and selective Type II inhibitor of colony stimulating factor-1 receptor (CSF-1R or cFMS, type III receptor tyrosine kinase), with IC50 values of 13 nM and 261 nM for CSF1R and TrkA , resp... | |||
T17169 | Trk-IN-4 | PF-6683324 isomer | Trk receptor |
Trk-IN-4 is an effective pan-Trk inhibitor in cell-based assays (IC50s: 1.9 nM, 2.6 nM, and 1.1 nM for TrkA, TrkB, and TrkC, respectively). | |||
T73033 | TRK II-IN-1 | Trk receptor | |
TRK II-IN-1 is a potent type II inhibitor of tropomyosin receptor kinases (TRK), demonstrating inhibitory half-maximal inhibitory concentrations (IC50s) of 3.3, 6.4, 4.3, and 9.4 nM against TRKA, TRKB, TRKC, and the muta... | |||
T17000 | Tavilermide | MIM-D3 | Trk receptor |
Tavilermide is a selective and partial agonist of TrkA or a nerve growth factor mimetic. | |||
T62672 | D5261 | ||
D5261 is a potent, type III variant of tropomyosin-related kinase A (TrkA) inhibitor. | |||
T71121 | Milciclib maleate | ||
Milciclib maleate is an inhibitor of cyclin-dependent kinases (CDKs) and thropomyosin receptor kinase A (TRKA). | |||
T6936 | PF-03814735 | FAK , VEGFR , FLT , Trk receptor , Aurora Kinase | |
PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and FGFR1. Phase 1. | |||
T79706 | TRK-IN-24 | Trk receptor | |
TRK-IN-24 (compound 10g) is a selective inhibitor of Trk receptors, effectively targeting TRKA, TRKC, and mutant forms TRKA G595R, TRKA G667C, and TRKA F589L, with IC50 values of 5.21, 4.51, 6.77, 1.42, and 6.13 nM, resp... | |||
T61872 | Trk-IN-10 | ||
Trk-IN-10 (Compound 14j) is a highly effective inhibitor of TRK, with an IC50 of 0.86 nM against TrkA and 6.92 nM against TrkA G595R. As an RTK, Trk plays a crucial role as a drug target in solid tumors. Trk-IN-10 (IC50 ... | |||
T62341 | (R)-Larotrectinib | ||
(R)-Larotrectinib is a potent inhibitor of TRK and acts on TrkA (IC50: 28.5 nM). (R)-Larotrectinib can be used to study cancer, inflammation and certain infectious diseases. | |||
T61712 | Trk-IN-8 | ||
Trk-IN-8, a powerful TRK inhibitor, demonstrates excellent potency against TRKAa, TRKA(G595R), and TRKC(G623R) with IC50 values of 0.42 nM, 0.89 nM, and 1.5 nM, respectively (WO2021115401A1, compound 3) [1]. | |||
T68740 | NVP-TAC544 | ||
NVP-TAC544 is a novel focal adhesion kinase (FAK) inhibitor, potently blocking kinase activity of FAK along with Aurora A, activated Cdc42-associated kinase 1 (ACK1), Met, insulin receptor (IR), TrkA, and IGF-1R. | |||
T62095 | TRK-IN-19 | ||
TRK-IN-19 (Compound I-10 ) is a potent inhibitor of TRK with IC50 values of 1.1 nM for TRKA and 5.3 nM for TRKAG595R. TRK-IN-19 has shown potential research value in cancer disease. | |||
T62447 | Paltimatrectinib | PBI-200,PPI-5278 | Trk receptor , Tyrosine Kinases |
Paltimatrectinib (PBI-200) is a potent tyrosine kinase inhibitor with anticancer activity that inhibits myosin-related kinase A (TrkA).Paltimatrectinib is used in the study of bladder, breast and colorectal cancers. | |||
T22318 | Taletrectinib | DS-6051b,AB-106 | Trk receptor , ROS , ROS Kinase |
Taletrectinib (AB-106) is a new-generation selective inhibitor of ROS1/NTRK including ROS1,NTRK1,NTRK2 and NTRK3 with IC50 of 0.207 nM,0.622 nM,2.28 nM and 0.980 nM, respectively. | |||
T61551 | Trk-IN-20 | ||
Trk-IN-20 is a 3-vinylindazole derivative compound that effectively inhibits the functions of Trk kinases. It accomplishes this by suppressing the phosphorylation of TrkA, TrkB, and TrkC, with IC50 values of 1.6 nM, 2.9 ... | |||
T39896 | ALK-IN-9 | ||
ALK-IN-9 (compound 40) is a highly effective ALK inhibitor. It demonstrates remarkable inhibitory activity against cell proliferation, with IC50 values of <0.2 nM for Ba/F3-EML4-ALK, KM 12 (TPM3-TRKA), and KG-l cell (OP2... | |||
T76372 | TRAF6 peptide | ||
TRAF6 peptide, a specific TRAF6-p62 inhibitor, effectively inhibits NGF-dependent TrkA ubiquitination, showcasing strong research potential for neurological conditions including Alzheimer's disease (AD), Parkinson's, ALS... |
Cat No. | Product Name | Species | Expression System |
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TMPY-01084 | TrkA Protein, Human, Recombinant (His) | Human | HEK293 Cells |
TrkA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39.5 kDa and the accession number is P04629-1. | |||
TMPK-00774 | TrkA Protein, Human, Recombinant (aa 33-417, His) | Human | HEK293 Cells |
TrkA, a tyrosine kinase receptor, is an essential component of the nerve growth factor (NGF) response pathway. The binding of NGF to the receptor induces receptor autophosphorylation and activation of intracellular signa... | |||
TMPY-01083 | TrkA Protein, Human, Recombinant (His & hFc) | Human | HEK293 Cells |
TrkA Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 66 kDa and the accession number is P04629-1. | |||
TMPY-03470 | TrkA Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
TrkA Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 69.2 kDa and the accession number is Q3UFB7. | |||
TMPY-03536 | TrkA Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
TrkA Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.7 kDa and the accession number is Q3UFB7. | |||
TMPY-01759 | TrkA Protein, Human, Recombinant (aa 285-413, His) | Human | E. coli |
TrkA Protein, Human, Recombinant (aa 285-413, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 15.1 kDa and the accession number is P04629-1. | |||
TMPY-01760 | TrkA Protein, Human, Recombinant (aa 194-413, His) | Human | HEK293 Cells |
TrkA Protein, Human, Recombinant (aa 194-413, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26 kDa and the accession number is P04629-1. | |||
TMPY-04663 | TrkA Protein, Rabbit, Recombinant (His) | Rabbit | HEK293 Cells |
TrkA Protein, Rabbit, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.4 kDa and the accession number is XP_008262512.1. | |||
TMPY-03712 | TrkA Protein, Canine, Recombinant (His) | Canine | HEK293 Cells |
TrkA Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16.2 kDa and the accession number is XP_851619.3. | |||
TMPY-06967 | TrkA Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
TrkA Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.95 kDa and the accession number is XP_005541454.3. | |||
TMPY-03560 | TrkA Protein, Rat, Recombinant (hFc) | Rat | HEK293 Cells |
TrkA Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 69.2 kDa and the accession number is P35739. | |||
TMPY-04285 | TrkA Protein, Rat, Recombinant (His) | Rat | HEK293 Cells |
TrkA Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.7 kDa and the accession number is A6J617. | |||
TMPY-03711 | TrkA Protein, Canine, Recombinant (hFc) | Canine | HEK293 Cells |
TrkA Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42.3 kDa and the accession number is XP_851619.3. |