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CE-245677

Catalog No. T14921 CAS 717899-97-3

CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases. With a cellular IC50s of 4.7 and 1 nM.

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CE-245677, CAS 717899-97-3

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Purity: 98%

Biological Description

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Description	CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases. With a cellular IC50s of 4.7 and 1 nM.
Targets&IC50	TrkB:1 nM, TrkA:1 nM, Tie-2:4.7 nM
In vitro	CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50 of 4.7 and 1 nM. Which displays >100x selectivity against a number of other angiogenic receptor tyrosine kinases, such as KDR, PDGFR, FGFR[1].
In vivo	In vivo rat, CE-245677 displays good oral absorption PK studies (F=80%)[1].

Molecular Weight	513.38
Formula	C24H22Cl2N6O3
CAS No.	717899-97-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 125 mg/mL (243.48 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Susan LaGreca, et al. Identification of selective, orally active Tie2 kinase inhibitors and discovery of CE-245,677 and PF-371,989. Cancer Research. AACR Annual Meeting-Apr 14-18, 2007.

Related compound libraries

This product is contained In the following compound libraries：

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Related Products

Related compounds with same targets

Pexmetinib Tie2 kinase inhibitor 1 GSK-1070916 EOC317 Foretinib Altiratinib CE-245677

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CE-245677 717899-97-3 蛋白酪氨酸激酶 Tie-2 Trk receptor Inhibitor CE 245677 Tropomyosin related kinase receptor Trk Receptor CE245677 inhibit inhibitor

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