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Repotrectinib

Repotrectinib
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Purity:100%
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Repotrectinib

Catalog No. T4071Cas No. 1802220-02-5
Repotrectinib (TPX-0005) is a potent ALK/ROS1/TRK inhibitor, with IC50 of 1.01 nM, 5.3 nM, 1.08 nM and 1.26 nM for WT ALK, SRC, ALK L1196M and ALK G1202R, respectively.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$45In Stock
2 mg$64In Stock
5 mg$97In Stock
10 mg$172In Stock
25 mg$312In Stock
50 mg$498In Stock
100 mg$725In Stock
1 mL x 10 mM (in DMSO)$102In Stock
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Product Introduction

Bioactivity
Description
Repotrectinib (TPX-0005) is a potent ALK/ROS1/TRK inhibitor, with IC50 of 1.01 nM, 5.3 nM, 1.08 nM and 1.26 nM for WT ALK, SRC, ALK L1196M and ALK G1202R, respectively.
AliasTPX-0005, TPX 0005, TPX0005
Chemical Properties
Molecular Weight355.37
FormulaC18H18FN5O2
Cas No.1802220-02-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 60 mg/mL (168.84 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.8140 mL14.0698 mL28.1397 mL140.6984 mL
5 mM0.5628 mL2.8140 mL5.6279 mL28.1397 mL
10 mM0.2814 mL1.4070 mL2.8140 mL14.0698 mL
20 mM0.1407 mL0.7035 mL1.4070 mL7.0349 mL
50 mM0.0563 mL0.2814 mL0.5628 mL2.8140 mL
100 mM0.0281 mL0.1407 mL0.2814 mL1.4070 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
1 Enter information below:
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