Powder: -20°C for 3 years
In solvent: -80°C for 2 years
CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases. With a cellular IC50s of 4.7 and 1 nM.
Description | CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases. With a cellular IC50s of 4.7 and 1 nM. |
Targets&IC50 | TrkB:1 nM, TrkA:1 nM, Tie-2:4.7 nM |
In vitro | CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50 of 4.7 and 1 nM. Which displays >100x selectivity against a number of other angiogenic receptor tyrosine kinases, such as KDR, PDGFR, FGFR[1]. |
In vivo | In vivo rat, CE-245677 displays good oral absorption PK studies (F=80%)[1]. |
Molecular Weight | 513.38 |
Formula | C24H22Cl2N6O3 |
CAS No. | 717899-97-3 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 125 mg/mL (243.48 mM), Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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CE-245677 717899-97-3 蛋白酪氨酸激酶 Tie-2 Trk receptor Inhibitor CE 245677 Tropomyosin related kinase receptor Trk Receptor CE245677 inhibit inhibitor