Home Tools

Belizatinib

Catalog No. T4257 CAS 1357920-84-3

Synonyms: TSR-011

Belizatinib is an effective, oral and dual inhibitor of ALK (IC50: 0.7 nM, wild-type recombinant ALK) and TRKA, TRKB, and TRKC.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Belizatinib, CAS 1357920-84-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 36.00
2 mg	In stock	$ 52.00
5 mg	In stock	$ 89.00
10 mg	In stock	$ 143.00
25 mg	In stock	$ 288.00
50 mg	In stock	$ 397.00
100 mg	In stock	$ 556.00
1 mL * 10 mM (in DMSO)	In stock	$ 113.00

Bulk Inquiry

Select Batch

Purity: 99.48%

Purity: 99.33%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Belizatinib is an effective, oral and dual inhibitor of ALK (IC50: 0.7 nM, wild-type recombinant ALK) and TRKA, TRKB, and TRKC.
Targets&IC50	ALK:0.7 nM
In vitro	In the Clinicalal trials, Belizatinib has antitumor activity.
In vivo	In mouse models, Belizatinib can continuously and effectively inhibit ALK-dependent tumor growth.

Synonyms	TSR-011
Molecular Weight	577.75
Formula	C33H44FN5O3
CAS No.	1357920-84-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: 300 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Sullivan I, et al. ALK inhibitors in non-small cell lung cancer: the latest evidence and developments. Ther Adv Med Oncol. 2016 Jan;8(1):32-47

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Anti-Cancer Compound Library Inhibitor Library Angiogenesis related Compound Library Tyrosine Kinase Inhibitor Library Kinase Inhibitor Library Anti-Lung Cancer Compound Library Hematonosis Compound Library Target-Focused Phenotypic Screening Library Anti-Cancer Clinical Compound Library

Related Products

Related compounds with same targets

ALK2-IN-2 TGFBR1-IN-1 OD36 hydrochloride Vactosertib Hydrochloride ALK-IN-5 MS4077 A 83-01 sodium salt (-)-Cevimeline hydrochloride hemihydrate

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

Step One: Enter information below

Dosage

mg/kg

Average weight of animals

Dosing volume per animal

Number of animals

Step Two: Enter the in vivo formulation

% DMSO+

% +

% Tween 80+

% ddH₂O

%DMSO+

Calculate Reset

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Calculator

Molarity Calculator

Dilution Calculator

Reconstitution Calculation

Molecular Weight Calculator

Mass

Concentration

Volume

Molecular Weight

Molarity Calculator allows you to calculate the

Mass of a compound required to prepare a solution of known volume and concentration
Volume of solution required to dissolve a compound of known mass to a desired concentration
Concentration of a solution resulting from a known mass of compound in a specific volume

See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

Concentration (Start)

Volume (Start)

Concentration (End)

Volume (End)

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Molecule Formula

Molecular Weight g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Belizatinib 1357920-84-3 Angiogenesis Tyrosine Kinase/Adaptors ALK Trk receptor TSR011 Trk Receptor CD246 ALK tyrosine kinase receptor Tropomyosin related kinase receptor TSR 011 inhibit Cluster of differentiation 246 Inhibitor Anaplastic lymphoma kinase TSR-011 Anaplastic lymphoma kinase (ALK) inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.