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Tavilermide

Name: Tavilermide
Brand: TargetMol
SKU: T17000
Price: 199 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T17000Cas No. 263251-78-1

Alias MIM-D3, MIMD3

Tavilermide (MIM-D3) is a selective TrkA agonist, a cyclic mimetic, which can be used to study dry keratoconjunctivitis and dry eye syndrome.

Tavilermide

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Purity: 98.98%

Catalog No. T17000Alias MIM-D3, MIMD3Cas No. 263251-78-1

Tavilermide (MIM-D3) is a selective TrkA agonist, a cyclic mimetic, which can be used to study dry keratoconjunctivitis and dry eye syndrome.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$199	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.98%

Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	Tavilermide (MIM-D3) is a selective TrkA agonist, a cyclic mimetic, which can be used to study dry keratoconjunctivitis and dry eye syndrome.
In vitro	Tavilermide, a tyrosine kinase TrkA receptor agonist, is a protease-stabilized cyclic peptide mimetic that has been shown to be a partial TrkA receptor agonist for the treatment of dry eye. Tavilermide exhibits activity similar to that of nerve growth factor (NGF), but does not bind to the p75NTR receptor, and enhances the effects of suboptimal concentrations of effects of NGF. [1]
Synonyms	MIM-D3, MIMD3

Chemical Properties

Molecular Weight	580.54
Formula	C₂₄H₃₂N₆O₁₁
Cas No.	263251-78-1
Smiles	O=C1C=2C(=CC=C(N(=O)=O)C2)OCC[C@@H](C(NCC(O)=O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)N1
Relative Density.	1.341 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

NH4OH: 30 mg/mL(51.68 mM), when pH is adjusted with NH4OH. Sonication is recommmended.

H2O: 5 mg/mL (8.61 mM), Sonication is recommended.

Solution Preparation Table

H2O/NH4OH

	1mg	5mg	10mg	50mg
1 mM	1.7225 mL	8.6127 mL	17.2253 mL	86.1267 mL
5 mM	0.3445 mL	1.7225 mL	3.4451 mL	17.2253 mL

NH4OH

	1mg	5mg	10mg	50mg
10 mM	0.1723 mL	0.8613 mL	1.7225 mL	8.6127 mL
20 mM	0.0861 mL	0.4306 mL	0.8613 mL	4.3063 mL
50 mM	0.0345 mL	0.1723 mL	0.3445 mL	1.7225 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc