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DS-1205

DS-1205
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Purity:99.28%
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DS-1205

Catalog No. T9123Cas No. 1855860-24-0
DS-1205 is a potent and selective inhibitor of AXL kinase, with an IC50 of 1.3 nM. DS-1205 also inhibits MER, MET, and TRKA, with IC50s of 63, 104, and 407 nM, respectively. DS-1205 can inhibit cell migration in vitro and tumor growth in vivo[1].
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Pack SizePriceAvailabilityQuantity
1 mg$108In Stock
5 mg$272In Stock
10 mg$397In Stock
25 mg$738In Stock
50 mg$987In Stock
1 mL x 10 mM (in DMSO)$297In Stock
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Product Introduction

Bioactivity
Description
DS-1205 is a potent and selective inhibitor of AXL kinase, with an IC50 of 1.3 nM. DS-1205 also inhibits MER, MET, and TRKA, with IC50s of 63, 104, and 407 nM, respectively. DS-1205 can inhibit cell migration in vitro and tumor growth in vivo[1].
In vitro
DS-1205 (0.3-33 μM; 2-24 h) inhibits hGAS6-induced migration in NIH3T3-AXL cells (EC50=2.7 nM)[1]. DS-1205 (1-10000 μM; 2-24 h) significantly inhibits the phosphorylation of AXL in NIH3T3-AXL cells. DS-1205 decreases NIH3T3 cell proliferation but not obviously inhibits growth (GI50>10,000 nM)[1].
In vivo
DS-1205 (3.1-50 mg/kg; p.o. bid for 5 d) exhibits pAXL inhibition mediated antitumor effects in mice[1].
Chemical Properties
Molecular Weight735.8
FormulaC41H42FN5O7
Cas No.1855860-24-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 45 mg/mL (61.16 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.3591 mL6.7953 mL13.5906 mL67.9532 mL
5 mM0.2718 mL1.3591 mL2.7181 mL13.5906 mL
10 mM0.1359 mL0.6795 mL1.3591 mL6.7953 mL
20 mM0.0680 mL0.3398 mL0.6795 mL3.3977 mL
50 mM0.0272 mL0.1359 mL0.2718 mL1.3591 mL

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