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Belizatinib

Catalog No. T4257   CAS 1357920-84-3
Synonyms: TSR-011

Belizatinib (TSR-011) is an effective, oral and dual inhibitor of ALK (IC50: 0.7 nM, wild-type recombinant ALK) and TRKA, TRKB, and TRKC.

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Belizatinib Chemical Structure
Belizatinib, CAS 1357920-84-3
Pack Size Availability Price/USD Quantity
1 mg In stock $ 36.00
2 mg In stock $ 52.00
5 mg In stock $ 89.00
10 mg In stock $ 143.00
25 mg In stock $ 288.00
50 mg In stock $ 397.00
100 mg In stock $ 556.00
1 mL * 10 mM (in DMSO) In stock $ 113.00
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Purity: 99.48%
Purity: 99.33%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Belizatinib (TSR-011) is an effective, oral and dual inhibitor of ALK (IC50: 0.7 nM, wild-type recombinant ALK) and TRKA, TRKB, and TRKC.
Targets&IC50 ALK:0.7 nM
In vitro In the Clinicalal trials, Belizatinib has antitumor activity.
In vivo In mouse models, Belizatinib can continuously and effectively inhibit ALK-dependent tumor growth.
Synonyms TSR-011
Molecular Weight 577.73
Formula C33H44FN5O3
CAS No. 1357920-84-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 300 mg/mL

TargetMolReferences and Literature

1. Sullivan I, et al. ALK inhibitors in non-small cell lung cancer: the latest evidence and developments. Ther Adv Med Oncol. 2016 Jan;8(1):32-47

TargetMolCitations

1. Jin X, Liu D, Zhou X, et al.Entrectinib inhibits NLRP3 inflammasome and inflammatory diseases by directly targeting NEK7.Cell Reports Medicine.2023, 4(12).

Related compound libraries

This product is contained In the following compound libraries:
Tyrosine Kinase Inhibitor Library Anti-Cancer Active Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Inhibitor Library Fluorochemical Library Hematonosis Compound Library Anti-Lung Cancer Compound Library Bioactive Compound Library Orally Active Compound Library

Related Products

Related compounds with same targets
PF-06273340 LM22A-4 TRK-IN-24 Larotrectinib sulfate Selitrectinib TRK II-IN-1 URMC-099 TrkA-IN-1

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Belizatinib 1357920-84-3 Angiogenesis Tyrosine Kinase/Adaptors Trk receptor ALK Trk Receptor CD246 ALK tyrosine kinase receptor TSR011 Tropomyosin related kinase receptor TSR 011 inhibit Cluster of differentiation 246 TSR-011 Inhibitor Anaplastic lymphoma kinase Anaplastic lymphoma kinase (ALK) inhibitor

 

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