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Angiogenesis HER Tyrphostin AG 879

Tyrphostin AG 879

Catalog No. T6712   CAS 148741-30-4
Synonyms: AG 879, AG 879

Tyrphostin AG 879 effectively inhibits HER2/ErbB2 (IC50: 1 μM), 100- and 500-fold higher selective to ErbB2 than EGFR and PDGFR.

Tyrphostin AG 879, CAS 148741-30-4
Pack Size Availability Price/USD Quantity
5 mg In stock 50.00
10 mg In stock 77.00
25 mg In stock 176.00
50 mg In stock 293.00
100 mg In stock 500.00
1 mL * 10 mM (in DMSO) In stock 54.00
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Purity 98.00%
Biological Description
Chemical Properties
Storage & Solubility Information
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Description Tyrphostin AG 879 effectively inhibits HER2/ErbB2 (IC50: 1 μM), 100- and 500-fold higher selective to ErbB2 than EGFR and PDGFR.
Targets&IC50 EGFR : ic50 >500μM ,   HER2-Neu : ic50 1.0μM ,   PDGFR : ic50 >100μM ,   Trk : ic50 10μM
In vivo AG879(2 mg) induces a decrease in cancer growth in athymic NOD/SCID mice grafted with HTB-114 or HL-60. [4] AG 879(20 mg/kg) treatment keeps 50% of mice absolutely free of RAS-induced sarcomas, and dramatically reduces the size of the growing sarcomas in the nude mice carrying v-Ha-RAS transformed NIH 3T3 cells. [5]
Cell Research
Cells are grown in 96-well plates containing 100 μL medium per well. Ten microliters of MTT solution (5 mg/ml in PBS) is added to each well and incubation continued for 4 h at 37 °C. Subsequently, 100 μL 10% SDS in 0.01 M HCl is added. After incubation at 37°C overnight, absorption is measured at 550 nm in an ELISA reader using a reference filter of 690 nm.(Only for Reference)
Cell lines: MCF-7 cells
Animal Research
Animal Model: nude mice carrying v-Ha-RAS transformed NIH 3T3 cells
Synonyms AG 879 , AG 879
Purity 98.00%
Molecular Weight 316.46
Formula C18H24N2OS
CAS No. 148741-30-4

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 31.7 mg/mL (100 mM)

Ethanol: 7.9 mg/mL (25 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Solution 1

1% DMSO/30% polyethylene glycol/1% Tween 80: 30 mg/mL

Citations

References and Literature
6. Zhou Y et al. Blockade of EGFR and ErbB2 by the novel dual EGFR and ErbB2 tyrosine kinase inhibitor GW572016 sensitizes human colon carcinoma GEO cells to apoptosis. Cancer Res. 2006 Jan 1;66(1):404-11.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Inhibitor Library Anti-cancer Compound Library Tyrosine kinase inhibitor library Kinase Inhibitor Library Angiogenesis related Compound Library JAK STAT Compound Library

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