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Trk-IN-4

Name: Trk-IN-4
Brand: TargetMol
SKU: T17169
Rating: 4.5 (1 reviews)

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Catalog No. T17169Cas No. 1799788-94-5

Alias PF-6683324

Trk-IN-4 (PF-6683324) is a potent pan-Trk inhibitor with IC50 = 1.1~2.6 nM for TrkA/TrkB/TrkC and antinociceptive effects. It is also a selective type II PTK6 inhibitor with IC50 = 76 nM and has antitumor effects.

Trk-IN-4

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Purity: 98.13%

Catalog No. T17169Alias PF-6683324Cas No. 1799788-94-5

Product information is being updated, if you want to purchase, please click the bulk custom button.

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Purity:98.13%

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COA

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	Trk-IN-4 (PF-6683324) is a potent pan-Trk inhibitor with IC50 = 1.1~2.6 nM for TrkA/TrkB/TrkC and antinociceptive effects. It is also a selective type II PTK6 inhibitor with IC50 = 76 nM and has antitumor effects.
Targets&IC50	K+ channel (hERG):14 μM, TrkC:1.1 nM, TrkA:1.9 nM, TrkB:2.6 nM
In vitro	Trk-IN-4 is a potent pan-Trk inhibitor with cellular IC₅₀ values of 1.9 nM (TrkA), 2.6 nM (TrkB), and 1.1 nM (TrkC), showing high kinase selectivity and low hERG liability (IC₅₀ = 14 μM), with favorable lipophilic efficiency (LipE = 5.7)[1].
In vivo	Trk-IN-4 showed significant antinociceptive activity in a rat UV burn hyperalgesia model at oral doses of 0.03-3 mg/kg, with maximal effects at 3 mg/kg. Trk-IN-4 demonstrated good oral bioavailability (52%), low clearance, and peripheral restriction (Cb,u/Cp,u = 0.043), supporting its use as a pain therapeutic with minimal CNS side effects[1].
Alias	PF-6683324

Chemical Properties

Molecular Weight	521.46
Formula	C₂₄H₂₃F₄N₅O₄
Cas No.	1799788-94-5
Smiles	O(C1=C(C(N)=O)C=C(C=N1)C=2N=CN(C)C2)[C@@H]3[C@H](F)CN(C(CC4=CC=C(OC(F)(F)F)C=C4)=O)CC3
Relative Density.	1.46 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice./Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (153.42 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9177 mL	9.5885 mL	19.1769 mL	95.8846 mL
5 mM	0.3835 mL	1.9177 mL	3.8354 mL	19.1769 mL
10 mM	0.1918 mL	0.9588 mL	1.9177 mL	9.5885 mL
20 mM	0.0959 mL	0.4794 mL	0.9588 mL	4.7942 mL
50 mM	0.0384 mL	0.1918 mL	0.3835 mL	1.9177 mL
100 mM	0.0192 mL	0.0959 mL	0.1918 mL	0.9588 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc