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Belizatinib

Name: Belizatinib
Brand: TargetMol
SKU: T4257
Price: 36 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4257Cas No. 1357920-84-3

Alias TSR-011

Belizatinib (TSR-011) is an effective, oral and dual inhibitor of ALK (IC50: 0.7 nM, wild-type recombinant ALK) and TRKA, TRKB, and TRKC.

Belizatinib

🥰Excellent

Purity: 99.44%

Catalog No. T4257Alias TSR-011Cas No. 1357920-84-3

Belizatinib (TSR-011) is an effective, oral and dual inhibitor of ALK (IC50: 0.7 nM, wild-type recombinant ALK) and TRKA, TRKB, and TRKC.

Pack Size	Price	Availability
1 mg	$36	In Stock
2 mg	$52	In Stock
5 mg	$89	In Stock
10 mg	$143	In Stock
25 mg	$288	In Stock
50 mg	$397	In Stock
100 mg	$556	In Stock
1 mL x 10 mM (in DMSO)	$113	In Stock

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Batch Information

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Purity:99.44%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Belizatinib (TSR-011) is an effective, oral and dual inhibitor of ALK (IC50: 0.7 nM, wild-type recombinant ALK) and TRKA, TRKB, and TRKC.
Targets&IC50	ALK:0.7 nM
In vitro	In the Clinicalal trials, Belizatinib has antitumor activity.
In vivo	In mouse models, Belizatinib can continuously and effectively inhibit ALK-dependent tumor growth.
Synonyms	TSR-011

Chemical Properties

Molecular Weight	577.73
Formula	C₃₃H₄₄FN₅O₃
Cas No.	1357920-84-3
Smiles	CC(C)NC(=O)[C@H]1CC[C@H](CC1)n1c(NC(=O)c2ccc(F)cc2)nc2ccc(CN3CCC(CC3)C(C)(C)O)cc12
Relative Density.	1.27 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (103.85 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7309 mL	8.6546 mL	17.3091 mL	86.5456 mL
5 mM	0.3462 mL	1.7309 mL	3.4618 mL	17.3091 mL
10 mM	0.1731 mL	0.8655 mL	1.7309 mL	8.6546 mL
20 mM	0.0865 mL	0.4327 mL	0.8655 mL	4.3273 mL
50 mM	0.0346 mL	0.1731 mL	0.3462 mL	1.7309 mL
100 mM	0.0173 mL	0.0865 mL	0.1731 mL	0.8655 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc